| Common Brands | Suprax |
|---|---|
|
Drug Class |
Cephalosporin antibiotic |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Cefixime is an expanded spectrum third-generation cephalosporin, related to the structure of penicillins, used as a broad spectrum antibiotic for combating bacterial infection through inhibition of bacterial development.
Although the third generations of cephalosporins resemble some earlier ones in possessing wide-ranging action against both Gram negative and positive organisms, cefixime seems to be the most sensitive one towards a wide array of Gram negative bacteria whereas still active in some gram positive bacteria as well. It is orally administered, which can make outpatient treatment more convenient as opposed to intravenous or intramuscular antibiotics.
Generally, cefixime comes in the form of a tablet or an oral suspension. Here is a general guide on using the medication:
Tablets: Cefixime tablets are administered orally, with or without food. It is usually taken once or twice a day, depending on the dose prescribed.
Suspension: The suspension should be shaken well before each use, and the right amount should be measured using a proper dosing spoon or syringe to ensure accurate dosing.
Dosage: Take the medicine according to the dosage schedule given by your healthcare provider. Do not take a higher or lower dose than the prescribed one, and finish the full course of treatment even if you feel better before the course is over.
Missed Dose: If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose—do not double the dose to make up for the missed one.
Cefixime is part of the beta-lactam antibiotic family of cephalosporins. It works as an antibiotic by interfering with the process of cell-wall formation in bacteria.
The cell wall is the structural framework needed for the survival of these bacteria. Cefixime acts by binding to and inhibiting the activity of penicillin-binding proteins, which are involved with the final stages of its cell-wall synthesis. After the inhibition of the mentioned process, the bacteria lose the structural integrity of their framework and eventually die.
Although cefixime is potent against both gram-negative and gram-positive bacteria, its action is stronger against gram-negative.
This is so because gram-negative organisms have a stronger dependency on the cell wall for their survival, while cefixime better penetrates their outer membrane.
Generally, cefixime is well-tolerated. However, there are several side effects some require medical attention. These most common side effects include :
Gastrointestinal effects: They are mainly nausea, vomiting, diarrhea, and abdominal pain. These are some of the most frequent side effects caused by cefixime.
Allergic reactions: They manifest as rash and itching. Rarely, anaphylaxis is a serious kind of allergic reaction.
Hepatic abnormalities: Patients may experience increases in levels of liver enzymes.
Haematological adverse effects: At times, there can be alterations in the blood count, which is decreased counts of white blood cells and platelets.
Kidney effects: In rare cases, cefixime can affect kidney function, particularly in patients with pre-existing kidney issues.
If you experience any signs of an allergic reaction (e.g., rash, swelling, difficulty breathing), or if you develop severe gastrointestinal symptoms, you should seek medical attention immediately.
Allergic reactions. Cefixime has to be administered with some caution in the patients of allergy due to cephalosporins or penicillins as cross-reactivity may occur.
Renal impairment. As cefixime exerts its action through renal excretion so patients suffering from renal dysfunction have to be monitored accordingly and their doses may vary.
Pregnancy and breastfeeding: Cefixime is generally considered safe during pregnancy (Category B), but it should only be used when necessary. It is excreted into breast milk in small amounts, so caution is advised when used by breastfeeding mothers.
Antibiotic resistance: Overuse or misuse of antibiotics can lead to the development of resistance. It is crucial to take cefixime exactly as prescribed and complete the full course of treatment.
Cefixime may interact with other drugs, which can either reduce its efficacy or enhance the risk of adverse effects:
Probenecid: This drug can inhibit the renal clearance of cefixime, thereby increasing its concentration in the blood and enhancing the risk of toxicity.
Antacids or proton pump inhibitors (PPIs): These medicines may decrease the absorption of cefixime in the stomach, thus making it ineffective.
Other antibiotics: Taking cefixime in combination with other antibiotics, especially those of similar mechanisms of action, may increase adverse effects or reduce the effect of either drug.
Always remind your doctor of all the drugs you are currently taking including over-the-counter medicines, supplements, and herbal medicine for this reason.
The usual dose of cefixime depends on the type and severity of the infection:
Adults: 200–400 mg per day, depending on the infection, usually given as one or two doses.
Children: The dosage is usually based on the child’s weight, ranging from 8 mg/kg per day, up to 400 mg per day, depending on the type of infection.
Dose adjustment may be required in patients with renal impairment.
Cefixime is a prescription medication and should be applied under the supervision of a physician. A doctor will determine what type of infection and to what extent it is needed before prescribing cefixime; otherwise, the patient should observe closely his dosing schedule so that his infection will be treated correctly.
What is Cefixime used for?
How is Cefixime administered?
What is the usual dosage of Cefixime for adults?
Can children use Cefixime?
What are the common side effects of Cefixime?
Are there any serious side effects associated with Cefixime?
Can Cefixime be used in patients with kidney problems?
Is Cefixime safe during pregnancy?
Can Cefixime interact with other medications?
What should I do if I miss a dose of Cefixime?
How long is Cefixime typically prescribed?
Can Cefixime be used to treat viral infections?
Are there any dietary restrictions while taking Cefixime?
Is it important to complete the full course of Cefixime?
What should I do if I experience an allergic reaction to Cefixime?
How should Cefixime be stored?
Will Cefixime affect my lab test results?
Can I drink alcohol while taking Cefixime?
What happens if Cefixime does not work for my infection?
Where can I find more information about Cefixime?
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