Dutasteride is administered in capsule form, once a day. Here’s how to use it correctly:
- Take as instructed: Make sure to take your healthcare provider’s instructions on the frequency and amount.
- Swallow whole: Do not crush or chew the capsule. Swallow the whole capsule with a full glass of water.
- Be patient: Dutasteride can have a delayed effect. It can take 3 to 6 months to see some improvement in BPH symptoms or hair growth.
- Consistency: Take the medicine at the same time every day to help the memory.
Dutasteride blocks the activity of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). DHT is a hormone that plays a role in both prostate gland enlargement and male pattern baldness.
- Prostate Health: The prostate gland enlargement in BPH is caused by excess DHT. Reduced levels of DHT induce shrinkage of the prostate, which may alleviate symptoms such as painful urination, frequent urination, and urgency.
- Hair Growth: DHT is also the major offender in baldness in men, leading to balding of hair on the scalp. By limiting the production of DHT, dutasteride averts miniaturization of the hair follicles, leading to the regrowth of hair and halting further hair loss.
Just like any prescribed medication, dutasteride does have side effects, but they are not what anybody would anticipate. Some of the most common and hazardous side effects are:
Common Side Effects:
- Loss of sex drive (libido)
- Difficulty in attaining or maintaining an erection (erectile dysfunction)
- Loss of volume of semen
- Breast tenderness or swelling
- Dizziness or faintness
Severe Side Effects
- Allergic Reactions: Rash, itching, or swelling (especially face, tongue, or throat) are symptoms of an allergic reaction.
- Breast Cancer: Although unusual, some occurrences of male breast cancer have been reported in dutasteride-treated patients. Report any breast change, including tenderness or lump, to your doctor immediately.
- Severe Mood Changes: In rare instances, dutasteride can cause depression or mood changes. If you find that you are becoming very sad or hopeless, you should get help.
Before dutasteride is taken, there are some important warnings and precautions:
- Pregnancy: Dutasteride should not be taken by pregnant women or female patients who may become pregnant because the medication may damage a male fetus being formed during pregnancy. Women should not handle crushed or broken capsules.
- Liver Disease: For patients with liver disease, your doctor can monitor liver function while you are taking dutasteride because the medication is metabolized in the liver.
- Prostate Cancer: Dutasteride may postpone the detection of prostate cancer by lowering PSA (prostate-specific antigen) levels. If you have prostate cancer or are being diagnosed with prostate cancer, tell your doctor about it before the use of the drug.
- Men with Infertility: Dutasteride affects sperm count and motility in some men. If you are planning to become pregnant, discuss it with your doctor.
Dutasteride may interact with other medication. Some of the most common interactions are:
- Alpha-blockers: Medications used for BPH or high blood pressure (such as tamsulosin). Simultaneous use of these with dutasteride may lead to a higher risk of dizziness or low blood pressure.
- Other 5-alpha-reductase inhibitors: Other 5-alpha-reductase inhibitor medications (such as finasteride) should be avoided unless on medical advice.
- Precautions during Handling: Pregnant women or women who are capable of getting pregnant must not handle the capsules since exposure to the drug by the drug touching their skin may damage a developing male fetus. Dutasteride is absorbed by the body through the skin.
The recommended dose of dutasteride in BPH is 0.5 mg per day. In case it is baldness in males, then the dosage may be the same but the effect may take weeks to be noticed.
Dutasteride needs to be administered daily and one needs to follow the regime provided by the health care physician.
Dutasteride is a prescription medication. This implies that it can only be taken on prescription from a doctor, who will assess your situation and determine if dutasteride is suitable for you.
Regular follow-up visits will be necessary to check on how your treatment is progressing and how any side effects are being controlled.