AzaSite is available as an eye drop. Its use should be strictly guided by the healthcare provider’s prescription. The following is a general guideline on how to use AzaSite:

• Wash your hands before applying the medication in order not to contaminate it.
• Shake the bottle gently before use to ensure well-mixed medication.
• Tilt back your head and gently pull your lower eyelid down to form a small pocket.
• Place one drop of AzaSite into the affected eye(s), avoiding contact between the eye dropper tip and the eye to avoid contamination.
• Close your eye gently, then press on the inner corner of your eye near the nose to hold it closed for approximately 1 to 2 minutes to ensure that the drug stays in your eye.
• Rinse your hands with soap and water to remove any remaining medication after administering the drops.

Days 1–2: Instill 1 drop in the affected eye(s) b.i.d. (about 12 hours apart).

Days 3–5: Instill 1 drop in the affected eye(s) o.d.

Azithromycin works to block bacterial protein synthesis. In other words, it forms bonds with the 50S subunit of the ribosomes that result in the inability for bacterial elongation of these proteins that are necessary to develop. The bacteria lose the ability to reproduce because it can no longer produce any proteins.

Unlike most antibiotics, azithromycin has a relatively long half-life, which allows it to stay in the tissue longer and decrease the frequency of dosing. This property is very beneficial in treating localized infections such as bacterial conjunctivitis because it will allow for effective treatment with a shorter course of therapy.

AzaSite is usually well tolerated, but may cause some side effects. Common side effects include:

• Eye irritation or stinging upon instillation.
• Redness or itching of the eye.
• Blurred vision or temporary vision changes immediately following instillation.
• Dry eyes or sensation that something is in your eye.
• Headache or congestion in the sinuses occasionally.

More serious but very rare side effects could include:

Severe allergic reaction: Symptoms can include hives, swelling of your lips, tongue, or face, and difficulty breathing. Emergency attention should be sought if such symptoms occur.

Superinfection: Long-term use of antibiotics can lead to overgrowth of non-susceptible organisms, including fungi. If you have an allergic reaction or symptoms do not improve or worsen, contact your doctor.

Allergic Reactions: AzaSite should not be administered to you if you have a known allergy to azithromycin or any other macrolide antibiotics (such as clarithromycin or erythromycin).

Consecutively, conjunctivitis due to non-bacterial causes: AzaSite only works for the bacterial infections. It cannot be used to treat viruses, fungi, or allergy-induced conjunctivitis. This means the patient’s infection must be established as a bacterial one prior to use.

Contact Lenses Wear and remove contact lenses before applying AzaSite. Ointment eye drops may contain preservatives which can accumulate in contact lenses. Avoid wearing contact lenses until the infection has resolved and your eye symptoms have improved.

Pregnancy and Breastfeeding: AzaSite falls into Category B, which generally means that a drug is considered safe to use in pregnancy but may be used only if clearly needed. It is unknown whether azithromycin passes into breast milk; therefore, consult your physician before taking AzaSite if you are breastfeeding.

Other Macrolide Antibiotics: Combining AzaSite with other macrolide antibiotics (e.g., erythromycin, clarithromycin) can increase the risk of QT prolongation (an abnormal heart rhythm), which may lead to serious heart problems. It’s best to avoid this combination unless supervised by a healthcare provider.

Antacids Containing Aluminum or Magnesium: Taking antacids that contain aluminum or magnesium close to the time of using AzaSite can decrease the effectiveness of azithromycin. It’s recommended to space out the use of these medications by at least 2 hours.

Warfarin: If you are on warfarin (a blood thinner), Azithromycin can increase its effects, potentially leading to an increased risk of bleeding. Close monitoring of blood clotting levels (INR) is necessary when using these drugs together

Adults and Children over 1 year:

Days 1-2 Apply 1 drop into the affected eye(s) b.i.d.

Days 3-5: Instill 1 drop in the affected eye(s) once daily.

Infants under 1 year: AzaSite is generally not recommended for patients less than 1 year of age. Consult your physician for advice on the use of this product in children.

AzaSite is a prescription-only drug. It should be prescribed by a healthcare provider who would establish whether AzaSite suits the condition. It’s, therefore, important to use the prescribed dosage and period of treatment to ascertain whether the infection is cured entirely.

1. What is AzaSite?

   • AzaSite is a prescription eye drop solution containing azithromycin, primarily used to treat bacterial conjunctivitis (pink eye).

2. How does AzaSite work?

   • AzaSite works by inhibiting bacterial protein synthesis, which helps to eliminate the bacteria causing the infection.

3. What are the indications for AzaSite?

   • AzaSite is indicated for the treatment of bacterial conjunctivitis in adults and children.

4. How should AzaSite be administered?

   • The recommended dosage for AzaSite is typically one drop in the affected eye(s) twice daily for the first two days, followed by once daily for the next five days.

5. Are there any side effects associated with AzaSite?

   • Common side effects may include eye irritation, burning, stinging, and redness. Serious reactions are rare but can occur.

6. Can AzaSite be used with contact lenses?

   • It is recommended to remove contact lenses before using AzaSite and wait at least 15 minutes before reinserting them.

7. Is AzaSite effective against all types of eye infections?

   • AzaSite is specifically formulated for bacterial conjunctivitis and is not effective against viral infections or allergies.

8. Can children use AzaSite?

   • Yes, AzaSite is safe for use in children; however, proper dosing based on age should be followed.

9. Can I use other eye medications with AzaSite?

   • If using other eye drops, it is advisable to wait at least 5-10 minutes between administering the different medications.

10. How should AzaSite be stored?

    • AzaSite should be stored at room temperature, away from light and moisture, and should not be frozen.

11. What should I do if I miss a dose of AzaSite?

    • If you miss a dose, administer it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule.

12. Is AzaSite available over-the-counter?

    • No, AzaSite is a prescription medication and requires a doctor’s authorization.

13. Can AzaSite be used during pregnancy or breastfeeding?

    • Pregnant or breastfeeding individuals should consult their doctor before using AzaSite, as the effects during pregnancy are not fully established.

14. What should I do in case of an overdose?

    • In the event of an overdose, contact a healthcare provider or poison control. Overdose cases are rare with eye drops.

15. Can I experience any allergic reactions to AzaSite?

    • Although rare, some patients may experience allergic reactions. Symptoms may include rash, itching, or swelling. Seek medical attention if these occur.

16. How long does it take for AzaSite to start working?

    • Some patients may notice improvement within a few days of starting treatment, but it is essential to complete the prescribed course.

17. Are there any drug interactions with AzaSite?

    • There are no well-known major drug interactions, but always inform your healthcare provider about all medications you are taking.

18. What should I do if AzaSite gets in my mouth or nose?

    • If AzaSite accidentally gets into your mouth or nose, rinse thoroughly with water. If any adverse reactions occur, contact a healthcare provider.

19. Can AzaSite be used for conditions other than conjunctivitis?

    • AzaSite is specifically indicated for bacterial conjunctivitis and is not recommended for other uses without professional guidance.

20. How can I ask my doctor about AzaSite?

    • You can inquire about AzaSite by discussing your symptoms, writing down any questions you may have, and expressing your concerns with your healthcare provider.