| Common Brands | Auryxia |
|---|---|
|
Drug Class |
Phosphate binder |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
No Lower-cost generic available |
|
Availability |
Prescription only |
Auryxia is an iron-based, orally administered treatment drug. It is mainly prescribed to control or treat certain disorders associated with kidney disease, such as hyperphosphatemia and iron deficiency anemia in patients with CKD not requiring dialysis.
Its distribution brand is Akebia Therapeutics, with the active ingredient ferric citrate, being a compound of both iron and citrate. Auryxia is not only a phosphate binder but also an iron source that addresses two complications created by this patient with CKD.
Phosphate binder control is important because CKD patients are usually plagued by excessive phosphate levels in the blood, which they cannot get rid of since the nephrons are not functioning efficiently in filtering out excess phosphate.
Auryxia must be taken exactly as directed by a doctor. Oral doses are usually based on the requirements of the patient. Here are some basic guidelines on how it should be administered:
Dosage: Auryxia tablets should be taken with food in order to achieve maximum stomach phosphate binding. This ensures that phosphate from the food taken in is effectively bound and not absorbed into the body.
Dosing Frequency: Auryxia may be administered two to three times daily, depending on the patient’s phosphate levels and iron status.
Oral Administration: The tablets are to be taken whole with water. Do not crush or chew the tablets, as this could interfere with the normal absorption and function of the medication.
Auryxia works in the body through its exclusive composition of ferric citrate, with functions in two ways. The ferric citrate component is a type of iron taken orally to bind phosphate in the intestines. The binding of the drug on phosphate prevents its absorption into the blood system.
Binding phosphate, Auryxia reduces serum phosphate levels. This is imperative as patients with chronic kidney disease often have impaired kidneys that are unable to filter excess phosphate adequately and, therefore, hyperphosphatemia occurs.
High phosphate levels result in the calcification of blood vessels and organs leading to sequelae such as cardiovascular disease and bone diseases.
All medicines can cause side effects. However, not everyone who takes them will experience this. Common and less common side effects of Auryxia are listed below:
Common Side Effects:
Gastrointestinal Problems- Nausea, constipation, diarrhea, stomach pains, and bloating are common symptoms but can occur as the body acclimatizes to this medication.
Colored Stools: The presence of iron in Auryxia leads to dark-colored stools, which is normally harmless but can be alarming when unexpected.
Serious Side Effects:
Iron Overload: Because Auryxia drives up the levels of iron in the blood, there is a risk of iron overload if the medication is not followed as prescribed or other iron supplements are also concurrently taken.
There is a risk of iron overload. Patients with conditions such as hemochromatosis, a body disorder that causes it to absorb too much iron, should not take Auryxia unless instructed otherwise by their physician. Monitoring of serum iron levels is an important precaution to avoid iron toxicity.
Pregnancy and Breastfeeding: Auryxia has not been established to be safe in pregnant or nursing women. Patients who are pregnant or breastfeeding should always consult their healthcare provider before taking Auryxia.
Drug Interactions: Auryxia can interact with other medications, like other iron supplements, antibiotics, and phosphate binders. You need to make your doctor aware of any medication you are currently on.
Iron Supplements: Since Auryxia contains iron, taking additional iron supplements or multivitamins with iron can increase the risk of iron overload, potentially leading to toxicity.
Phosphate Binders: Auryxia may interact with other phosphate binders (like calcium acetate or sevelamer) used to control phosphorus levels in patients with chronic kidney disease. Combining these may require careful monitoring of phosphorus levels.
Antacids: Medications that reduce stomach acid, such as proton pump inhibitors (PPIs) or H2 blockers, can decrease the absorption of iron from Auryxia, reducing its effectiveness.
Antibiotics: Some antibiotics, especially those like tetracyclines or quinolones, may have reduced effectiveness when taken with Auryxia, as iron can interfere with the absorption of these medications.
