Ajovy is primarily indicated for the preventive treatment of migraine headaches in adults. Migraines are a neurological condition characterized by recurrent moderate to severe headaches, often accompanied by other symptoms such as nausea, vomiting, and sensitivity to light and sound.

Ajovy is specifically designed to reduce the frequency and severity of migraine attacks, helping to improve the overall quality of life for individuals who experience frequent migraines. It is not intended for the treatment of acute migraine attacks but rather for long-term prevention.

The medication is suitable for adults who experience chronic migraines, defined as experiencing 15 or more headache days per month, with each headache lasting for at least 4 hours, or episodic migraines, which occur on fewer than 15 days per month.

 Ajovy can be an effective option for individuals who have not responded well to other migraine prevention medications or who experience intolerable side effects from alternative treatments.

Ajovy belongs to a class of medications known as calcitonin gene-related peptide (CGRP) antagonists. CGRP is a neuropeptide found in the trigeminal nerve system, which is believed to play a crucial role in the pathophysiology of migraines.

During a migraine attack, CGRP levels increase, leading to vasodilation (widening of blood vessels) and inflammation in the brain. This process contributes to the pain and other symptoms associated with migraines.

Ajovy works by selectively targeting and binding to CGRP, preventing it from binding to its receptors and exerting its effects. By blocking the activity of CGRP, Ajovy inhibits vasodilation and reduces inflammation in the brain, thereby helping to prevent migraine attacks from occurring or decreasing their frequency and severity.

Ajovy is generally well-tolerated, but like any medication, it may cause side effects in some individuals. It’s important to be aware of potential side effects and to promptly notify a healthcare provider if you experience any concerning symptoms.

Common side effects 

• Injection site reactions: Redness, swelling, itching, or pain at the injection site are commonly reported side effects. These reactions are usually mild to moderate in severity and typically resolve on their own within a few days.

Serious side effects

• Allergic reactions: Some individuals may experience allergic reactions to Ajovy, characterized by symptoms such as rash, itching, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. 
• Cardiovascular events: In rare cases, Ajovy may increase the risk of cardiovascular events such as chest pain, heart attack, or stroke.
• Other serious side effects: Although less common, Ajovy may also be associated with other serious side effects such as high blood pressure, depression, or suicidal thoughts or behaviors. 

Before initiating treatment with Ajovy (fremanezumab), it is important to discuss any relevant medical history, ongoing health conditions, and concurrent medications with your healthcare provider to ensure the safe and effective use of this medication. 

Individuals with a known hypersensitivity or allergy to fremanezumab or any of the components of Ajovy should not use this medication. Allergic reactions, though rare, can be severe and may require immediate medical attention.

Ajovy may increase the risk of cardiovascular events, including heart attack and stroke, particularly in individuals with pre-existing cardiovascular conditions or risk factors. It is essential to assess cardiovascular health before initiating treatment with Ajovy and to monitor for signs and symptoms of cardiovascular events during treatment.

Ajovy may lead to increases in blood pressure. Blood pressure should be monitored regularly during treatment, especially in individuals with a history of hypertension or those at risk of developing high blood pressure.

Before starting treatment with Ajovy (fremanezumab), it is crucial to inform your healthcare provider about all medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. 

Concurrent use of Ajovy with other medications that target calcitonin gene-related peptide (CGRP), such as erenumab or galcanezumab, may result in additive effects on CGRP inhibition. This could potentially increase the risk of adverse reactions or lead to excessive suppression of CGRP activity.

Drugs that suppress the immune system, such as corticosteroids or immunosuppressants, may interfere with the body’s response to Ajovy or increase the risk of infections. Close monitoring and adjustments to the dosage of Ajovy or immunosuppressive agents may be necessary when used concomitantly.

There is limited information available regarding the potential interaction between Ajovy and hormonal contraceptives, such as oral contraceptives or hormonal patches. While no significant interactions have been reported, it is advisable to monitor for any changes in contraceptive efficacy or side effects when using Ajovy concurrently with hormonal contraceptives.

The dosage guidelines for Ajovy (fremanezumab) for the preventive treatment of migraine headaches in adults involve administering the medication subcutaneously and may vary depending on the prescribed regimen. 

For monthly dosing, the recommended dosage is 225 mg, given as a subcutaneous injection into the abdomen, thigh, or upper arm. Injection sites should be rotated with each dose to minimize the risk of injection site reactions. 

