| Common Brands | Azopt |
|---|---|
|
Drug Class |
Carbonic anhydrase inhibitor |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Azopt is a medication that is often prescribed for the treatment of increased intraocular pressure (IOP) in patients with specific eye conditions, like glaucoma and ocular hypertension.
The above-mentioned conditions are caused by increased pressure within the eye, which may eventually result in damage to the optic nerve and even vision loss if left untreated.
Azopt is in a class of drugs called carbonic anhydrase inhibitors. These are drugs that inhibit the production of aqueous humor, which is the fluid inside the eye and contributes to intraocular pressure
Azopt is for topical ophthalmic use only. Patients should administer the medication according to their health provider’s instructions or as the package insert directs. In general, the following are the directions for using Azopt.
Wash your hands with soap and water before putting in the eye drops. Open the bottle and shake the medication gently before applying.
Tip back the head and pull down the lid of your lower eye for it to form a small pocket.
Put in the number of drops as prescribed in the pocket of your lower eye. Usually, one drop in each affected eye, but your doctor may suggest otherwise depending on your diagnosis.
Close your eye after instillation for a minute or two to allow it to absorb.
Do not touch the dropper to any surface, eye, or other contact lenses.
Always wash your hands after using the drops to ensure that there is no medication left on your skin.
The active ingredient in Azopt is a carbonic anhydrase inhibitor called brinzolamide. Carbonic anhydrase is an enzyme within the eye that produces aqueous humour, the fluid that keeps intraocular pressure steady. In normal functioning of the eye, aqueous humour is constantly produced by the ciliary body, circulating within the eye and leaving through various pathways.
Brinzolamide reduces the activity of carbonic anhydrase in the ciliary body. The decrease in enzymatic activity decreases the production of aqueous humor. This decrease reduces the volume of fluid in the eye, thus lowering the intraocular pressure. By limiting the intraocular pressure, Azopt prevents the further degeneration of the optic nerve that could result in loss of vision in glaucoma patients.
Like all medications, Azopt can cause side effects. However, not everyone experiences them. Common side effects of Azopt may include:
Blurry Vision: Dilation of pupils causes transient blurred vision, especially soon after instillation.
Dry Eyes: Some patients might suffer from dryness and discomfort in the eyes.
Bitter Taste: Taste in the mouth is metallic bitter due to the possibility of oozing of medicine down the throat.
Headache: Some patients experience headaches with Azopt.
More serious side effects are rare, but can happen. They include:
Eye Infections: Sometimes, a patient may develop eye infections or inflammation, and more medication may be required.
Change in Vision: If a vision change is not temporary, this should be reported to a healthcare provider immediately.
Important warnings and precautions related to Azopt are as follows:
Hypersensitivity: Patients suffering from hypersensitivity reactions with brinzolamide, sulfonamides, or any other component present in Azopt should avoid taking this medication.
Pregnancy and Breastfeeding: Azopt should be used during pregnancy or breastfeeding only if the potential benefits outweigh the risks. Always consult a healthcare provider before using any medication during pregnancy or while breastfeeding.
Combination Therapy: Azopt may be prescribed in combination with other antiglaucoma drugs. However, it should be taken with a doctor’s prescription to avoid drug interaction and ensure effectiveness of combination therapy.
Carbonic Anhydrase Inhibitors: Concurrent use of Azopt with oral carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of systemic side effects like metabolic acidosis and electrolyte imbalances.
Corticosteroids: Use of corticosteroids may increase the risk of adverse reactions such as fluid and electrolyte imbalances, especially when combined with Azopt.
Diuretics: Diuretics, particularly those that cause potassium loss, may exacerbate Azopt-related electrolyte disturbances like hypokalemia.
Topical Medications: Combining Azopt with other topical ophthalmic medications may increase the risk of eye irritation or reduced efficacy, so it’s essential to space out doses.
One drop is instilled into the affected eye(s) every once or twice daily. Exact dosing schedule may differ according to condition and response by patient.
Adults- one drop in the affected eye(s) once or twice a day;
Pediatric usage: generally not recommended under the age of 18, though it may sometimes be given to children based on recommendations from a prescribing physician.
Patients should take the prescribed dose and frequency to achieve optimal results. If a dose is missed, it should be taken as soon as remembered unless it is close to the time for the next dose. In that case, the missed dose should be skipped.
Azopt is an RX medication and needs a doctor’s prescription. There must be a thorough exam by an eye care practitioner to determine if the person will need Azopt treatment. A healthcare provider has to assess the severity of intraocular pressure, and whether there are preexisting conditions in the eyes and even other medications that a person is taking before he can offer a prescription for Azopt.
The healthcare provider should be provided with a complete medical history, including any history of kidney or liver disease, for the safe use of Azopt.
What is Azopt?
Azopt is a prescription eye drop medication containing the active ingredient brinzolamide, used to reduce intraocular pressure in patients with glaucoma or ocular hypertension.
How does Azopt work?
Azopt works by inhibiting the enzyme carbonic anhydrase, which decreases the production of aqueous humor in the eye, leading to lower intraocular pressure.
What conditions is Azopt used to treat?
Azopt is primarily used to treat open-angle glaucoma and ocular hypertension.
Who can use Azopt?
Adults and children over the age of 2 can use Azopt, but it is important to consult with a healthcare provider for pediatric use.
How should I use Azopt?
Follow your healthcare provider’s instructions, typically applying one drop to the affected eye(s) one to three times a day.
Can I use Azopt with other eye medications?
Yes, but it is essential to space out the application of different eye drops by at least 10-15 minutes and consult your healthcare provider for proper management.
What are the common side effects of Azopt?
Common side effects may include burning or stinging in the eye, blurred vision, dry eyes, and irritation.
Are there any serious side effects associated with Azopt?
Serious side effects are rare but can include allergic reactions or changes in vision. Seek medical help if you experience severe symptoms.
Can I use Azopt if I am pregnant or breastfeeding?
You should consult your healthcare provider if you are pregnant or breastfeeding, as the effects on the fetus or infant are not fully established.
How long does it take for Azopt to work?
Some patients may notice a decrease in intraocular pressure within a few hours, but optimal results may take several days of consistent use.
What should I do if I miss a dose of Azopt?
If you miss a dose, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not double up.
Is Azopt safe for people with contact lenses?
It is advised to remove contact lenses before using Azopt and wait at least 15 minutes after applying the drops before reinserting them.
Can Azopt cause color changes in the iris?
No, Azopt does not affect the color of the iris, unlike some other glaucoma medications.
What should I do if I experience discomfort after using Azopt?
If you experience persistent discomfort, worsening symptoms, or visual changes after using Azopt, contact your healthcare provider for advice.
Can Azopt affect vision?
Some patients may experience temporary blurred vision immediately after applying Azopt. This usually resolves quickly.
How should I store Azopt?
Store Azopt at room temperature in a tightly closed container, away from light, and do not freeze. Keep it out of reach of children.
What is the expiration date for Azopt after opening?
After opening, Azopt should generally be used within 28 days; check the package for specific expiration details.
Are there any contraindications for using Azopt?
Azopt should not be used by individuals with a known allergy to brinzolamide or other components of the formulation, or those with severe kidney problems.
Is Azopt a controlled substance?
No, Azopt is not classified as a controlled substance.
Where can I obtain Azopt?
Azopt is available by prescription at pharmacies and may also be ordered through online pharmacies with a valid prescription.
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