The dosage of Auryxia will depend on the patient’s condition, mainly his phosphate and iron level. However, general guidelines are:
For Hyperphosphatemia: Usually, initiation begins at 2 tablets taken with each meal and may be adjusted by the healthcare provider to be based on the patient’s response and phosphate levels.
For Iron Deficiency Anemia: The dosage may vary, and adjustments will be based on the patient’s iron levels, with regular monitoring through blood tests.
Auryxia is a prescription drug, implying that it can only be prescribed by a doctor. Therefore, it is important to see a doctor to determine if this medication is appropriate for a specific condition and to get the proper prescription.
In addition to this, Auryxia should be used only under the guidance of a healthcare provider who knows the patient’s medical history and current health status
What is Auryxia?
Auryxia (ferric citrate) is a prescription medication used to control phosphorus levels in patients with chronic kidney disease (CKD) who are on dialysis and to treat iron deficiency anemia in adults with CKD.
How does Auryxia work?
Auryxia works by binding to dietary phosphorus in the gastrointestinal tract, reducing its absorption, and also helps increase iron levels in patients with anemia.
Who should take Auryxia?
Auryxia is indicated for adults with chronic kidney disease, specifically those on dialysis and suffering from elevated phosphorus levels or iron deficiency anemia.
What are the common side effects of Auryxia?
Common side effects include nausea, diarrhea, constipation, darkened stools, and bloating. It’s essential to discuss any adverse effects with your doctor.
Can Auryxia be taken with other medications?
Auryxia can interact with certain medications, so it’s important to inform your healthcare provider about all other drugs you’re taking, including over-the-counter medications.
How should Auryxia be taken?
Auryxia is typically taken three times daily with meals. It’s crucial to follow your doctor’s dosing instructions exactly.
Are there any dietary restrictions while taking Auryxia?
While on Auryxia, patients should follow dietary restrictions as advised by their healthcare provider regarding phosphorus and iron intake.
Is Auryxia safe during pregnancy?
Auryxia should only be used during pregnancy if the potential benefit justifies the risk to the fetus. Always consult a healthcare provider.
What should I do if I miss a dose of Auryxia?
If you miss a dose, take it as soon as you remember with food. If it’s close to the next scheduled dose, skip the missed dose. Never take two doses at once.
How should Auryxia be stored?
Auryxia should be stored at room temperature, away from moisture and heat, and kept out of reach of children.
Can Auryxia be used for patients not on dialysis?
Auryxia is specifically studied for patients on dialysis. Its use in non-dialysis patients should be assessed and monitored by a healthcare professional.
What monitoring is required while taking Auryxia?
Patients may require regular blood tests to monitor phosphorus and iron levels, as well as overall kidney function while on Auryxia.
Does Auryxia cause allergic reactions?
Some patients may experience allergic reactions to Auryxia, such as rash, itching, or swelling. Seek medical attention if these symptoms occur.
How does Auryxia compare to other phosphate binders?
Auryxia differs from other phosphate binders in its dual action of binding phosphorus and treating iron deficiency anemia, offering a unique benefit.
Can I take Auryxia if I have liver disease?
If you have liver disease, discuss with your provider, as Auryxia may not be suitable for you, and monitoring may be necessary.
Is Auryxia effective in treating anemia?
Yes, Auryxia can help improve iron levels and alleviate symptoms of anemia in patients with chronic kidney disease.
What should I do in case of an overdose?
In the event of an overdose, seek medical attention immediately or contact Poison Control. Symptoms of overdose might include gastrointestinal disturbances.
Are there any long-term effects of taking Auryxia?
Long-term effects are still being studied, but patients need ongoing monitoring for iron overload and gastrointestinal effects.
What is the cost of Auryxia and is it covered by insurance?
The cost of Auryxia can vary based on insurance plans, so check with your provider and pharmacy about coverage options.
Where can I find more information about Auryxia?
For more details, consult your healthcare provider, or visit the official website of the manufacturer, or review the medication guide provided with your prescription.
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