| Common Brands | Apriso, Asacol HD, Delzicol, Pentasa |
|---|---|
|
Drug Class |
Aminosalicylate
|
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Apriso is a mesalamine-based drug for the treatment of ulcerative colitis. It is a long-acting formulation that is released slowly in the intestines, allowing effective treatment throughout the day. This formulation acts directly on the colon, where inflammation occurs in ulcerative colitis. The reduction of this inflammation will help in managing symptoms and inducing remission in patients with active ulcerative colitis.
Typically, it is administered to patients with mild and moderate ulcerative colitis. Additionally, it is employed as a maintenance therapy to the patients who are on remission to prevent the relapse and to have an extended remission.
Apriso should be used exactly as prescribed by your healthcare provider. Here are some general guidelines:
Take Apriso once a day: It is usually administered in the morning, with or without food. Always swallow the capsules whole. Do not crush or chew the capsules, as crushing or chewing can alter the extended-release mechanism of the medication, and may cause side effects.
Consistency is key: Try to take Apriso at the same time each day to help remember your dose.
Missing a dose If you miss a dose of Apriso, take it when you remember, but only if it is nearly time for your next scheduled dose. Do not double up on the dose for an omitted dose.
Fluid Intake Drinking plenty of fluids helps decrease your chance of getting side effects of the drug such as kidney failure.
Long-Term Use: If using Apriso for maintenance therapy, you must follow the dosing instructions of your prescriber and have appointments with your healthcare provider over time.
Apriso works by giving the mesalamine, commonly called 5-aminosalicylic acid directly into the inflamed portion of the colon. This works by targeting the inflamed process within the mucous lining of the intestines while hindering the production of prostaglandins and other inflammatory mediators that contribute to the symptoms associated with the disease.
The mechanism of action of Mesalamine is not yet clear, but it acts essentially by
Inhibition of cyclooxygenase: This enzyme is involved in the production of pro-inflammatory compounds.
Reduction of free radical formation: Free radicals can cause tissue damage, and mesalamine works by neutralizing them.
Inhibition of pro-inflammatory cytokines: These are proteins that enhance inflammation.
These acts reduce the symptoms of ulcerative colitis, such as diarrhea, bleeding, and abdominal pain. Since Apriso is a modified-release medication, it is absorbed slowly in the intestines. The medication is delivered to the colon for continuous relief throughout the day.
Like all medications, Apriso may cause side effects. The most common side effects include:
Kidney problems: Mesalamine can affect kidney function. Patients taking Apriso should have their kidney function monitored regularly.
Hepatobiliary system: Some of the side effects include liver toxicity, such as yellow skin or eyes (jaundice), dark urine, or pain in the abdominal region.
Pancreatitis: Inflammation of the pancreas and may lead to signs like nausea, vomiting, and abdominal pain at the upper right part.
Allergic reactions: The least known severe reaction with symptoms that include rashes, breathing difficulties, or swelling in the face and neck area.
If any of the more serious side effects occur, seek medical help right away.
Before taking Apriso, there are some warnings and precautions to consider:
Kidney Function: Apriso may reduce kidney function and, therefore, should be used with caution in a patient with a history of kidney disease. Kidney function tests should be carried out on a regular basis while a patient is receiving Apriso.
Liver Function: Patients with liver disease should use Apriso with caution, as mesalamine can affect liver function.
Pregnancy and Breastfeeding: Apriso should be used during pregnancy only if clearly needed. It is not known whether mesalamine passes into breast milk, so it should be used cautiously in breastfeeding mothers.
Gastrointestinal Disorders: Patients with a history of gastrointestinal disorders, including bowel obstruction, should be apprised of their physician about the use of Apriso since the drug impacts bowel motility.
Apriso may interact with some medications, which may change the drug’s effectiveness or increase the chance of side effects. Some of these include:
Azathioprine or mercaptopurine: These are some of the drugs used in autoimmune diseases. Taking these drugs with Apriso may increase the risk of side effects.
Other drugs for gastrointestinal: Drugs such as antacids, H2 blockers, or proton pump inhibitors (PPIs) can change the absorption of Apriso. The effectiveness of Apriso may be reduced.
