Administration:

• • Deucravacitinib is taken as a tablet, once a day.
  • It can be taken with or without food, making it convenient for those with busy schedules.
  • Swallow the tablet whole; do not chew or crush it.
  • If you miss a dose, take it as soon as you remember, but if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for the missed dose.

Storage:

• Store Deucravacitinib at room temperature, away from excessive heat, moisture, and light. Keep it in a tightly closed container out of reach of children.

Deucravacitinib works by inhibiting TYK2, which is involved in the signaling of several important cytokines (proteins that regulate immune and inflammatory responses). These cytokines are associated with the activation of the immune system, and their uncontrolled activity leads to the development of inflammatory diseases like psoriasis.

By blocking the TYK2 enzyme, Deucravacitinib prevents the downstream signaling of pro-inflammatory cytokines such as IL-12, IL-23, and IL-6, which are involved in immune system activation. This results in a reduced immune response and helps to control the skin inflammation that causes the characteristic plaques in psoriasis.

Unlike other traditional treatments for psoriasis, Deucravacitinib specifically targets the root cause of the disease, leading to improved symptoms with potentially fewer side effects compared to older therapies.

• Common Side Effects:
  • Headache: Some individuals may experience mild to moderate headaches.
  • Diarrhea: Gastrointestinal side effects like diarrhea are not uncommon when taking Deucravacitinib.
  • Upper respiratory infections: Deucravacitinib may increase the risk of common infections like the cold or flu due to its effect on the immune system.
  • Nausea: Some users might feel nauseous, especially when first starting the medication.
  • Fatigue: Feeling tired or fatigued can occur, especially in the initial phase of treatment.
• Serious Side Effects:
  • Infections: As Deucravacitinib suppresses the immune system, it may make you more susceptible to serious infections, including tuberculosis, fungal infections, and bacterial infections. If you develop signs of infection, such as fever, chills, or persistent cough, contact your doctor immediately.
  • Liver issues: Some patients may experience liver problems. Symptoms like yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain should be reported to your doctor immediately.
  • Blood clots: Rarely, Deucravacitinib may increase the risk of blood clots, leading to symptoms like swelling, pain, or redness in the limbs. If you notice these symptoms, seek medical help right away.

• Immune System Suppression: Deucravacitinib can lower the body’s ability to fight infections, so it is important to avoid exposure to people with contagious illnesses and practice good hygiene.
• Live Vaccines: Because of the immunosuppressive effects, live vaccines should be avoided while using Deucravacitinib.
• Liver and Kidney Function: Those with pre-existing liver or kidney issues should use Deucravacitinib with caution. Dose adjustments may be required, and regular monitoring is essential.
• Pregnancy and Breastfeeding: Deucravacitinib has not been studied extensively in pregnant or breastfeeding women. It should only be used if the potential benefits outweigh the risks. Always consult your doctor before using any medication during pregnancy or breastfeeding.

• CYP450 Enzyme Inhibitors (e.g., ketoconazole, itraconazole): These medications may increase the concentration of Deucravacitinib in the body, potentially leading to side effects. Your healthcare provider may adjust your dose or monitor you more closely if these drugs are used together.
• CYP450 Enzyme Inducers (e.g., rifampin, carbamazepine): These can decrease the effectiveness of Deucravacitinib, and dosage adjustments might be needed if such medications are prescribed together.
• Live vaccines: Since Deucravacitinib suppresses the immune system, it may interfere with the effectiveness of live vaccines. Avoid getting live vaccines during treatment unless advised otherwise by a healthcare provider.
• Immunosuppressive medications: Caution should be used when Deucravacitinib is taken alongside other immunosuppressive drugs, as this can further increase the risk of infections.

• Starting Dose: The typical starting dose is 10 mg once daily.
• Liver/Kidney Impairment: For individuals with liver or kidney issues, a lower dose of 5 mg daily may be recommended.
• Adjustments: Your healthcare provider will monitor your response to the medication and adjust the dose accordingly to ensure maximum benefit while minimizing potential side effects.

Deucravacitinib is a prescription-only medication, and it should be used under the supervision of a healthcare provider. It is important to have regular check-ups to monitor for potential side effects, especially related to the immune system and liver function.

1. What is Deucravacitinib used for?

   • It is used for treating moderate to severe plaque psoriasis.

2. What is the brand name of Deucravacitinib?

   • Sotyktu.

3. How does Deucravacitinib work?

   • It is a selective TYK2 (tyrosine kinase 2) inhibitor that modulates the immune response.

4. Is Deucravacitinib an oral medication?

   • Yes, it is taken orally in pill form.

5. How long does Deucravacitinib take to show effects?

   • Improvement can be seen within weeks to months of treatment.

6. What are common side effects of Deucravacitinib?

   • Upper respiratory infections, headache, fatigue.

7. Is Deucravacitinib safe for long-term use?

   • Safety data is still being evaluated; use under medical supervision is important.

8. Can Deucravacitinib be used for other conditions?

   • Currently approved for psoriasis; research ongoing for other autoimmune diseases.

9. Is Deucravacitinib immunosuppressive?

   • Yes, it modulates the immune system by inhibiting TYK2.

10. Does Deucravacitinib require refrigeration?

    • No, it can be stored at room temperature.

11. Can patients take Deucravacitinib with other psoriasis treatments?

    • Use with other immunosuppressive drugs should be under doctor guidance.

12. Are there any serious side effects of Deucravacitinib?

    • Potential serious infections, allergic reactions.

13. Is Deucravacitinib safe during pregnancy?

    • Safety in pregnancy is not established; consult your healthcare provider.

14. Can Deucravacitinib affect vaccination efficacy?

    • It may alter immune response; consult doctor for vaccination timing.

15. How often should Deucravacitinib be taken?

    • Usually once daily, as prescribed.

16. Can Deucravacitinib cause liver problems?

    • Liver function should be monitored during use.

17. Does Deucravacitinib cause weight gain?

    • Weight gain is not commonly reported.

18. Is Deucravacitinib available in generic form?

    • No, it is currently available only as brand name Sotyktu.

19. Is Deucravacitinib a controlled substance?

    • No, it is not controlled.

20. How should Deucravacitinib be stored?

    • Stored at room temperature, away from moisture and heat.