| Common Brands | Cardura, Cardura XL |
|---|---|
|
Drug Class |
Alpha antagonist |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Cardura XL is a trade name of doxazosin, which is an extended release of an alpha-1 adrenergic blocker used to treat patients who are suffering from hypertension, among other diseases, including BPH. Unlike the immediate-release form of doxazosin, Cardura XL is a once-daily preparation that provides controlled release of the drug over a longer period, helping to maintain consistent therapeutic levels in the bloodstream throughout the day. This makes it a preferred option for patients who need continuous blood pressure or BPH management but prefer the convenience of once-daily dosing.
This product, essentially in an extended-release formula, will block alpha-1 receptors in the smooth muscle cells of the blood vessel wall and prostate. Blocking of such receptors leads to causing widening (vasodilation) of the blood vessels along with lowering blood pressure levels; within men experiencing BPH, the medication blocks alpha-1 receptors resulting in relaxation of muscles inside the prostate and the bladder neck that contributes in easy flow of urines.
Cardura XL is taken once daily and should be swallowed whole with a full glass of water. The tablets should not be crushed, chewed, or split, as this can release the medication too quickly, which may increase the risk of side effects.
Here are some general instructions for using Cardura XL:
Take it with food: This may help reduce the risk of dizziness or lightheadedness, especially when starting the medication.
Stick to a regular schedule: Try to take Cardura XL at the same time each day to help remember.
Do not double up: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Never take two doses at once to make up for a missed one.
When alpha-1 receptors are blocked by Cardura XL, this causes the smooth muscles to relax, resulting in:
Dilatation of the blood vessels, which is helpful in reducing blood pressure in patients with hypertension.
Relaxation of the prostate and bladder neck muscles, which improves urine flow and alleviates symptoms in men with BPH.
Key benefits of the extended-release formulation:
Consistent medication levels: Cardura XL provides a steady release of the drug throughout the day, which helps maintain stable blood pressure and symptom control for BPH.
The ease of once-daily dosing: Since it is an extended-release formulation, Cardura XL need only be taken once in a day, which is more convenient than multiple doses of the immediate-release version.
Like any medication, Cardura XL can cause side effects. Some of the more common side effects include:
Dizziness or Lightheadedness: Especially when standing up quickly, due to a drop in blood pressure. This is more common when first starting the medication or increasing the dose.
Fatigue or Weakness: Some patients may experience tiredness or weakness, particularly during the initial stages of treatment.
Headaches: Headaches may occur as your body adjusts to the medication.
Swelling (Edema): Swelling in the hands, ankles, or feet may occur, especially in patients with pre-existing heart conditions.
Nausea: Some patients may experience stomach upset or nausea, especially when they first begin taking the medication.
Orthostatic Hypotension: A sudden drop in blood pressure when standing up, which may cause dizziness or fainting.
Palpitations: Some patients may experience a feeling of an irregular or rapid heartbeat, especially at higher doses.
Severe but rare side effects include allergic reactions, which can present with rash, itching, swelling of the face, lips, or throat, and difficulty breathing. Call for immediate medical attention if any of these severe reactions occur.
There are a number of important warnings and precautions to be taken when taking Cardura XL:
Low Blood Pressure:Cardura XL may lead to low blood pressure, even dizziness and faintness while standing. Therefore, do be very careful getting from a lying down or sitting position to prevent dizziness and faintness.
Liver and Kidney Disease: Patients with liver or kidney conditions require less or closer supervision due to the increased probability of Cardura XL to build-up to harmful levels in patients.
Pregnancy and Breastfeeding: Cardura XL is contraindicated in pregnancy due to its potential harmful effects on the fetus. Its excretion into breast milk is not known; hence, it is used with caution during breastfeeding.
Surgery: The patient must inform his healthcare provider and surgeon if he is undergoing surgery, as Cardura XL can interfere with the blood pressure of the patient during surgery.
Allergic Reactions: If you have a severe allergic reaction, which may include swelling of the face, lips, or throat, or difficulty breathing, seek medical attention immediately.
Cardura XL combines with several other medications so there is a need to closely monitor other possible interactions:
Other medications: Antihypertensives. If in combination with other drugs to help manage blood pressure, blood pressure may drop significantly leading to low blood pressure.
Medications for erectile dysfunction: Cardura XL should not be taken with drugs used to treat erectile dysfunction, such as sildenafil (Viagra), because a dangerous drop in blood pressure can occur.
Other alpha-blockers: The combination of Cardura XL with other alpha-blockers can cause low blood pressure and orthostatic hypotension (dizziness when rising).
Cimetidine: This drug may raise the blood levels of doxazosin, thereby increasing its effects and side effects.
CYP3A4 inhibitors: Drugs that inhibit the CYP3A4 enzyme, such as ketoconazole or ritonavir, may increase the levels of doxazosin, requiring careful monitoring and potential dose adjustments.
The treatment typically initiates using a dose of 4 mg once a day and may be changed based on the patient’s response to medication. The most common range for the maintenance dosage is from 4 mg to 8 mg a day, and the highest allowable dosage is 16 mg/day.
Patients must adhere strictly to their doctors’ detailed instructions on the prescription use of Cardura XL, taking as prescribed for better effects.
Cardura XL is a prescription medication, so it can only be obtained with a doctor’s prescription. If you are experiencing symptoms of BPH or have high blood pressure, consult your healthcare provider. They will assess your health condition and determine whether Cardura XL is the right treatment for you. Your doctor may adjust the dosage based on your response to treatment.
What is Cardura XL used for?
How does Cardura XL differ from regular Cardura?
What is the active ingredient in Cardura XL?
What is the typical starting dosage for Cardura XL?
Can I take Cardura XL with food?
What should I do if I miss a dose of Cardura XL?
What are the common side effects of Cardura XL?
Are serious side effects associated with Cardura XL?
Can Cardura XL cause weight gain?
Can I take Cardura XL with other medications?
Are there any dietary restrictions while taking Cardura XL?
Is Cardura XL safe for elderly patients?
Is Cardura XL safe to use during pregnancy?
Can I use Cardura XL long-term?
Will there be a need for dosage adjustment over time?
How often should I have my blood pressure checked while on Cardura XL?
What should I do if I experience dizziness or lightheadedness while taking Cardura XL?
What are some alternatives to Cardura XL for BPH or high blood pressure?
How does Cardura XL compare to other extended-release medications?
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