| Common Brands | Austedo, Austedo XR |
|---|---|
|
Drug Class |
VMAT2 inhibitor |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
No Lower-cost generic available |
|
Availability |
Prescription only |
Austedo is a prescription medication designed for the treatment of specific movement and neuropsychiatric disorders. Its two main targets include Tardive Dyskinesia (TD), defined as dyskinetic movements possibly involving orficeal-bucco-linguo and trunk-limb, and chorea in Huntington’s disease; these movements are resultant of progressive neurodegenerative Huntington’s disease.
Austedo contains deutetrabenazine as an active ingredient, which is the derivative of the older drug, tetrabenazine-an older medication but with a new formulation which promises higher potency with fewer side effects.
Teva Pharmaceuticals sells the drug. It acts via modulating the levels of a neurotransmitter called dopamine that forms a key mediator for controlling voluntary movements
Austedo is available as a tablet to be orally administered. Its dosage is also individualized depending on the condition to be treated. The usage of Austedo will always depend on how the patient reacts to treatment and his health status.
For TD: The recommended initial dose of Austedo is 6 mg per day; an upward titration based on response is then allowed. An increase of 6 mg is permitted in increments, up to a maximum of 48 mg daily. The frequency of dose adjustment is about weekly or bi-weekly.
Treatment of Huntington’s Disease Chorea: Treatment usually begins with a low dose; for instance, 12 mg/day, which should be gradually increased based on patient tolerance. The target dose may range between 24 mg and 48 mg per day, though only adjustments and body condition tolerance will determine that.
Austedo works through an action that selectively depletes dopamine, thus aiding in movement regulation. Dopamine is a neurotransmitter that functions in movement and coordination.
The drug’s mechanism is based on the action of its ability to prevent the activity of VMAT2, which transports dopamine into synaptic vesicles in neurons.
The amount of dopamine available for neurotransmission decreases when the VMAT2 is inhibited by deutetrabenazine.
Therefore, it becomes easier to manage hyperkinetic movement disorders such as TD and chorea since it reduces the availability of dopamine. Austedo controls the unwanted movements by reducing the release of dopamine.
Like all medications, Austedo can cause side effects. Some common and less common side effects include:
Common Side Effects:
Sleepiness or Sedation: Feeling drowsy is a common side effect of Austedo and may occur, particularly when starting treatment or increasing the dose.
Fatigue: A feeling of tiredness or low energy is common side effects of Austedo.
Depression and Mood Changes: Mood swings or depressive symptoms can be due to this medication, which must be closely monitored, especially in those patients who have a history of mood disorders.
Serious Side Effects:
Parkinsonism: It is a condition that mimics Parkinson’s disease presenting with tremors, rigidity, and slow movements.
Patients must immediately communicate any significant side effects or altered behavior to their prescribers.
Suicidal Ideation: Austedo increases the risk of suicidal thoughts or behaviors. In patients with Huntington’s disease, it may be directly related to the pharmacologic effects of the drug.
Caution in Elderly Patients: Older patients are likely to be more sensitive to the sedative and somnolent effects of Austedo.
Drug Interactions: Austedo may interact with other drugs, especially other CNS acting drugs such as sedatives, antidepressants, and anti-anxiety medications. The patient should report all concurrent medications to the healthcare provider in order to avoid adverse interactions.
Monoamine Oxidase Inhibitors (MAOIs): Taking Austedo with MAOIs (such as phenelzine or tranylcypromine) can increase the risk of serious side effects, including high blood pressure, serotonin syndrome, and other central nervous system problems.
CYP2D6 Inhibitors: Medications that inhibit the CYP2D6 enzyme (like fluoxetine or paroxetine) can increase the levels of Austedo in the body, raising the risk of side effects such as sedation or movement problems.
Antidepressants: Combining Austedo with certain antidepressants (e.g., selective serotonin reuptake inhibitors, SSRIs) can increase the risk of serotonin syndrome, a potentially life-threatening condition.
Sedatives or CNS Depressants: Using Austedo with other central nervous system depressants, such as benzodiazepines or opioids, may increase the risk of sedation, drowsiness, and difficulty breathing.
The dosage of Austedo would depend on the type of medical condition and the patient response to the medication. Here is a general guideline:
Tardive Dyskinesia (TD): Initial dose is usually 6 mg daily, with titration up to 48 mg daily
Huntington’s Disease Chorea: Typical starting dose is 12 mg daily, with titration up to 24-48 mg daily as tolerated by the patient
Always use the recommended dosing schedule, but with the constant assistance of a healthcare provider while adjusting the doses
Austedo is a prescription medication; only on prescription from a medical practitioner can one get this drug.
A person should see a doctor or specialist for proper diagnosis and determining whether the right treatment for that patient would be Austedo. Regular check-ups are required to monitor its effectiveness and adjust the dose when required.
Austedo is a medication primarily used to treat movement disorders such as tardive dyskinesia and Parkinson’s disease. It helps regulate certain chemicals in the brain.
Austedo (deutetrabenazine) works by inhibiting the vesicular monoamine transporter 2 (VMAT2), which reduces the release of dopamine and other neurotransmitters, ultimately helping to control abnormal movements.
Austedo is primarily prescribed for:
The dosage of Austedo varies depending on the individual and condition being treated. It typically starts at a low dose and may be increased gradually under a healthcare provider’s guidance.
Yes, common side effects may include:
You should consult your doctor before combining Austedo with other medications, especially those that affect the central nervous system, as interactions may enhance side effects or reduce effectiveness.
Austedo is not considered addictive, but any concerns regarding dependency should be discussed with your healthcare provider.
If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up.
The safety of Austedo during pregnancy or breastfeeding hasn’t been established. Always consult your doctor before using it in these situations.
Austedo should not be used in patients with:
Patients may start to notice improvements in their symptoms within a few weeks, but it may take longer for the full effect to be observed.
Yes, Austedo may cause mood changes, including depression. It is essential to report any significant changes in mood to your healthcare provider.
Withdrawal symptoms can occur if Austedo is discontinued abruptly. Consult your doctor for a proper tapering schedule if stopping the medication.
There are no specific dietary restrictions while taking Austedo, but it’s best to avoid alcohol, as it can enhance drowsiness and other side effects.
Yes, alternatives include medications like tetrabenazine and other therapies such as physical therapy. Speak with your healthcare provider for options tailored to your condition.
Austedo may cause drowsiness, so it’s advisable to assess how the medication affects you before driving or operating heavy machinery.
Some potential long-term effects may include changes in mood, weight gain, or the development of new movement disorders. Long-term use should be monitored by a healthcare provider.
Coverage can vary by provider and plan. Check with your insurance company to understand your benefits regarding Austedo coverage.
If you experience serious side effects like seizures, severe dizziness, or allergic reactions, seek medical attention immediately.
For more information, consult your healthcare provider or refer to the official medication guide and reputable medical websites for detailed information about Austedo.
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