| Common Brands | Calcitrene, Sorilux, Trionex |
|---|---|
|
Drug Class |
Vitamin D analogue
|
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Calcitrene is a topical medication that contains calcipotriene, a synthetic derivative of vitamin D3. It is primarily used for the treatment of psoriasis, a chronic autoimmune condition characterized by the rapid growth of skin cells, leading to the formation of thick, scaly patches on the skin. Calcitrene helps to manage psoriasis by modulating the growth and differentiation of skin cells, reducing the buildup of skin cells that cause these plaques.
Calcitrene is primarily recommended in combination with other treatments, so that topical treatments can control it when there are symptoms or breaks. It is usually used applied topically in the form of an ointment or a cream for the lesions sites.
Calcitrene can be applied topically to the affected areas of the skin as a cream or ointment. Apply it as follows:
Clean and dry the affected area before applying the medication.
Apply a thin layer of Calcitrene to the affected skin areas, usually once or twice daily, as directed by the healthcare provider. Be sure to follow the prescribed frequency and avoid using more than the recommended amount.
Rub the medication gently into the skin until it is fully absorbed. Be careful not to apply the medication to open wounds, cuts, or other areas where the skin is broken.
Avoid contact with eyes, mucous membranes, and other sensitive areas such as the face and genital region unless specifically advised by a healthcare provider.
Wash your hands thoroughly after applying Calcitrene to avoid touching other parts of the body or sensitive areas.
Adhere to your doctor’s advice on the duration of treatment because using the medication for too long or more than required may cause side effects such as skin irritation.
The mechanism of action of Calcitrene (calcipotriene) is that it regulates the proliferation and differentiation of keratinocytes. Keratinocytes in psoriasis proliferate excessively and do not mature appropriately, causing the plaques and scales characteristic of the condition. Calcipotriene acts by:
Binding to Vitamin D receptors: Calcipotriene binds to vitamin D receptors on the surface of keratinocytes. This binding leads to a cascade of actions that govern the growth, differentiation, and apoptosis of skin cells.
Normalizing Cell Growth: Calcipotriene inhibits the rapid proliferation of keratinocytes, leading to a more regulated skin cell turnover. This reduces the thickening and scaling of the skin that is typical in psoriatic lesions.
While Calcitrene is well tolerated, it can still induce some side effects. The common side effects are generally mild and include the following:
Skin Irritation: Users may experience irritation, burning, stinging, or redness and itchiness on the application site during the initial treatment. These usually only are temporary as the skin gets adapted to the medication.
Dryness or Peeling: As the drug works to normalize skin turnover, users may experience dryness, peeling, or mild flaking of the skin in the treated areas.
Skin Sensitivity: Prolonged use of Calcitrene may cause the skin to become more sensitive, and excessive exposure to sunlight or ultraviolet (UV) light may increase the risk of sunburn or skin damage.
Allergic Reactions-Some patients might suffer allergic reactions. Though quite rare, the reactions can range from severe rash, itching, or swelling. Patients should, therefore seek medical attention when such symptoms arise and stop using the drug.
Before using Calcitrene, there are some precautions to be taken:
Do not use too much: Taking too much of the drug or applying it to a wide area of skin will raise the risk for developing hypercalcemia among others. Use the medication precisely as directed.
Sun exposure: Because calcipotriene may cause skin sensitivity to sunlight, sun exposure should be avoided as well as using sunscreen while out in the sun.
Skin Infections: Apply calcitrene to only those skin areas without open wounds, infection, or active skin infections.
Pregnancy and Breastfeeding: It is not established whether Calcitrene is safe or not during pregnancy and breastfeeding. A healthcare provider should be consulted in case of pregnancy or breastfeeding prior to initiating treatment.
Kidney Function: If you suffer from kidney problems or any other medical condition, a doctor should be consulted prior to using Calcitrene, as it may affect the metabolism of calcium.
Topical Corticosteroids: Using calcipotriol (Calcitrene) with topical corticosteroids (e.g., hydrocortisone) on the same area of the skin may increase the absorption of both medications. This could heighten the risk of side effects like skin thinning or systemic effects due to increased absorption.
Calcium Supplements: Since calcipotriol is a form of Vitamin D, it can enhance calcium absorption in the body. When used with calcium supplements (e.g., Calcium 500 + D), it may increase the risk of hypercalcemia (high blood calcium levels). Monitoring calcium levels is recommended.
