Baqui-Simli is delivered as a nasal powder using a single-dose delivery device. This drug is intended for the self-administration of people with diabetes or their caregivers during an acute hypoglycemic episode.

• Take Baqui-Simli out of its package and expose the nasal device. 
• Insert the nozzle into one of the nostrils.
• Press the device firmly so that the full dose of the nasal powder goes into the nostril. Do not inhale or breathe in at the time of administration

After the dose has been administered, dispose of the device. The device is a single use and the device contains the full dose.

Baqsimi is a glucagon delivered through the nasal mucosa to directly enter the bloodstream. When administered, glucagon activates the liver to discharge stored glucose into the blood, a process that raises blood sugar levels and reverses the symptoms of severe hypoglycemia.

Stimulation of Glycogen Breakdown: Glucagon stimulates the liver to break down glycogen, that is, the stored glucose, and release glucose into the blood to raise the blood sugar levels.

Balancing Hypoglycaemia: Baqsimi works by rapidly boosting the blood glucose levels; thus, it corrects the dangerous low blood glucose levels caused by factors like overdose of insulin, neglecting meals, or heavy exercise.

Baqui-Simli works rapidly within a 10-minute window from injection to alleviate symptoms of severe hypoglycemia, such as confusion, shakiness, and loss of consciousness.

While Baqsimi is generally well tolerated, it can cause side effects in some individuals. Common side effects include:

There may be nasal irritation, such as a dry nose or sore throat, in some patients who use Baqsimi.

Headache: Some patients also develop headache after the use of Baqsimi.

Nausea or Vomiting: Some patients may experience nausea or even vomiting in rare cases, especially if blood glucose levels are corrected too fast.

Dizziness: Dizziness or dizziness can be experienced, especially if the patient has severely low blood sugar levels during treatment.

Allergic Reactions: Although rare, allergic reactions such as rash, itching, or swelling can occur. Medical attention should be sought immediately if any signs of an allergic reaction appear.

Should Not Be Used in Patients with Pheochromocytoma: Baqsimi should not be administered in patients with pheochromocytoma-a rare tumor of the adrenal gland-because it could result in dangerous elevations of blood pressure.

Precautions in Patients with Epilepsy: Even though Baqsimi successfully corrects hypoglycemia, patients with hypoglycemic seizures require further medical management. Patients who have persistent seizure activity following administration of Baqsimi require immediate medical care.

Effectiveness in Severe Hypoglycemia: Baqsimi works for most patients suffering from hypoglycemia, but there should always be follow-up with the patient after using the medication. If they fail to show any response or recover within 15 minutes, more intensive medical care will be needed.

Pregnancy and Breastfeeding: Information is limited about the use of Baqsimi in pregnancy or breastfeeding. It is only to be used in pregnancy if potential benefits justify the potential risks. Always consult a health care provider before using Baqsimi during pregnancy or breastfeeding.

1. Beta-blockers: Concurrent use of Baqsimi Nasal Powder and beta-blockers (like propranolol) may increase the risk of hypoglycemia (low blood sugar). Monitor blood sugar levels closely when using both medications together.
2. Antidiabetic Medications: Using Baqsimi with other antidiabetic drugs, such as insulin or sulfonylureas, may enhance the risk of hypoglycemia. Adjustments in the dosage of antidiabetic medication may be necessary to prevent low blood sugar levels.
3. Thiazide Diuretics: Thiazide diuretics (such as hydrochlorothiazide) can decrease the effectiveness of Baqsimi, potentially reducing its ability to raise blood sugar quickly. It’s essential to monitor glucose levels when using both medications.
4. Corticosteroids: The use of corticosteroids may reduce the effectiveness of Baqsimi Nasal Powder in raising blood sugar during hypoglycemic events. Proper monitoring and dose adjustments might be required.

Baqsimi is a single dose of 3 mg of glucagon provided by the nasal spray. A typical dose is administered by the following:

Adults and Children 4 years and older:  A single spray (3 mg) in one nostril of Baqsimi should be administered in the case of severe hypoglycemia.

