Dextromethorphan, guaifenesin, and phenylephrine

Common Brands Mucinex Fast-Max, Robitussin Multi-Symptom, various generics
Drug Class
Cough suppressant (Dextromethorphan), Expectorant (Guaifenesin), Nasal decongestant (Phenylephrine)
Controlled Substance Classification
Not a controlled medication
Generic Status
Lower-cost generic available
Availability
Over-the-counter
Robert Chad Hakim, PharmD, BCCCP
Robert Chad Hakim, PharmD, BCCCP
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Medically reviewed by Robert Chad Hakim, PharmD, BCCCP last update on 20/12/2023

Overview

Dextromethorphan, guaifenesin, and phenylephrine are often combined in over-the-counter (OTC) medications to treat a variety of symptoms related to colds, flu, and respiratory issues. This combination targets different aspects of discomfort, providing relief from symptoms such as cough, congestion, and mucus buildup.

  • Dextromethorphan is a cough suppressant that works by reducing the urge to cough, especially for dry, non-productive coughs.
  • Guaifenesin is an expectorant that helps loosen mucus in the airways, making it easier to cough up and clear out. It is particularly useful for productive (wet) coughs.
  • Phenylephrine is a decongestant that works by constricting blood vessels in the nasal passages, thereby reducing swelling and allowing the nasal passages to open, which makes breathing easier.

By combining these three ingredients, the medication can relieve multiple symptoms associated with respiratory conditions like colds, allergies, or sinus infections, helping to make breathing easier and reducing the discomfort caused by coughing and congestion.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

Pregnancy

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