This monthly dosing schedule provides ongoing protection against migraine attacks and helps maintain consistent plasma concentrations of Ajovy throughout the treatment period. Alternatively, Ajovy can be administered quarterly as a dosage of 675 mg, given as three consecutive subcutaneous injections of 225 mg each, once every three months. 

• Ajovy (fremanezumab) is available only with a valid prescription from a licensed healthcare provider.
• Patients cannot purchase Ajovy over-the-counter; it must be obtained with authorization from a healthcare professional.
• Before prescribing Ajovy, healthcare providers evaluate the patient’s medical history, migraine symptoms, and treatment goals to determine suitability.
• Once prescribed, patients can obtain Ajovy from a licensed pharmacy or healthcare provider’s office.
• Patients must adhere to the prescribed dosage instructions and administration guidelines provided by the healthcare provider.
• Ajovy is subject to regulatory oversight to ensure its safety, efficacy, and appropriate use.
• Patients should consult their healthcare provider for any questions or concerns regarding Ajovy, including its prescription, administration, or potential side effects.

1. What is Ajovy used for?
   Ajovy is a prescription medication used for the preventive treatment of migraines in adults. It helps reduce the frequency of migraine attacks.

2. How does Ajovy work?
   Ajovy works by blocking the activity of a protein called calcitonin gene-related peptide (CGRP), which is involved in migraine development. This helps prevent migraine episodes.

3. How is Ajovy administered?
   Ajovy is administered as an injection under the skin, either once a month or as three injections taken on the same day every three months.

4. What are the common side effects of Ajovy?
   The most common side effects include injection site reactions such as pain, redness, or swelling. Some people may also experience allergic reactions.

5. Can Ajovy cause allergic reactions?
   Yes, Ajovy can cause allergic reactions, which may include symptoms like itching, rash, hives, or swelling. Seek medical help if you experience these symptoms.

6. What should I do if I miss a dose of Ajovy?
   If you miss a dose, take it as soon as you remember. For monthly dosing, take the next dose one month from the date of the missed dose. For quarterly dosing, take the next dose three months after the missed dose.

7. Are there any known drug interactions with Ajovy?
   Ajovy is not known to have any significant interactions with other medications, but you should still inform your healthcare provider about all your current medications.

8. How should Ajovy be stored?
   Ajovy should be stored in a refrigerator in its original packaging to protect it from light. If removed from the refrigerator, it can be stored at room temperature for up to 7 days.

9. Is it safe to drink alcohol while taking Ajovy?
   There are no specific warnings against alcohol with Ajovy, but alcohol can trigger migraines in some people. It’s advisable to limit or avoid alcohol if it worsens your condition.

10. What should be considered before starting Ajovy?
    Discuss any allergies, medical conditions, and current medications with your doctor to ensure Ajovy is a safe option for you.

11. Can Ajovy be used during pregnancy?
    It is not known if Ajovy is safe during pregnancy. Consult your doctor if you are pregnant or plan to become pregnant while on Ajovy.

12. Is Ajovy suitable for breastfeeding mothers?
    It is unclear if Ajovy passes into breast milk, so breastfeeding mothers should consult their healthcare provider before using Ajovy.

13. How long does Ajovy take to work?
    Ajovy starts working right away, but it may take several doses to notice a reduction in migraine episodes.

14. Can I use Ajovy with other migraine medications?
    Ajovy is generally used for prevention and can be used alongside some acute treatments, but always consult your doctor before combining medications.

15. Does Ajovy affect blood pressure?
    Ajovy is not known to affect blood pressure, unlike some other migraine medications.

16. What if I overdose on Ajovy?
    If you suspect an overdose, seek medical attention immediately. Symptoms may include severe side effects or allergic reactions.

17. Is Ajovy effective for all types of migraines?
    Ajovy is primarily used for preventing episodic and chronic migraines in adults but consult your healthcare provider for advice specific to your condition.

18. How is the Ajovy dose determined?
    Your doctor will recommend a suitable dosage based on your migraine frequency and lifestyle, either monthly or quarterly.

19. What should I do if I experience severe side effects?
    Contact your healthcare provider immediately if you experience severe side effects such as difficulty breathing or swelling.

20. Can Ajovy be used in children?
    Ajovy is approved for use only in adults for migraine prevention. Its safety and efficacy in children have not been established.