If the person does not respond to the Baqsimi treatment within 15 minutes of its administration, medical aid should be sought immediately; another dose may be prescribed.

Follow the instructions about use carefully and do not administer extra doses unless they are prescribed by a physician.

Baqsimi is available only by prescription. Patients with diabetes or their caregivers should work with a healthcare provider to ensure proper use of Baqsimi and education on how to respond to severe hypoglycemia. A doctor will assess the patient’s condition and discuss appropriate emergency response measures for hypoglycemic events before prescribing Baqsimi.

1. What is Baqsimi Nasal Powder?

   • Baqsimi is a nasal powder formulation of glucagon used for the treatment of severe hypoglycemia (low blood sugar) in individuals with diabetes.

2. How does Baqsimi work?

   • Baqsimi raises blood sugar levels by stimulating the liver to release glucose into the bloodstream, counteracting the effects of insulin.

3. Who is Baqsimi intended for?

   • Baqsimi is prescribed for adults and children aged 4 years and older who are at risk of severe hypoglycemia and require rapid treatment.

4. How is Baqsimi administered?

   • Baqsimi is administered as a single spray into one nostril. Patients or caregivers do not need to prime the device before use.

5. What should I do if I experience a hypoglycemic episode?

   • In a hypoglycemic episode, promptly administer Baqsimi into one nostril. It is critical to seek medical attention even after using Baqsimi.

6. What are the common side effects of Baqsimi?

   • Common side effects may include nausea, vomiting, headache, dizziness, and nasal discomfort. Most side effects are mild and temporary.

7. Is Baqsimi safe for children?

   • Yes, Baqsimi is approved for use in children aged 4 years and older for treating severe hypoglycemia.

8. Can Baqsimi be used in place of glucose?

   • Baqsimi is not a substitute for glucose or carbohydrate intake; it is intended for treating severe hypoglycemia when immediate action is needed.

9. What should I do if I miss a dose of Baqsimi?

   • Baqsimi is used as needed during hypoglycemic events, so there is no scheduled dosing to “miss.” However, administer it when symptoms of severe hypoglycemia arise.

10. How should Baqsimi be stored?

    • Baqsimi should be stored at room temperature (20°C to 25°C or 68°F to 77°F) and protected from light. Do not freeze or refrigerate.

11. Does Baqsimi require a prescription?

    • Yes, Baqsimi is a prescription medication and should be used under the guidance of a healthcare provider.

12. Can Baqsimi interact with other medications?

    • Baqsimi is primarily glucagon, and potential interactions are minimal, but it’s important to inform your healthcare provider about all medications you are taking.

13. Are there any contraindications for using Baqsimi?

    • Baqsimi should not be used in patients with a known allergy to glucagon or any of its components. Always consult a healthcare provider before use.

14. What do I do if the Baqsimi device appears damaged?

    • If the Baqsimi device is damaged or if you have concerns about its integrity, do not use it and contact your pharmacist or healthcare provider for a replacement.

15. How fast does Baqsimi work?

    • Baqsimi typically begins to work within 10 minutes, but full effects may vary per individual. Monitor blood sugar levels closely after administration.

16. Can Baqsimi be used during pregnancy?

    • Consult a healthcare provider about using Baqsimi during pregnancy. While there are no specific contraindications, careful consideration is necessary.

17. Is Baqsimi suitable for people with renal or liver issues?

    • Those with severe renal or liver impairment should consult a healthcare provider before using Baqsimi, as special care and monitoring might be needed.

18. Can Baqsimi cause a hyperglycemic reaction?

    • While Baqsimi is intended to raise blood sugar levels, its misuse or over-administration could potentially lead to hyperglycemia. Always follow prescribed guidelines.

19. What happens if my symptoms do not improve after using Baqsimi?

    • If symptoms of hypoglycemia persist after using Baqsimi, seek emergency medical assistance immediately. A second dose may be necessary.

20. Where can I access more information about Baqsimi?

    • For more detailed information, consult your healthcare provider, visit the official Baqsimi website, or refer to the product’s patient information leaflet.