Hydroxyzine exerts its action through hiethamine receptor antagonism in the central nervous system and elsewhere. Histamine is a molecule that Crystallizes in the structure of the immune response and allergic suffering.
This is most clearly seen when the receptor is activated by histamine and the response includes itch, angioedema and other constituents of allergy. Hydroxyzine decreases the allergy response of pruritus, hives, and rhinorrhea through this mechanism by receptor blockade.
While hydroxyzine’s sedative properties are beneficial due to their pharmacological action in the central nervous system, their clinical usefulness depends on their street-legal availability.
The anticholinergic action of the drug proves useful whereby the drug inhibits the action of acetylcholine which is a neurotransmitter necessary for different activities in the body including moods and alertness. This plays a role in the alleviation of anxiety or stress. Therefore, it is possible hydroxyzine has some mechanism of actions as an antiemetic.
Atarax is useful in the management of a number of symptoms, however it has some side effects, some of which can be severe. Common side effects include:
- Drowsiness or sedation: As Atarax has sedative action, drowsiness is a typical side effect. This may hinder your ability to undertake certain activities where you need to be alert, for example driving or operating any machinery.
- Dry mouth: Like most antihistamines, hydroxyzine can induce dry mouth which can be quite unpleasant.
- Dizziness or lightheadedness, more so upon standing up quickly.
- Headaches.
- Blurred vision: Atarax has anticholinergic properties which may give you blurred vision or make focusing difficult for a short duration.
- Nausea or constipation: Some individuals may complain of stomach upset or other discomfort in the digestive system.
Drowsiness: Due to the sedative effects of Atarax, other central nervous system depressants, alcohol or sleeping pills, should be avoided without a doctor’s advice.
- Elderly patients: The elderly population may have heightened sensitivity to the sedative and anticholinergic effects of Atarax, therefore increasing the occurrence of fall, confusion or urinary retention.
• Operating machinery: Due to the sedative effect associated with this medication, drivig, operating heavy machineries, engaging in activities that require full concentration should be avoided until you know how Atarax affects you.
- Central Nervous System Depressants: Atarax can enhance the sedative effects of other CNS depressants, such as alcohol, benzodiazepines (e.g., diazepam, lorazepam), opioids (e.g., morphine, oxycodone), and barbiturates. This may lead to excessive drowsiness, respiratory depression, and impaired motor skills. Caution is advised when combining these medications.
- Other Antihistamines: Taking Atarax with other antihistamines, either prescription or over-the-counter (e.g., diphenhydramine), may increase the risk of side effects like dry mouth, blurred vision, urinary retention, and constipation due to additive anticholinergic effects. It’s recommended to avoid combining multiple antihistamines.
- Monoamine Oxidase Inhibitors (MAOIs): Atarax can interact with MAOIs (e.g., phenelzine, tranylcypromine), leading to an increased risk of serious side effects, including severe hypertension and serotonin syndrome. It is advised to avoid using Atarax within 14 days of discontinuing an MAOI.
- Anticholinergic Medications: Combining Atarax with other anticholinergic drugs (such as certain antidepressants, antipsychotics, or bladder medications) may increase the risk of side effects like dry mouth, urinary retention, blurred vision, and confusion, especially in older adults.
Always consult with a healthcare provider before taking Atarax with other medications to avoid potential interactions.
Atarax dosage is conditional upon age, response to treatment or condition being treated.
- For anxiety or tension: 50-100 mg per day in smaller doses.
- For sleeplessness: 25-100mg to be taken before sleep.
- For allergic or itchy reaction: 25mg not more than 4 times a day.
- For nausea or vomiting: 25mg no more than 3 times a day.
The healthcare provider will determine the best doses suitable for you at any point in time and may modify the doses in the course of time.
Atarax is controlled substance and may be dispensed only with a doctor’s prescription. It means that a patient should refrain from self-medication and take the drug exclusively under the control of a doctor who will evaluate the benefits of the drug as opposed to its risks depending on the medical history and symptoms. Always stick to the recommended dosage and consult a doctor before stopping or changing the treatment without his recommendations.