| Common Brands | Feiba VH |
|---|---|
|
Drug Class |
Activated Prothrombin Complex Concentrate (aPCC) |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only (infusion therapy) |
Feiba is a clotting medicine used to help people with bleeding disorders, especially hemophilia A and hemophilia B. These are conditions where the blood does not clot properly, which can lead to serious bleeding from even small injuries.
Feiba is mainly used in patients who have inhibitors (antibodies) that block the usual treatments like factor VIII or IX. In these cases, regular clotting factor medicines don’t work, so Feiba is used instead.
Feiba stands for:
Factor
Eight
Inhibitor
Bypass
Activity
Feiba is given as an injection into a vein (IV) and must be used under a doctor’s care, often in hospitals or clinics, but sometimes at home if trained.
Feiba is given as an intravenous (IV) infusion, which means it is injected slowly into a vein. It can be given:
Instructions for use:
Feiba should not be mixed with other medicines in the same syringe.
In normal blood clotting, certain clotting factors work together to stop bleeding. People with hemophilia don’t have enough of these factors, especially factor VIII (in hemophilia A) or factor IX (in hemophilia B).
Some people develop inhibitors, which are antibodies that block the treatment (factor replacement therapy). This makes it harder to stop bleeding.
Feiba bypasses the blocked steps in the clotting process. It contains a mix of activated and non-activated clotting factors (mainly factors II, VII, IX, and X). These help the blood to clot even if inhibitors are present.
Feiba helps to:
Lower the risk of spontaneous bleeds
Like all medicines, Feiba can cause side effects, ranging from mild to serious. Most people use it safely, but some may experience the following:
Common side effects:
Serious side effects:
Call your doctor immediately if you notice symptoms like chest pain, breathing trouble, weakness in one side of the body, or unusual bleeding.
Feiba is very powerful, so it must be used carefully:
Doctors may do blood tests to check clotting and ensure the medicine is working safely.
Always tell your doctor about all the medicines, vitamins, or supplements you are taking before using Feiba.
Feiba dosage is based on units per kilogram (kg) of body weight. Each vial is labeled with how many units it contains.
Typical dosage ranges:
Feiba should not be used too frequently or in high doses unless absolutely necessary due to clotting risks. Always follow your doctor’s exact instructions.
Feiba is a prescription-only medicine. It cannot be bought over the counter. It must be prescribed by a specialist, such as a hematologist, who treats bleeding disorders.
Before prescribing Feiba, your doctor will:
Feiba is usually kept in hospitals and specialty pharmacies that manage rare and complex conditions. It may also be provided through home infusion services.
What is Feiba used for?
It is used to help control or prevent bleeding episodes in people with hemophilia A or B who have developed inhibitors (antibodies) against standard clotting factor therapies.
It is also used for perioperative (surgical) management in such patients.
What is the full name of Feiba?
Feiba VH (Factor Eight Inhibitor Bypassing Activity).
What does Feiba contain?
It is an activated prothrombin complex concentrate (aPCC) that contains:
Activated and non-activated clotting factors (II, IX, X, and activated VII).
How does Feiba work?
It helps the blood bypass the missing or inhibited factor VIII or IX to form a stable clot, controlling bleeding even when inhibitors are present.
How is Feiba administered?
By intravenous (IV) infusion, given by a healthcare professional or trained patient/caregiver.
What are the typical uses?
On-demand treatment of bleeding episodes
Routine prophylaxis to reduce bleed frequency
Before or during surgery to prevent excessive bleeding
How often is Feiba given?
Dosing frequency depends on the severity of bleeding and clinical need — often every 6 to 12 hours for acute bleeds or a few times per week for prophylaxis.
What are the common side effects?
Headache, nausea, mild fever, dizziness, or injection site reactions.
Are there serious side effects?
Yes — rare but serious risks include:
Thromboembolic events (blood clots) such as deep vein thrombosis or stroke
Allergic/anaphylactic reactions
Disseminated intravascular coagulation (DIC)
Who should not use Feiba?
Patients with disseminated intravascular coagulation (active clotting disorder)
Those with known hypersensitivity to any Feiba components (e.g., human plasma proteins)
Can Feiba be used with other clotting agents?
Caution is required — do not use Feiba with recombinant factor VIIa (NovoSeven) unless under strict medical supervision due to clotting risk.
Do patients need monitoring during therapy?
Yes — monitoring includes clinical evaluation, thrombotic risk assessment, and coagulation parameters (though standard clotting tests may not fully reflect activity).
How quickly does Feiba work?
Bleeding control often begins within minutes to hours after infusion.
Can Feiba be used for prophylaxis (prevention)?
Yes — regular prophylactic infusions have been shown to reduce bleeding frequency in inhibitor patients.
Is Feiba safe for children?
Yes, it is approved for pediatric use under specialist supervision.
Is Feiba safe during pregnancy?
Use only if clearly needed — limited human data are available.
Can I take Feiba while breastfeeding?
It’s unknown whether it passes into breast milk — consult a healthcare provider before use.
How should Feiba be stored?
Store at room temperature or in the refrigerator (2°C–25°C / 36°F–77°F). Do not freeze. Once reconstituted, use within 3 hours.
Is Feiba made from human plasma?
Yes, it is plasma-derived, but it undergoes viral inactivation and purification steps to ensure safety.
Is there a generic version?
No — Feiba is available as brand only.
Where can I get Feiba?
Available by prescription through specialty pharmacies or hemophilia treatment centers.
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