| Common Brands | Evoxac |
|---|---|
|
Drug Class |
Cholinergic agonist |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Cevimeline is a cholinergic agonist that specifically targets the muscarinic receptors in the salivary glands. By stimulating these receptors, Cevimeline promotes the secretion of saliva. It is particularly beneficial for patients with Sjogren’s syndrome, a condition characterized by dry mouth and dry eyes due to the body’s immune system attacking its own glands. The medication works by activating the M3 muscarinic receptors, which are primarily involved in the production of saliva, as well as other secretions from exocrine glands.
Cevimeline can also be used in the treatment of dry mouth caused by other conditions, such as radiation therapy for head and neck cancers, which can damage the salivary glands and lead to reduced saliva production.
Cevimeline is available in oral capsule form and should be taken by mouth. The medication should be taken as directed by your healthcare provider, typically 30 mg three times a day.
Cevimeline acts by stimulating the M3 muscarinic receptors located in the salivary glands. Muscarinic receptors are part of the body’s parasympathetic nervous system, which controls various involuntary functions, including the production of saliva, sweat, and gastric juices.
When Cevimeline binds to these receptors, it activates them, leading to an increase in the production of saliva. This is particularly beneficial for individuals suffering from dry mouth caused by conditions such as Sjogren’s syndrome, where the immune system attacks the salivary glands, leading to reduced saliva output.
By stimulating the parasympathetic nervous system, Cevimeline helps to restore a more normal level of salivation, providing relief from the symptoms of dry mouth. Additionally, the increased saliva production can improve oral comfort, assist in swallowing, and promote better oral hygiene by reducing the risk of tooth decay and gum disease, which are common in individuals with dry mouth.
Common side effects of Cevimeline include:
More severe side effects are rare but may include:
If you experience any severe side effects, you should contact your healthcare provider immediately.
Cevimeline may interact with several medications, including:
As with any medication, it is crucial to inform your healthcare provider about all other drugs you are taking, including prescription and over-the-counter medications, as well as any herbal supplements.
The typical dosage of Cevimeline is 30 mg, taken orally three times a day. The medication is usually taken with or without food. The dosage may be adjusted based on the individual’s response to the drug and the severity of their symptoms. It is important for patients to follow the prescribing physician’s instructions and take the medication regularly to achieve the best results.
For patients with renal impairment or liver disease, the dosage of Cevimeline may need to be adjusted. In some cases, lower doses or longer intervals between doses may be recommended to minimize the risk of adverse effects.
Cevimeline is a prescription-only medication and should be prescribed by a healthcare provider. It is essential for patients to discuss their medical history, including any pre-existing conditions such as glaucoma, asthma, or heart disease, before starting treatment with Cevimeline.
Cevimeline is primarily used to treat symptoms of dry mouth caused by conditions like Sjögren’s syndrome.
It stimulates the salivary glands to increase saliva production by activating muscarinic receptors.
Patients with dry mouth due to Sjögren’s syndrome or other similar conditions, as prescribed by a doctor.
Typically, Cevimeline is taken orally three times a day with meals, following a healthcare provider’s instructions.
The usual starting dose is 30 mg three times daily; dosage may be adjusted based on response and tolerance.
You might notice improvement in dry mouth symptoms within a few weeks of starting treatment.
Common side effects include sweating, nausea, runny nose, and increased urination.
Though rare, some people may experience allergic reactions like rash, itching, or swelling and should seek immediate medical attention.
Consult your doctor before use, as the safety during pregnancy hasn’t been conclusively established.
Cevimeline is generally prescribed for adults; pediatric use should be under strict medical supervision if at all.
Avoid alcohol and medications that may worsen dry mouth or interact adversely; always check with your doctor.
Inform your doctor about all medications to avoid interactions, especially with cholinergic agents or beta-blockers.
Take the missed dose as soon as you remember unless it’s almost time for the next dose; do not double up.
Yes, overdose can cause severe side effects like difficulty breathing, severe nausea, or muscle weakness; seek emergency help.
Store at room temperature away from moisture, heat, and direct light.
Its main approved use is dry mouth relief; any other uses should only be under medical advice.
No, it requires a prescription from a healthcare provider.
Long-term use is common under supervision; your doctor will monitor for effectiveness and side effects.
Yes, staying hydrated and avoiding caffeine, alcohol, and tobacco may improve dry mouth symptoms alongside medication.
Contact your healthcare provider to reassess your treatment and discuss alternative options.
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