The prescribed dose will vary with the intensity of your condition and other medical reasons. Its best medical use is achieved by adhering strictly to the guidance of a health care provider.

• Dosage: Unless otherwise indicated, the starting dosage is one tablet a day e,g, 16 mg/12.5 mg of candesartan 16mg and hydrochlorothiazide 12,5 mg. For reasons related to safety and efficacy, the doctor may increase the daily dosage up to a maximum of 32 mg/25 mg based on the effectiveness of the treatment.
• Missed dose: In case you forget to take your dose, you may take it once you remember however when it is almost time for your next dose do not take the previous one. Do not take a missed dose if the next scheduled dose is almost due, do not take two doses to make up for a missed dose.

The antihypertensive effect of Atacand HCT consists of a synergy of two actions.

• Candesartan reverses the action of angiotensin II in blood vessels, leading to vasodilation. Angiotensin II has the effect of constricting blood vessels which increases the workload of the heart hence increases blood pressure. Hence,a decrease in the effect of angiotensin II results in normalisation of blood pressure and improved perfusion.
• Hydrochlorothiazide induces hypotension by causing sodium (salt) and water loss through urine. As sodium is lost, the amount of fluid in the blood vessels is also reduced and consequently, the pressure within the blood vessels drops.

Hence, these actions help ensure that the blood pressures remain within the normal limits and protect against the development of complications like stroke, heart failure, and renal impairment.

Atacand HCT, as with any other drug, is capable of having side effects, but may not be experienced by all. Some possible side effects include the following:

• Dizziness or light-headedness, particularly upon sudden changes of position
• Pain in the head
• Lethargy or tiredness
• Feeling nauseated or having an upset abdomen
• Edema, mainly in the lower limbs (ankles or legs)

It’s critical to have a detailed discussion of all your past medical issues with your physician before using Atacand HCT. Some diseases may predispose to adverse reactions or affect how well the drug works. You are encouraged to tell your doctor if any of the following applies to you:

• A history of renal impairment or liver disease
• Having been diagnosed with high blood sugar levels
• Having hypotension or dehydration
• History of adverse reactions to any medication or other agents

Atacand HCT may also affect or be affected by the use of other medicines including other antihypertensives, potassium supplements, and nonsteroidal anti-inflammatory drugs, therefore it is advisable to alert the physician about the use of any other drugs.

Potassium-Sparing Diuretics and Supplements: Atacand HCT contains hydrochlorothiazide, a thiazide diuretic, which can cause low potassium levels (hypokalemia). Using it with potassium-sparing diuretics (e.g., spironolactone) or potassium supplements may increase the risk of hyperkalemia (high potassium levels), which can cause serious heart rhythm problems.

ACE Inhibitors and Angiotensin Receptor Blockers (ARBs): Taking Atacand HCT with ACE inhibitors (e.g., enalapril) or other ARBs (e.g., losartan) increases the risk of side effects like low blood pressure (hypotension), kidney problems, and elevated potassium levels. Close monitoring is essential when combining these medications.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): NSAIDs (such as ibuprofen or naproxen) can reduce the blood pressure-lowering effect of Atacand HCT and increase the risk of kidney damage, particularly when used for extended periods. Patients should be monitored for kidney function and blood pressure.

Lithium: Atacand HCT can increase lithium levels in the blood, leading to lithium toxicity. Symptoms of toxicity include nausea, tremors, and confusion. If combined, lithium levels should be closely monitored and adjustments made as necessary.

Atacand HCT is usually initiated with an effective dose of 16 mg/12.5 mg once-daily. After assessing how well the patient took the medicine, the physician may adjust the dose to a larger one. Generally the maximal dose recommended is 32 mg/25 mg taken once a day.

If the dosage is altered it should be in accordance with the physician’s instructions. Changing the dose without permission is not advisable. Doses are adjusted to the most appropriate value by the physician depending on blood pressure levels and a patient’s condition.

