| Common Brands | Feiba VH Immuno |
|---|---|
|
Drug Class |
Activated Prothrombin Complex Concentrate (aPCC) |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only (specialty infusion therapy) |
Feiba VH Immuno is a special medicine used to treat people with hemophilia A and hemophilia B who have inhibitors (antibodies that block regular treatments like factor VIII or IX). When normal clotting factor medicines don’t work because of these inhibitors, Feiba VH Immuno can help stop or prevent bleeding.
This medicine is a bypass agent, meaning it helps the blood to clot even when certain clotting factors are missing or blocked. It is made from plasma proteins and is given as an injection into a vein (IV).
Feiba VH Immuno is also used before surgeries or dental work in hemophilia patients with inhibitors to prevent serious bleeding. The “VH” stands for Vapor Heat, a method used to make the medicine safe from viruses during production.
Feiba VH Immuno is available as a powder that must be mixed with sterile water before injection.
Only trained people (nurses, doctors, or trained caregivers) should prepare and give Feiba VH Immuno. If you are using it at home, follow the doctor’s instructions carefully.
Normally, the body uses clotting factors to stop bleeding. In hemophilia, people lack these factors—especially factor VIII (in hemophilia A) or factor IX (in hemophilia B). Some patients also develop inhibitors—antibodies that stop the replacement clotting factors from working.
Feiba VH Immuno works by bypassing the blocked pathway. It contains a mix of activated and non-activated clotting factors, including:
These help the blood form a strong clot without needing factor VIII or IX, which may not work in patients with inhibitors.
This helps to:
Reduce bleeding risk in patients with antibodies
Feiba VH Immuno, like all medicines, can cause side effects. Some are mild, but others can be serious.
Always tell your doctor about any side effects. If you experience chest pain, difficulty breathing, or signs of a blood clot (like swelling in the leg or sudden numbness), get medical help immediately.
Feiba VH Immuno must be used with caution, especially in patients at risk for clotting problems.
Patients should be monitored closely for any signs of clotting or allergic reactions.
Always tell your doctor about any other medicines, supplements, or herbal products you are using.
Feiba VH Immuno is measured in units based on clotting activity. The dose will depend on the patient’s weight and bleeding condition.
Do not change the dose without your doctor’s advice. Taking too much increases the risk of dangerous clots.
Always follow your doctor’s instructions, and store the medicine properly in a cool place.
Feiba VH Immuno is a prescription-only medicine. It cannot be bought without a doctor’s order. It is usually prescribed by a hematologist, a doctor who treats bleeding disorders like hemophilia.
Before prescribing Feiba VH Immuno, the doctor will:
Feiba VH Immuno may be available from specialty pharmacies or hospital supply systems, and often comes with support programs to help patients with home use and safety.
What is Feiba VH Immuno used for?
It is used to treat and prevent bleeding episodes in patients with hemophilia A or B who have developed inhibitors (antibodies) against clotting factors VIII or IX.
It is also used for surgical bleeding control and routine prophylaxis in these patients.
What does “VH Immuno” stand for?
“VH” refers to virus inactivated and heat-treated, and Immuno denotes the manufacturer (Baxter/Immuno).
This ensures the product’s safety and viral inactivation during production.
What is the active component of Feiba VH Immuno?
It is an Activated Prothrombin Complex Concentrate (aPCC) containing:
Activated Factor VII (VIIa)
Non-activated Factors II, IX, and X
How does Feiba VH Immuno work?
It helps the blood bypass the missing or inhibited factor VIII or IX, promoting the formation of a stable blood clot even when inhibitors are present.
How is Feiba VH Immuno given?
By intravenous (IV) infusion, administered by a healthcare professional or a trained patient/caregiver.
What are the typical indications for Feiba VH Immuno?
On-demand control of bleeding
Perioperative management of bleeding during surgery
Routine prophylaxis to prevent bleeds in inhibitor patients
What are the common side effects?
Headache, fever, nausea, chills, or injection site discomfort.
Are there serious side effects?
Yes, though rare. Serious risks include:
Thrombosis (blood clots) — stroke, heart attack, deep vein thrombosis
Disseminated Intravascular Coagulation (DIC)
Allergic or anaphylactic reactions
Inhibitor formation against additional clotting factors
Who should not receive Feiba VH Immuno?
Patients with disseminated intravascular coagulation (DIC)
Those with known hypersensitivity to human plasma proteins
Why is Feiba VH Immuno preferred for patients with inhibitors?
Because it contains activated factors that bypass the blocked factor pathway, enabling clot formation even when the immune system neutralizes factor VIII or IX replacement.
How fast does it work?
Bleeding control usually begins within minutes to hours of administration.
How often is Feiba VH Immuno given?
Dosing depends on the type and severity of bleeding — often every 6 to 12 hours for active bleeds, or a few times weekly for prophylaxis.
Is Feiba VH Immuno used for children?
Yes, it is approved for pediatric use under close medical supervision.
Is Feiba VH Immuno made from human plasma?
Yes, it is derived from pooled human plasma, but undergoes multiple viral inactivation processes (solvent/detergent and dry heat) for safety.
Can Feiba VH Immuno be used during pregnancy?
Only if clearly needed — its safety in pregnancy has not been fully established.
Can it be used while breastfeeding?
Use with caution; it’s unknown if it passes into breast milk.
Does Feiba VH Immuno interact with other medicines?
Avoid concurrent use with recombinant factor VIIa (NovoSeven) unless under strict medical supervision, due to increased thrombotic risk.
How should Feiba VH Immuno be stored?
Store at room temperature (2°C–25°C / 36°F–77°F).
Once reconstituted, use within 3 hours; do not refrigerate after mixing.
Is there a generic or biosimilar available?
No — Feiba VH Immuno remains brand-only.
Where can I get Feiba VH Immuno?
Available by prescription through specialty pharmacies and hemophilia treatment centers.
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