Thiazide Diuretics: Thiazide diuretics (e.g., hydrochlorothiazide) can cause calcium retention in the kidneys. When combined with calcipotriol, the risk of hypercalcemia may be heightened. Regular monitoring of calcium levels is advised.
Other Vitamin D Derivatives: Combining calcipotriol with other forms of Vitamin D (e.g., calcitriol, ergocalciferol) or its analogs can increase the risk of elevated calcium levels and potential toxicity. It’s essential to monitor blood calcium levels closely to prevent hypercalcemia.
Adults: The usual application schedule for Calcitrene is one to two times a day at the same time on, and it depends on the recommendation of the healthcare provider, taking in mind the severity of the cases and individual response to treatment.
Maximum Exposure: Usually, Calcitrene should not be exposed to more than 30% of the body surface area. In severe cases of psoriasis, the healthcare provider might advise the use of other medication alongside Calcitrene.
Length of Treatment: This length of treatment is expected to be followed by a health care provider. Exposing your skin to more periods beyond the recommended length might make the skin condition develop side effects or less response.
Calcitrene is a prescription drug, and to acquire it, one has to have a doctor’s prescription. A healthcare provider will assess the patient’s severity of psoriasis, previous treatments, and all health conditions before prescribing Calcitrene. Patients must take their doctor’s prescriptions seriously and report any changes or side effects.
What is Calcitrene?
Calcitrene is a synthetic form of calcitriol, which is the active form of vitamin D. It is primarily used in dermatology to treat certain skin conditions.
What conditions is Calcitrene used to treat?
Calcitrene is primarily used to treat psoriasis, a skin condition characterized by the rapid growth of skin cells leading to scaling and inflammation.
How does Calcitrene work?
Calcitrene works by binding to vitamin D receptors in the skin, which helps to regulate skin cell growth and reduce inflammation.
How is Calcitrene administered?
Calcitrene is typically administered as a topical ointment or cream that is applied directly to the affected areas of the skin.
What are the common side effects of Calcitrene?
Common side effects include skin irritation, burning, itching, or dryness at the application site.
Is Calcitrene safe for long-term use?
Long-term use should be monitored by a healthcare professional, as prolonged use may increase the risk of skin irritation or other side effects.
Can Calcitrene be used with other psoriasis treatments?
Yes, Calcitrene can often be used in combination with other treatments, but it’s essential to consult a healthcare provider for personalized advice.
Who should avoid using Calcitrene?
Individuals with hypersensitivity to calcitriol or any of the other ingredients in the formulation should avoid using Calcitrene.
Can pregnant or breastfeeding women use Calcitrene?
Pregnant or breastfeeding women should consult with their healthcare provider before using Calcitrene to ensure safety for themselves and the child.
How should Calcitrene be stored?
Calcitrene should be stored at room temperature, away from excess heat and moisture, and kept out of reach of children.
What happens if a dose of Calcitrene is missed?
If a dose is missed, apply it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and continue with your regular schedule.
Can Calcitrene cause allergic reactions?
While rare, some individuals may experience an allergic reaction. Symptoms may include rash, itching, or swelling. If these occur, seek medical attention.
Is Calcitrene effective for all types of psoriasis?
Calcitrene is primarily effective for plaque psoriasis but may not be suitable for other types of psoriasis. A healthcare provider can recommend the best treatment.
How quickly can results be seen with Calcitrene?
Patients may start to notice improvements in their psoriasis symptoms within a few weeks of regular use, but individual results can vary.
Can Calcitrene affect calcium levels in the body?
Calcitrene is designed primarily for topical use, so systemic absorption and effects on calcium levels are minimal. However, patients should be monitored if using high doses.
Are there any dietary restrictions while using Calcitrene?
There are no specific dietary restrictions associated with Calcitrene, but maintaining a balanced diet that supports skin health is advisable.
What should I do if Calcitrene irritates my skin?
If irritation occurs, discontinue use and consult a healthcare provider. They may recommend alternative treatments or ways to manage the irritation.
How does Calcitrene compare to other topical treatments for psoriasis?
Calcitrene may be more effective for some patients compared to other treatments like corticosteroids, but this varies based on individual response.
Can Calcitrene be used in children?
Calcitrene can be used in children, but the safety and effectiveness should be assessed by a healthcare provider.
Where can Calcitrene be obtained?
Calcitrene is typically available by prescription at pharmacies, and it should be dispensed only under the guidance of a healthcare professional.
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