| Common Brands | Apriso, Asacol HD, Delzicol, Pentasa |
|---|---|
|
Drug Class |
Aminosalicylate |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Asacol HD is a brand name of the high dose formulation of mesalamine (5-aminosalicylic acid or 5-ASA). Mesalamine is an anti-inflammatory drug primarily indicated for the treatment of ulcerative colitis which is a chronic condition classified under inflammatory bowel diseases (IBD).
Asacol HD has been formulated with a purpose of releasing mesalamine in the colon where it eliminates inflammatory process as well as alleviates the painful symptoms from IBD such as abdominal pain, diarrhea, and bleeding.
Asacol HD is usually given to patients who are diagnosed with moderate to severe ulcerative colitis or those who are on treatment for their disease without any doubts about current relapse.
Asacol HD is an oral medication in the form of tablets. It is usually indicated for use as one 800 mg tablet twice daily – in the morning and evening. However, the prescribed dose may be altered according to the clinical conditions and the doctor’s directives.
– Take with a full glass of water.
– Do not crush, chew, or break the tablets: Doing so can alter the delayed-release factor which could cause undesirable effects.
– Take with or without food: Asacol HD may be taken with or without food; however, for better results, it is recommended that it be taken at the same time with respect to meals, for instance, always with food or always without food.
The mechanism of action of Asacol HD is based on a targeted approach towards localized therapy as it is capable of delivering mesalamine to the distal region of the colon where ulcerative colitis is the most active.
Asacol HD sustains mesalamine in a special delayed release form capable of withstanding the stomach and small intestines without absorption for the drug to get to the colon fully.
In colon, the mesalamine is then released to the site of action and bring about therapeutic effect such anti-inflammatories to the affected area.
This serves to:
As with any medication, Asacol HD may also lead to some unwanted effects. While them is not experienced by every patient, common side effect include:
Common Side Effects:
Prior to the commencement of Asacol HD therapy, there are various essential and necessary warnings and considerations that the clinicians are required to follow.
Anti-inflammatory use: Using Asacol HD with other anti-inflammatory agents such as NSAIDs may increase the risk of GI irritation or bleeding. This necessitates increased vigilance for GI symptoms when the two classes of drugs are used together.
Immunosuppressants: Should Asacol HD be used together with immunosuppressants like azathioprine or mercaptopurine, which are typically given for IBD, it is most likely that bone marrow suppression will occur, decreasing the white blood cell (WBC) count and thus increasing the chances of infections. Blood tests must be done at regular intervals for monitoring the possible side effects.
Antacids: Antacids, PPIs, and other drugs reducing acid levels in the stomach may reduce Asacol HD’s effectiveness, as absorption is altered in a less acidic environment. Avoid taking these medications at the same time as Asacol HD.
Asacol HD is generally initiated at 800 mg (one tablet) taken in the morning and again in the evening corresponding to 1600 mg total daily dose. The dosage may fluctuate correlating with the state of the patient, and the physician may modify the treatment in accordance with tolerability and response to therapy.
Asacol HD is a prescription medicine which can be given only under the strict supervision of a medical officer. Your doctor will also review your individual circumstances, consider the extent of your ulcerative colitis and decide whether Asacol HD is suitable for you.
Asacol HD is a prescription medication used primarily to treat ulcerative colitis and may help maintain remission in patients with this condition.
Asacol HD works by delivering the active ingredient mesalamine directly to the inflamed areas of the colon, helping to reduce inflammation and symptoms associated with ulcerative colitis.
Common side effects may include abdominal pain, gas, diarrhea, headache, and nausea. More serious side effects can occur but are less common.
Patients with a known allergy to mesalamine or any of the ingredients in Asacol HD should avoid this medication. It is also not recommended for those with severe liver or kidney problems.
Asacol HD is usually taken orally in the form of a delayed-release tablet. It’s important to follow your healthcare provider’s instructions regarding dosage and timing.
Yes, you can take Asacol HD with or without food. However, it’s best to maintain consistency in how you take it.
Patients may start to notice improvements in symptoms within a few days to weeks, but full therapeutic effects may take longer. Individual responses vary.
Asacol HD is generally considered safe for long-term use under a healthcare provider’s supervision. Regular monitoring may be recommended to check for potential side effects.
Pregnant women should consult their healthcare provider before taking Asacol HD, as the potential risks and benefits must be carefully weighed.
If you miss a dose, take it as soon as you remember. However, if it’s near the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Asacol HD can interact with other medications, including other anti-inflammatory drugs or blood thinners. Always inform your healthcare provider about all medications and supplements you are taking.
No, Asacol HD tablets should be swallowed whole to ensure the medication is released properly in the digestive system.
Store Asacol HD at room temperature, away from moisture and heat. Keep out of reach of children.
Symptoms may include rash, itching, difficulty breathing, or swelling of the face, lips, or throat. Seek immediate medical attention if such symptoms occur.
It’s best to consult with your healthcare provider about alcohol consumption while taking Asacol HD, as it may exacerbate some side effects.
If you experience severe side effects such as chest pain, difficulty breathing, or persistent vomiting, seek medical attention immediately.
Asacol HD is typically prescribed for adults and adolescents aged 12 and older. It’s important to consult a pediatrician for children under 12.
Yes, regular follow-up appointments with your healthcare provider are recommended to monitor your condition and any potential side effects.
You should not stop taking Asacol HD without consulting your healthcare provider, as this can lead to a flare-up of symptoms.
For more information, consult your healthcare provider, or visit the official website of the medication’s manufacturer or trusted medical resources.
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