Atacand HCT is available only via a medical prescription. It can only be given when the patient has seen a qualified doctor and assessed for the health condition and checks whether Atacand HCT treatment is suitable. Your doctor will also review ongoing treatment and may change the treatment dose or regimen if necessary.

1. What is Atacand HCT?

   • Atacand HCT is a prescription medication that combines two active ingredients: candesartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. It is primarily used to treat hypertension.

2. How does Atacand HCT work?

   • Candesartan lowers blood pressure by blocking the action of a substance in the body that constricts blood vessels. Hydrochlorothiazide helps prevent the reabsorption of sodium and water, reducing blood volume and pressure.

3. What are the common uses for Atacand HCT?

   • Atacand HCT is used to treat high blood pressure and may be prescribed to help reduce the risk of complications from hypertension, such as stroke or heart attack.

4. What are the potential side effects of Atacand HCT?

   • Common side effects include dizziness, fatigue, headache, and mild abdominal pain. Serious side effects can include low blood pressure, kidney problems, and electrolyte imbalances.

5. How should Atacand HCT be taken?

   • Atacand HCT is usually taken once daily, with or without food. It’s important to follow your healthcare provider’s instructions regarding dosage.

6. Can I take Atacand HCT if I’m pregnant?

   • Atacand HCT is not recommended during pregnancy, especially in the second and third trimesters, as it could harm the fetus. Consult your doctor if you are pregnant or planning to become pregnant.

7. Is Atacand HCT safe for elderly patients?

   • Elderly patients may be more sensitive to the effects of Atacand HCT, particularly the risk of low blood pressure. Close monitoring by a healthcare provider is recommended.

8. Can Atacand HCT be taken with other medications?

   • Atacand HCT may interact with other medications, including diuretics, NSAIDs, and certain blood pressure medications. Always inform your doctor about all medications you are taking.

9. What should I do if I miss a dose of Atacand HCT?

   • If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your normal schedule. Do not double up.

10. Are there any dietary restrictions while taking Atacand HCT?

    • It’s advisable to maintain a balanced diet, but excessive salt intake should be limited. Discuss any specific dietary needs with your healthcare provider.

11. How long does it take for Atacand HCT to lower blood pressure?

    • Some patients may see a reduction in blood pressure within a few hours, while full effects may take several weeks of consistent use.

12. Can I stop taking Atacand HCT suddenly?

    • It’s important not to stop Atacand HCT suddenly without consulting your doctor, as this could lead to a rebound increase in blood pressure.

13. What should I do if I experience severe side effects?

    • If you experience severe side effects, such as trouble breathing, swelling of the face or throat, or persistent dizziness, seek medical attention immediately.

14. Is Atacand HCT effective for all types of hypertension?

    • Atacand HCT is effective for essential hypertension, but individual results may vary. Your healthcare provider can determine if it’s right for your specific situation.

15. How does Atacand HCT compare to other blood pressure medications?

    • Atacand HCT combines the benefits of an ARB and a thiazide diuretic, which may provide greater efficacy for some patients compared to using each medication separately.

16. Can Atacand HCT cause dehydration?

    • Due to the diuretic effect of hydrochlorothiazide, Atacand HCT can potentially lead to dehydration, particularly if fluid intake is insufficient.

17. What monitoring is required while taking Atacand HCT?

    • Regular monitoring of blood pressure, kidney function, and electrolyte levels is recommended, especially during the initial phase of treatment.

18. Is Atacand HCT prescribed for conditions other than hypertension?

    • While primarily used for hypertension, it may also be prescribed off-label for conditions like heart failure or chronic kidney disease, depending on the patient’s health situation.

19. What should I tell my doctor before starting Atacand HCT?

    • Inform your doctor about any existing medical conditions, allergies, and all medications or supplements you are currently taking.

20. Where can I find more information about Atacand HCT?

    • Detailed information can be found in the patient’s information leaflet that accompanies the medication, or by consulting your healthcare provider.