| Common Brands | Azilect |
|---|---|
|
Drug Class |
MAO-B inhibitor |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Azilect is the brand name for rasagiline. It is a class of drugs known as monoamine oxidase inhibitors, or MAO inhibitors. Specifically, Azilect is a selective inhibitor of MAO-B, thereby acting as an inhibitor of monoamine oxidase type B. This enzyme is directly implicated in the breakdown process of dopamine in the brain. By inhibiting this MAO-B action, Azilect increases levels of dopamine in the brain of Parkinson’s disease patients, due to the loss of dopamine-producing neurons in the disease.
It is given as part of the regimen for the treatment of Parkinson’s disease, either as monotherapy or combined with levodopa and other medications. This drug is taken orally, preferably once a day in a tablet form.
Normally, Azilect is taken as tablet. The normal dose is 1mg taken once a day. Again, it depends on your medical professional for his or her prescription instruction. Here are some general guides:
General Dosage Information:
Starting dose: 1 mg daily.
Continuation dosing: Most patients continue at a daily dose of 1 mg, though the doctor will adjust dosing as appropriate based on individual patient response to medication.
Azilect may be taken with or without food. It is suggested to swallow the tablet intact with water. It should not be crushed, chewed, or divided.
If you miss one of your doses, use that dose immediately; if that has almost become time to administer the next dose of drug, omit the previously missed dose and resume regularly dosing as usual do not take an extra dosage. Combination Therapy
Azilect is sometimes prescribed together with levodopa (a dopamine precursor) for more effective symptom control, especially as the disease progresses and levodopa’s effects begin to wane.
Azilect is an inhibitor of the selective monoamine oxidase B (MAO-B) enzyme. This enzyme in the brain breaks down dopamine. In Parkinson’s disease, there is a lack of dopamine because of loss of the neurons that make dopamine; this is one of the reasons for its hallmark motor symptoms.
By inhibiting MAO-B, Azilect helps to increase the levels of dopamine available in the brain, which can improve symptoms related to dopamine deficiency.
The increased dopamine levels help enhance the activity of dopamine in the brain, leading to improvements in motor control, reducing symptoms such as tremors, muscle stiffness, and slowness of movement.
Moreover, there may be some neuroprotective activity of Azilect. There are studies that report that it can slow up the progression of Parkinson’s disease, and this study is still in its beginning stage.
Like any other medication, Azilect can cause side effects, but not everyone experiences them. Some of the common and serious side effects include:
Common Side Effects:
Serious Side Effects:
Serotonin Syndrome: Azilect, similar to other MAO inhibitors, can cause serotonin syndrome with other drugs that elevate serotonin levels, such as certain antidepressants like SSRIs, SNRIs, and tricyclic antidepressants. These include agitation, hallucinations, tachycardia, fever, muscle stiffness, and even tremors. Contact your doctor at once if you experience any of these symptoms.
Hypertension (High Blood Pressure): Azilect may induce high blood pressure, particularly when combined with certain other drugs, such as sympathomimetic drugs, including cold medications and decongestants. Prior to using Azilect with other drugs, a doctor’s advice is necessary.
Allergic Reactions: In rare cases, there is an allergic reaction to Azilect, and patients experience rash, swelling, or difficulty breathing. One should seek medical attention at such times.
Before beginning Azilect, one should inform the doctor about any of the following conditions:
Liver disease: Azilect is metabolized in the liver, and there may be a need for a lesser dose in patients with a history of liver disease.
Hypertension (High Blood Pressure): Azilect may induce or worsen high blood pressure, especially when it is combined with certain other medications or foods. Monitor your blood pressure regularly.
Serious cardiovascular conditions: If you have a history of heart problems or stroke, your doctor will assess whether it is appropriate to take Azilect.
Other medications: Some drugs like SSRIs, SNRIs, tricyclic antidepressants, and some antidepressants interact with Azilect and cause serotonin syndrome or dangerous high blood pressure. Always report all the drugs you are on to your doctor.
Monoamine Oxidase Inhibitors (MAOIs): Azilect should not be taken with other MAO inhibitors, including certain antidepressants like phenelzine or tranylcypromine, as this can lead to dangerous side effects like serotonin syndrome, which is a life-threatening condition.
