| Common Brands | Kinnate |
|---|---|
|
Drug Class |
Immunosuppressant |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Belumosudil (brand name: Rezurock) is a prescription drug that is used to treat rare and serious conditions, especially chronic graft-versus-host disease (cGVHD). This drug was developed to help manage this condition in patients who have not responded adequately to previous therapies. Belumosudil is a selective inhibitor of the ROCK2 (Rho-associated coiled-coil kinase 2) enzyme, a key player in immune cell signaling that contributes to inflammation and fibrosis seen in cGVHD.
The drug is an oral drug that was approved by the U.S. Food and Drug Administration in 2021 for the treatment of chronic graft-versus-host disease, providing a new option for patients suffering from this condition.
Belumosudil is an oral medication that is taken in the form of a tablet. The recommended dosage and administration guidelines are as follows:
Administration: Belumosudil is administered orally, with or without food. The tablet should be swallowed whole and not chewed, crushed, or split.
Missed Dose: If a dose is missed, take it as soon as remembered, but if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Storage: Keep Belumosudil at room temperature. Keep it away from moisture and heat. Store out of the reach of children.
Belumosudil is an inhibitor of ROCK2 (Rho-associated coiled-coil kinase 2), which is a protein that has a role in regulating cellular functions, such as inflammation, cell migration, and tissue remodeling. The protein plays a central role in the activation of immune cells that are integral to the pathogenesis of graft-versus-host disease.
In cGVHD, the immune cells of the donor’s graft attack the recipient’s tissues, leading to chronic inflammation and tissue damage. Belumosudil works by inhibiting ROCK2, thus reducing the activity of these immune cells, particularly T cells, which are major drivers of the immune response in cGVHD
Belumosudil like other medications triggers side effects. Among some the common as well as some serious side effects include:
Diarrhea: It is one of the most frequent side effects of Belumosudil. This can be severe at times and needs to be treated.
Infections: Belumosudil has the potential to increase infections since it suppresses the immune system, including upper respiratory tract infections, urinary tract infections, and fungal infections.
Fatigue: Many patients reported experiencing tiredness or fatigue during the administration of Belumosudil.
Liver Toxicity: Belumosudil can lead to liver-related side effects such as increased liver enzymes. Liver function should be monitored during treatment.
There are several important warnings and precautions to consider before beginning treatment with Belumosudil:
Risk of Infections: As Belumosudil inhibits the immune response, the risk of infection increases. Patients must be closely observed for symptoms of infection and appropriate treatment given in case of infection.
Liver Toxicity: Belumosudil is known to induce liver toxicity, and patients undergoing the treatment should undergo regular checkup of their liver functions. High liver enzymes or manifestations of liver disease must be treated promptly.
Pregnancy and Breastfeeding: It is classified as a pregnancy category C drug meaning that it may cause harm to the developing fetus. It is appropriate to use during pregnancy if the potential benefit outweighs the risks. It is not established whether Belumosudil passes into breast milk and, therefore, its usage is contraindicated in breastfeeding patients.
Blood Cells: The medication Belumosudil has a propensity to affect the blood cell count, that is red cells, white cells, and platelets. Periodical tests on the blood cell counts may be carried out during treatment.
Immunosuppressants: Using Belumosudil with other immunosuppressive medications may increase the risk of infections due to a weakened immune system, requiring extra monitoring.
Liver Enzyme Inhibitors: Drugs like ketoconazole or ritonavir may increase the levels of Belumosudil in the body, potentially leading to side effects like liver problems.
Chemotherapy Drugs: When combined with other cancer treatments or chemotherapy drugs, Belumosudil may increase the risk of bone marrow suppression, leading to low blood cell counts.
Blood Thinners: Belumosudil may enhance the effects of blood thinners, raising the risk of bleeding or bruising.
The usual recommended dosage of Belumosudil for cGVHD is 200 mg per day, orally. It must be taken as directed. Therefore, your healthcare provider may administer dosages adjusted according to one’s response to the treatment and other side effects he may be experiencing.
If a dose is missed, the patient should take it as soon as they remember it; if it is almost time to take the next dose, they should skip it and continue with the scheduled dosing at the appropriate time. Double dosing should be avoided.
Belumosudil is a prescription drug; it can only be prescribed by a licensed healthcare provider. The decision to prescribe Belumosudil is usually based on the patient’s medical condition, the severity of their chronic graft-versus-host disease, and the response of the patient to previous treatments.
Before starting the treatment with Belumosudil, doctors will check the medical history of the patient, carry out the necessary tests (like liver function tests), and confirm that they are the right candidates for this therapy.
What is Belumosudil?
Belumosudil is a medication used to treat chronic graft-versus-host disease (cGVHD) in patients who have received a stem cell transplant.
How does Belumosudil work?
Belumosudil is a selective inhibitor of the enzyme ROCK2, which plays a role in regulating immune responses and inflammation in the body.
Who can take Belumosudil?
Belumosudil is prescribed for adults and pediatric patients aged 12 years and older who are experiencing cGVHD after receiving a stem cell transplant.
What is the recommended dosage for Belumosudil?
The typical starting dose for Belumosudil is 200 mg taken orally once daily, but your healthcare provider may adjust it based on your response to treatment.
What are the common side effects of Belumosudil?
Common side effects may include diarrhea, nausea, fatigue, and elevated liver enzymes.
Are there any serious side effects associated with Belumosudil?
Serious side effects can include liver problems, infections, and gastrointestinal issues, which should be monitored by your healthcare provider.
Is Belumosudil a controlled substance?
No, Belumosudil is not classified as a controlled substance.
How long can I take Belumosudil?
The length of treatment with Belumosudil will depend on your individual condition and response to therapy, as determined by your healthcare provider.
Can I take Belumosudil with other medications?
You should inform your healthcare provider about all medications you are taking, as Belumosudil may interact with certain drugs.
Can Belumosudil be used in children?
Yes, Belumosudil is approved for use in pediatric patients aged 12 years and older who have cGVHD.
What should I do if I miss a dose of Belumosudil?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take two doses at once.
Does Belumosudil affect my ability to drive?
Belumosudil may cause side effects such as fatigue and dizziness, which could impair your ability to operate machinery or drive. It is advisable to assess your response before engaging in such activities.
What precautions should I take while using Belumosudil?
Regular monitoring of liver function and screening for infections is important while taking Belumosudil, as well as practicing good hygiene to reduce infection risk.
Can I drink alcohol while taking Belumosudil?
It is advisable to talk to your healthcare provider about alcohol consumption while on Belumosudil, as it may affect liver function.
How does Belumosudil compare to other treatments for cGVHD?
Belumosudil is a targeted therapy specifically for cGVHD, and its effectiveness may differ from other corticosteroids or systemic therapies traditionally used for treating this condition.
Are there any dietary restrictions while taking Belumosudil?
No specific dietary restrictions are required while taking Belumosudil, but maintaining a balanced diet is advisable. Always consult your healthcare provider for personalized advice.
What should I tell my doctor before starting Belumosudil?
Inform your doctor about your complete medical history, including any liver conditions, infections you may have had, and medications you are currently taking.
Can I stop taking Belumosudil suddenly?
Always consult your healthcare provider before stopping Belumosudil, as they will guide you on how to safely discontinue or adjust dosing.
Is Belumosudil covered by insurance?
Coverage for Belumosudil may vary based on your insurance plan, so it is best to check with your provider for more information.
Where can I find more information about Belumosudil?
Additional information can be found through your healthcare provider, the pharmacy, or reputable medical resources and websites.
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