Axert is available in tablet form and is administered orally. Instructions regarding the use of Axert are not complicated, but it is always best to follow a prescription provided by your doctor.

Step-by-Step Instructions to Use:

Dosage: The inpatients receiving Axert start with a usual dose of 6.25 mg or 12.5 mg, taken at the onset of a migraine attack.

When the pain is not relieved in 2 hours, another dose can be received. However, no more than two doses should be taken within 24 hours. If the initial dose fails to have an effect, or if side effects occur, the doctor prescribing the drug may adjust the dose.

Taking the Tablet: Swallow the Axert tablet whole with a glass of water. It can be taken with or without food.

Missed Dose: If a dose is missed, it should not be taken. Patients should only take the medication at the onset of a migraine attack, and they should not take more than the prescribed amount.

The drug almotriptan, which is the active ingredient in Axert, derives its effect from the following mechanisms:

Serotonin Receptor Agonism: Almotriptan causes selective activation of serotonin receptors that exist in the brain. These are the 5-HT1 receptors responsible for modulation of blood vessel tone and neurotransmitter release, both of which are thought to participate in the migraine process.

Vasoconstriction: The classic migraine features include dilation or widening of the blood vessels found in the brain. Almotriptan constricts these blood vessels and helps relieve the pain experienced during this condition.

Inhibition of Mediators of Inflammation: It reduces the production of inflammatory mediators (like calcitonin gene-related peptide or CGRP) that increase the pain and agonizing sensations during the attack of a migraine. Axert helps to decrease the severity and also the duration of the migraine by reducing the inflammation.

Although Axert tends to be well tolerated, any side effects may be more likely when Axert is used at a higher dose or too frequently. Common side effects are:

Nausea: Some people may develop mild nausea after receiving Axert.

Dizziness or drowsiness: The person may experience dizziness or drowsiness after taking the medication.

Fatigue: Some patients may feel unusually tired or fatigued after ingesting Axert.

Severe side effects are uncommon but can occur, particularly in patients who have some type of pre-existing condition: –

Chest pain or chest tightness: Axert has been reported to cause cardiac side effects like chest pressure or pain. This is more likely to happen to those with a history of cardiovascular disease or who have risk factors.

Stroke or myocardial infarction: Despite the rarity, it has been associated with an increased risk of stroke or heart attack in patients who have pre-existing cardiovascular conditions.

Patients taking Axert should discuss any pre-existing medical condition or concern with their doctor. Warning and precaution include:

Cardiovascular conditions: Axert is contraindicated in a patient who has cardiovascular diseases, stroke, or uncontrolled hypertension. It should be avoided for any patients with peripheral vascular disease because the medication causes blood vessels to constrict, which will potentially worsen these illnesses.

Serotonin Syndrome: Using Axert with other drugs that have effects on serotonin levels, especially antidepressants, can lead to serotonin syndrome.

Kidney or liver disease: Significant impairment of both liver and kidneys may require a lower dose of Axert, and in some cases, the medication could be contraindicated.

Serotonergic Drugs: Combining Axert with other serotonin-enhancing medications like SSRIs, SNRIs, or MAO inhibitors may increase the risk of serotonin syndrome, a potentially life-threatening condition.

Ergotamine-Containing Medications: Co-administration with ergotamine or other ergot-related drugs can increase the risk of vasospastic reactions, such as severe hypertension or coronary artery spasm.

CYP3A4 Inhibitors: Drugs like ketoconazole or clarithromycin may increase almotriptan levels, leading to increased side effects or toxicity, necessitating dose adjustments.

Other Triptans: Using Axert with other triptans (e.g., sumatriptan) is not recommended due to an increased risk of cardiovascular events and compounded side effects.

The recommended dose of Axert for the acute treatment of a migraine attack is:

6.25 mg or 12.5 mg single dose, taken at the onset of a migraine.

If the migraine is not relieved within 2 hours, a second dose may be taken. However, no more than two doses should be taken in a 24-hour period.

Maximum dose: Do not exceed 25 mg in a 24-hour period.

It is important to follow the prescribed dosing instructions closely and avoid overuse to prevent medication-overuse headaches.

Axert is available only by prescription. Patients must consult with their healthcare provider, who will assess their medical history and current condition to determine if Axert is an appropriate medication for them.

 Axert is prescribed for those patients who experience frequent and severe migraine attacks that need acute treatment. 

Regular follow-up appointments are essential in monitoring the effectiveness of the treatment and preventing complications and side effects.

1. What is Axert?

   • Axert is a prescription medication used for the acute treatment of migraine headaches.

2. How does Axert work?

   • Axert works by narrowing the blood vessels around the brain, helping to relieve migraine symptoms.

3. What is the active ingredient in Axert?

   • The active ingredient in Axert is almotriptan.

4. What are the common side effects of Axert?

   • Common side effects may include nausea, dizziness, and fatigue.

5. Can Axert be used to prevent migraines?

   • No, Axert is intended for the acute treatment of migraines, not for prevention.

6. Who should not use Axert?

   • Individuals with a history of heart disease, high blood pressure, or certain types of migraine (like hemiplegic migraines) should avoid Axert.

7. What is the recommended dosage for Axert?

   • The typical starting dose is 6.25 mg or 12.5 mg; it can be taken as needed, but not more than two doses in 24 hours.

8. Is Axert safe to use during pregnancy?

   • The safety of Axert during pregnancy is not well-established; consult with a healthcare provider before use.

9. Can I take Axert with other medications?

   • Some medications may interact with Axert. Always inform your doctor about all medications you are taking.

10. What should I do if I miss a dose of Axert?

    • If you miss a dose, take it as soon as you remember, but do not take more than the prescribed amount in one day.

11. Can Axert be taken with food?

    • Yes, Axert can be taken with or without food.

12. What should I do if I experience severe side effects from Axert?

    • Seek immediate medical attention if you experience severe side effects such as chest pain or signs of an allergic reaction.

13. Is it possible to develop a tolerance to Axert?

    • Some patients may develop a tolerance, which can lead to reduced effectiveness over time.

14. How should Axert be stored?

    • Axert should be stored at room temperature and kept away from moisture and heat.

15. Where can I find more information about Axert?

    • Detailed information can be found in the medication guide provided with the prescription or from a healthcare provider.

16. Can Axert cause triptan sensations?

    • Yes, some individuals may experience sensations like tightness or pressure, which are associated with triptan medications.

17. Is Axert addictive?

    • Axert is not considered addictive, but it should be used as prescribed to avoid potential issues.

18. How long does it take for Axert to work?

    • Axert typically starts to relieve migraine symptoms within 30 to 60 minutes after taking it.

19. What should I do if I have a headache and my Axert is not working?

    • If Axert does not relieve your headache, consult your healthcare provider for alternative treatment options.

20. Can children use Axert?

    • Axert is not approved for use in children under 18 years of age unless prescribed by a healthcare provider.