Axiron should be administered exactly as prescribed by a healthcare provider. Generally, application of Axiron involves the following steps.

1. Before applying the solution on the underarm area, wash and dry it. Make sure the skin is clean and free from oils, lotions, or deodorants.

Step 2: Hold the Axiron applicator bottle upside and squeeze the right number of drops as prescribed with under your arm. A standard treatment dose consists of about 30 to 60 milligrams of testosterone, but this will depend on your doctor’s prescription.

Step 3: Allow the solution to dry completely before dressing. This helps ensure that all of the medication was absorbed through the skin and decreases the likelihood of it coming into contact with clothing or other people.

Step 4: After use, wash your hands with soap and water to avoid transferring the medication onto any other part of your body or onto another person.

Testosterone is a naturally produced male hormone that originates in the testes. This hormone plays a vital role in the development of male sexual function and overall health. In men with low testosterone levels, Axiron works to supplement the body’s natural testosterone; following application to the skin, the testosterone in Axiron is absorbed through the underarm and enters into the bloodstream, where it binds to androgen receptors in tissues all over the body.

Because these receptors are in the muscles, bones, and brain, it’s easy to see why testosterone has such a dramatic effect on health. The circulating levels of testosterone increase rapidly to alleviate the symptoms of testosterone deficiency, which includes fatigue, diminished libido, and decreased muscle mass. Over time, therapy restores testosterone levels to the normal range; it should help a patient feel more energetic, improve their mood, and generally improve physical performance.

Like any medication, Axiron can cause side effects, but not everyone experiences them. Common side effects of using Axiron include:

Skin reactions at the application site (irritation, redness, or itching)

It elevates red blood cells, known as polycythemia, which causes increased risks of thrombus

• Breast enlargement or tenderness
• Mood swings or irritability
• Acne or oily skin
• Headache
• Risk of sleep apnea is enhanced (in individuals at risk)
• The ankles or feet swelling called edema
• Sexual desire or functioning changes

Severe but rare side effects may include

• Chest pain or aching
• Shortness of breath
• Swelling of the face or hands

Risk of Transfer to Others: Axiron is applied topically; it carries a risk of transferring the drug to others through skin contact. This is especially careful when dealing with women or children. The patient should wash their hands immediately after they apply Axiron to avoid accidental transfer and to ensure that they avoid skin-to-skin contact with others in the application area.

Heart and Cardiovascular Health. Testosterone replacement therapy can increase the risk for heart attack, stroke, and other cardiovascular conditions, including heart disease in males with pre-existing conditions or risk factors.

Prostate Health. Testosterone replacement therapy can cause the prostate to enlarge. Patients with prostate cancer or a history of prostate disease must not use Axiron without first careful review with their prescribing physician.

Anticoagulants: Testosterone may enhance the effects of anticoagulants like warfarin, increasing the risk of bleeding. Regular monitoring of clotting parameters is recommended.

Insulin and Oral Hypoglycemics: Testosterone therapy may reduce insulin sensitivity, requiring adjustments to the dosage of insulin or oral hypoglycemic drugs for patients with diabetes.

Corticosteroids: When used together, corticosteroids and testosterone can increase the risk of edema and water retention, especially in patients with heart, kidney, or liver problems.

Other Hormonal Medications: Co-administration of other hormone therapies, such as corticosteroids or estrogen, may alter the effects of testosterone and necessitate close monitoring for adverse effects.

Axiron dosage is individualized depending on a patient’s testosterone levels, symptoms, and medical history. Typical starting dosages include 30 mg of testosterone (1 pump) applied to each underarm once daily. The dose may be adjusted by your doctor based on the response of your treatment, keeping in mind that blood testosterone levels should become normal.

The prescribed dosage should be strictly followed, and the quantity should never be changed without consulting a healthcare provider. Regular monitoring of testosterone levels is essential to determine whether the dose is appropriate and to check for any potential side effects.

Axiron may only be prescribed by a physician because it contains a controlled substance for the treatment of hypogonadism by intramuscular injection, which may cause abuse. For a prescription of Axiron, a healthcare provider will assess your symptoms, order blood tests to measure the level of testosterone, and confirm a diagnosis of hypogonadism. Once prescribed, the doctor would provide very specific instructions on how to properly use the medication safely and effectively.

Patients should not share their Axiron prescription with anyone else because the drug is only intended for the person who it has been prescribed to. It should also be filled out by a licensed pharmacy.

1. What is Axiron?

   • Axiron is a prescription medication used to treat adult males with low testosterone levels (hypogonadism). It is applied transdermally, specifically to the underarm area.

2. How does Axiron work?

   • Axiron works by supplementing testosterone, a hormone that plays a critical role in various bodily functions, including muscle mass, bone density, and sexual health.

3. How is Axiron applied?

   • Axiron is applied as a solution to the skin of the underarms. Each application delivers a measured dose of testosterone.

4. What are the common side effects of Axiron?

   • Common side effects include skin irritation at the application site, increased red blood cell counts, headache, and increased breast size (gynecomastia) in some men.

5. Who should not use Axiron?

   • Individuals with a known allergy to any of its ingredients, or those with prostate or breast cancer, should avoid using Axiron.

6. Can women use Axiron?

   • No, Axiron is not approved for use in women and can cause serious side effects if they are exposed to it.

7. How often should Axiron be applied?

   • Axiron should be applied once daily, preferably at the same time each day, to maintain stable hormone levels.

8. What should I do if I miss a dose of Axiron?

   • If you miss a dose, apply it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule.

9. Can Axiron affect fertility?

   • There is potential for testosterone therapy, including Axiron, to affect sperm production and fertility. Discuss any concerns with your healthcare provider.

10. Is there a significant risk of abuse with Axiron?

    • While Axiron is generally used for legitimate medical purposes, testosterone can be misused for performance enhancement, which poses risks.

11. What monitoring is required while using Axiron?

    • Patients should have regular follow-ups to monitor testosterone levels, blood count, and PSA levels, especially in older patients.

12. Can I shower or exercise after applying Axiron?

    • It’s best to let the solution dry before showering or exercising. It usually takes about 2 minutes to dry, after which water and sweat should not significantly impair the medication’s effectiveness.

13. What should I avoid while using Axiron?

    • Avoid applying Axiron to broken or irritated skin and refrain from transferring testosterone to others, particularly women and children.

14. Can Axiron interact with other medications?

    • Yes, Axiron may interact with certain medications, particularly those affecting hormone levels. Always inform your healthcare provider about all medications you are taking.

15. How long does it take to notice effects from Axiron?

    • Some men may start to notice improvements within a few weeks, but it could take up to 3-6 months to see the full effects.

16. What are some alternatives to Axiron?

    • Alternatives to Axiron include other testosterone replacement therapies such as injections, patches, gels, and pellets.

17. Can I use deodorant after applying Axiron?

    • Yes, you can use deodorant, but it’s best to apply it after Axiron has dried to prevent any potential interactions.

18. What happens if I apply too much Axiron?

    • Application of more than the prescribed amount may lead to increased side effects. Seek medical attention if an overdose is suspected.

19. Will my insurance cover Axiron?

    • Coverage varies by insurance plan. It’s advisable to check with your provider about coverage and any potential co-pays.

20. Where can I find more information about Axiron?

    • You can find more detailed information about Axiron from the prescribing information leaflet, your healthcare provider, or reputable medical websites.