FIRST-Progesterone VGS 100 is a vaginal suppository, which means it must be inserted into the vagina.

Steps to Use:

1. Wash your hands with soap and water.

    

2. Lie on your back with knees bent or stand with one leg raised.

    

3. Gently insert the suppository deep into the vagina, using your finger or an applicator (if provided).

    

4. Wash your hands again.

    

5. Stay lying down for a few minutes to help the medicine absorb.

    

Use the medicine at the same time every day, and do not miss doses. If you forget a dose, take it as soon as possible—unless it’s almost time for the next one.

Avoid using tampons, douches, or other vaginal products unless your doctor says it’s okay.

Progesterone is a hormone made by a woman’s body after ovulation (release of an egg). It prepares the lining of the uterus (womb) to accept and support a fertilized egg.

If progesterone levels are too low, the uterus lining may not be ready, and this can cause problems like:

• Difficulty getting pregnant

   

• Miscarriage

   

• Irregular periods

   

FIRST-Progesterone VGS 100 works by giving your body the extra progesterone it needs. It supports the uterus and helps keep the pregnancy safe, especially in women going through IVF or fertility treatments.

Because this medicine is placed inside the vagina, it goes directly to the uterus, which makes it work more effectively.

Most women use FIRST-Progesterone VGS 100 without major problems. But like all medicines, it can cause some side effects.

Common Side Effects:

• Vaginal discharge

   

• Breast tenderness

   

• Headache

   

• Mood changes (irritability or sadness)

   

• Bloating

   

• Tiredness or dizziness

   

Serious Side Effects (rare):

• Blood clots (pain in the leg, chest pain, trouble breathing)

   

• Depression or severe mood swings

   

• Allergic reaction (swelling, rash, itching)

   

• Vaginal irritation or burning

   

Call your doctor right away if you have any unusual symptoms, especially chest pain, swelling, or heavy bleeding.

Before using FIRST-Progesterone VGS 100, tell your doctor if you:

• Have a history of blood clots or stroke

   

• Have liver disease

   

• Have breast cancer or other hormone-sensitive cancers

   

• Are allergic to progesterone or peanut oil (used in some formulations)

   

• Are pregnant or breastfeeding (your doctor will guide you depending on your case)

   

Important Warnings:

• Progesterone can increase the risk of blood clots, especially in smokers or women over 35.

   

• Do not use with other vaginal medicines at the same time unless advised.

   

• Talk to your doctor if you have abnormal vaginal bleeding or unexplained abdominal pain.

   

Regular check-ups and blood hormone tests may be needed to track your progress.

Progesterone can interact with some other medicines, such as:

• Other hormone treatments

   

• Vaginal creams or gels

   

• Certain herbal supplements

   

• Some medications that affect liver enzymes

   

Tell your doctor about all medicines you are using, including herbal or natural products.

Your doctor will decide the right dose and timing based on your condition.

For IVF or fertility support:

• Usually 100 mg to 200 mg per day

   

• Start after egg retrieval or embryo transfer

   

• Continue until 10–12 weeks of pregnancy or as directed

   

For hormone therapy or period regulation:

• May be used for 10–14 days per month

   

• Often combined with estrogen therapy in postmenopausal women

   

General Guidelines:

• Use at the same time every day

   

• Do not skip or stop without asking your doctor

   

• If you miss a dose, take it as soon as possible. Skip it if it’s almost time for the next dose.

   

Proper timing is very important for this medicine to work correctly, especially in fertility treatments.

FIRST-Progesterone VGS 100 is a prescription-only medicine, which means:

• It must be prescribed by a licensed doctor

   

• Often used under fertility specialists’ care

   

• Not available over the counter

   

• Must be stored properly—room temperature, away from heat and moisture

   

Doctors may require blood tests or ultrasounds to check how your body is responding to the treatment.

In many countries, this medicine is covered by insurance if used for medical fertility support. Ask your healthcare provider about cost assistance programs if needed.

• What is FIRST-Progesterone VGS 100 used for?
  It is used to supplement or replace natural progesterone in women who are deficient in the hormone.
  Common uses include:

  • Supporting pregnancy (especially after fertility treatments like IVF).

  • Treating secondary amenorrhea (absence of menstrual periods).

  • Balancing hormones in women with luteal phase defects.

• What is the brand name?
  FIRST-Progesterone VGS 100® (by CutisPharma).

• What is the active ingredient?
  Progesterone USP, micronized — a bioidentical hormone chemically identical to natural human progesterone.

• How does FIRST-Progesterone VGS 100 work?

  • Progesterone prepares the uterine lining (endometrium) for implantation of a fertilized egg.

  • Maintains early pregnancy by supporting the uterine environment.

  • Helps regulate menstrual cycles and prevent estrogen dominance.

• What type of medication is it?
  A vaginal progesterone suppository (hormone replacement therapy).

• How is FIRST-Progesterone VGS 100 administered?

  • Insert one vaginal suppository (100 mg) deep into the vagina once or twice daily, as prescribed.

  • Best inserted while lying down (usually at bedtime).

  • Wash hands before and after use.

• What are the available strengths and forms?

  • 100 mg vaginal suppositories (in ready-to-dispense pharmacy kits).

  • Also available in 200 mg and 400 mg strengths under similar FIRST-Progesterone labels.

• How long does it take to work?

  • Hormonal and uterine effects begin within a few days of use.

  • In fertility protocols, effectiveness is monitored through progesterone blood levels and pregnancy progress.

• What are the common side effects?

  • Vaginal discharge or irritation

  • Breast tenderness

  • Fatigue or dizziness

  • Mild headache

  • Abdominal bloating

• Are there serious side effects?
  Rare, but possible:

  • Severe allergic reaction (rash, itching, swelling)

  • Depression or mood changes

  • Blood clots (leg pain, chest pain, shortness of breath) — especially in high-risk patients

  • Severe headache or vision changes

• Who should not use FIRST-Progesterone VGS 100?

  • Women with known or suspected breast or uterine cancer

  • Undiagnosed vaginal bleeding

  • History of blood clots, stroke, or liver disease

  • Allergy to progesterone or product ingredients

• Can it be used during pregnancy?
  Yes — it is commonly prescribed during early pregnancy to support implantation and prevent miscarriage in women with progesterone deficiency.

• Can it be used while breastfeeding?
  Use with caution — small amounts may pass into breast milk, but generally considered safe under medical supervision.

• Does FIRST-Progesterone VGS 100 interact with other medications?

  • No major drug interactions, but avoid other vaginal products (creams, douches) at the same time, as they can affect absorption.

  • Always inform your doctor if using other hormone therapies.

• Can it cause drowsiness or dizziness?
  Yes — progesterone may cause mild sedation in some users. Best taken at bedtime.

• How should I store FIRST-Progesterone VGS 100?

  • Store at controlled room temperature (20 °C–25 °C / 68 °F–77 °F).

  • Keep away from direct heat or sunlight.

  • Do not freeze.

• Is there a generic available?

  • Progesterone suppositories are available generically, but FIRST-Progesterone VGS 100® is a brand-compounded pharmacy formulation (CutisPharma’s FIRST line).

• Where can I get it?
  Available by prescription only, dispensed through pharmacies that provide the FIRST-compounded hormone kits.