NSAIDs: Apriso and NSAIDs like ibuprofen may increase the risk of kidney problems because both drugs affect kidney function.
Patients should always report any other medication they are taking to their healthcare provider so as not to cause potential drug interactions.
Apriso usual dosage in adults is 1.5 grams per day. Doses can be increased for the patient as symptoms develop; however, the highest daily dose for patients recommended is 4.5 grams. In a maintenance therapy regime, the recommended dosage for this drug is usually 1.5 grams per day. The actual dosages are set according to a physician based on patient’s needs.
Apriso is a prescription medication and must be prescribed by a healthcare provider. It is important to follow your healthcare provider’s instructions carefully regarding dosage, timing, and any necessary monitoring tests. Regular follow-up appointments are essential to track the progress of treatment and adjust the dosage if needed.
Answer: Apriso is a manufacturing operations management software platform that helps organizations improve their production processes, enhance visibility across operations, and achieve compliance, enabling real-time decision-making.
Answer: Apriso is used by manufacturers across various industries, including automotive, aerospace, consumer goods, electronics, and pharmaceuticals, looking to optimize their operations and supply chain.
Answer: Apriso offers functionalities such as production monitoring, quality management, inventory control, compliance management, and analytics. It integrates data from multiple sources to provide a comprehensive view of manufacturing operations.
Answer: Apriso improves operational efficiency by providing real-time data visibility, streamlining communication between departments, automating processes, and offering analytics to identify areas for improvement.
Answer: Yes, Apriso can integrate with various Enterprise Resource Planning (ERP) systems such as SAP, Oracle, and Microsoft Dynamics to enhance data sharing and process synchronization across the organization.
Answer: Industries such as automotive, aerospace, food and beverage, pharmaceuticals, and electronics benefit significantly from using Apriso due to its tailored solutions for complex manufacturing environments.
Answer: Apriso can be deployed both as a cloud-based solution and on-premise, allowing companies to choose the deployment method that best fits their IT strategy and operational needs.
Answer: The key components of the Apriso suite include Manufacturing Execution System (MES), Quality Management System (QMS), and Supply Chain Management functionalities, all designed for integrated manufacturing operations.
Answer: Apriso enhances quality management by providing tools for tracking quality metrics, conducting real-time inspections, managing non-conformances, and ensuring compliance with industry standards.
Answer: Yes, Apriso supports mobile operations, allowing users to access critical information, monitor production processes, and perform quality checks through mobile devices.
Answer: Apriso provides real-time analytics, dashboards, and reporting tools that help organizations analyze production performance, quality metrics, and supply chain efficiency to make informed decisions.
Answer: Apriso helps with regulatory compliance by providing traceability, documentation, and reporting capabilities required to meet industry standards and regulations such as ISO and FDA.
Answer: Yes, Apriso can be customized to fit specific business needs through configurable workflows, user interfaces, and reporting tools, allowing organizations to adapt the software to their unique processes.
Answer: The implementation process for Apriso typically involves assessment, design, configuration, testing, training, and deployment, which can vary in duration based on the complexity of the organization’s requirements.
Answer: Apriso supports continuous improvement initiatives by providing data insights, enabling root cause analysis, and facilitating lean manufacturing practices through its integrated tools and reporting capabilities.
Answer: Apriso offers various support options, including online resources, training sessions, and customer support services to assist users in effectively utilizing the software and addressing any issues.
Answer: Yes, while Apriso is often utilized by larger enterprises, it is also suitable for small to mid-sized manufacturing businesses that seek to improve their operational processes and gain better visibility.
Answer: Apriso facilitates collaboration by providing a centralized platform for data sharing, communication tools, and real-time updates on production status, enabling teams to work together more effectively.
Answer: Yes, Apriso can help reduce manufacturing costs by optimizing processes, minimizing waste, improving quality, and enhancing overall operational efficiency, leading to lower production costs.
Answer: Apriso addresses trends such as Industry 4.0, digital transformation, automation, and increased demand for real-time data analysis, helping manufacturers stay competitive in a rapidly evolving market.
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