Selective Serotonin Reuptake Inhibitors (SSRIs): Combining Azilect with SSRIs (e.g., fluoxetine, sertraline) may increase the risk of serotonin syndrome, causing symptoms like confusion, agitation, and high fever.
Dextromethorphan: Azilect should not be used with medications containing dextromethorphan (found in some cough medicines) due to the risk of serotonin syndrome.
The typical dose for Azilect is 1 mg once daily. Your doctor will adjust the dose according to your reaction to the treatment. You will be instructed by your doctor on the appropriate dosage adjustments when taking Azilect with levodopa to allow for optimal control of symptoms.
Note: Do not increase the dose more than prescribed. If you miss a dose, take it as soon as you remember, but you should never double up the doses to make up for a missed one.
Azilect is a prescription-only medication and should be prescribed by a healthcare provider who specializes in the treatment of Parkinson’s disease. Due to potential drug interactions and side effects, it is very important that you follow your healthcare provider’s instructions.
What is Azilect?
Azilect is the brand name for rasagiline, a medication used to treat Parkinson’s disease by increasing dopamine levels in the brain.
How does Azilect work?
Azilect inhibits the enzyme monoamine oxidase-B (MAO-B), which breaks down dopamine. By blocking this enzyme, it helps maintain higher levels of dopamine, improving motor function.
What are the common side effects of Azilect?
Common side effects include headache, joint pain, indigestion, nausea, and insomnia. Some individuals may experience more severe effects.
Can Azilect be taken alone or only with other medications?
Azilect can be used as monotherapy in early Parkinson’s disease or as an adjunct to levodopa in more advanced stages.
How should Azilect be taken?
It is usually taken once daily, with or without food. It’s important to follow your doctor’s instructions.
Are there any dietary restrictions while taking Azilect?
Yes, patients should avoid foods high in tyramine (like aged cheeses and cured meats) as they can cause hypertensive crises when taken with Azilect.
Can Azilect cause severe allergic reactions?
Although rare, it can cause allergic reactions such as swelling, rash, or difficulty breathing, requiring immediate medical attention.
Is it safe to use Azilect during pregnancy or breastfeeding?
The safety of Azilect in pregnancy and breastfeeding hasn’t been established. Consult your healthcare provider before use.
What should I do if I miss a dose of Azilect?
If you miss a dose, take it as soon as you remember unless it’s nearly time for your next dose. Do not double up on doses.
Can Azilect interact with other medications?
Yes, Azilect can interact with certain medications, including antidepressants and other MAO inhibitors. Always inform your doctor about all medications you are taking.
How long does it take for Azilect to start working?
Some patients may notice improvements within a week, but it can take several weeks for the full effects to become apparent.
What should I do if I experience severe side effects?
If you experience severe side effects such as chest pain, confusion, or unusual changes in mood or behavior, seek medical attention immediately.
Is Azilect prescribed for conditions other than Parkinson’s disease?
While its primary use is for Parkinson’s disease, some studies have explored its potential in treating other neurological disorders, but it is not widely prescribed for them.
Can Azilect affect my ability to drive?
Azilect may cause dizziness or drowsiness in some patients, which could impair driving ability. Speak with your doctor about your specific situation.
How should Azilect be stored?
Store Azilect at room temperature away from light and moisture, and keep it out of reach of children.
Is regular monitoring required while taking Azilect?
Yes, regular check-ups are important to monitor the effectiveness of the medication and any potential side effects.
What should I tell my doctor before starting Azilect?
Inform your doctor about all medical conditions, allergies, and medications you are currently taking, especially antidepressants and other MAO inhibitors.
Can Azilect be stopped abruptly?
Stopping Azilect suddenly can cause withdrawal symptoms or worsening of Parkinson’s disease symptoms. Consult your doctor for a proper discontinuation plan.
Is there a risk of serotonin syndrome when taking Azilect?
Yes, there is a risk of serotonin syndrome, especially if taken with other medications that increase serotonin levels. Be vigilant for symptoms like confusion, agitation, or rapid heartbeat.
Where can I find more information about Azilect?
For more information, consult your healthcare provider or visit reputable medical websites, such as the FDA or the National Institutes of Health.
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