FIRST-Progesterone VGS 200 is a vaginal suppository, which means it must be placed inside the vagina to work.

Instructions:

1. Wash your hands.
   
   
2. Lie down with knees bent, or stand with one leg raised.
   
   
3. Gently insert the suppository deep into the vagina, using a finger or applicator if provided.
   
   
4. Wash your hands again.
   
   
5. Remain lying down for a few minutes to help absorption.
   
   

Use the medicine at the same time every day. If your doctor prescribes it twice a day, try to space the doses evenly.

FIRST-Progesterone VGS 200 contains micronized progesterone, which is similar to the natural hormone made in a woman’s body after ovulation.

Progesterone helps the uterus lining (endometrium) become thick and healthy, so it can support a fertilized egg. This is very important for:

• Successful implantation
  
  
• Supporting early stages of pregnancy
  
  
• Preventing miscarriages due to low hormone levels
  
  

In women who do not make enough natural progesterone, this medicine replaces or boosts the hormone level and helps maintain a normal cycle or pregnancy.

Because it is placed directly in the vagina, it works closely near the uterus and has fewer overall side effects compared to oral forms.

Most women tolerate this medicine well. But, like all medications, it can cause some side effects.

Common Side Effects:

• Vaginal discharge
  
  
• Headache
  
  
• Bloating
  
  
• Breast tenderness
  
  
• Mood swings
  
  
• Drowsiness or dizziness
  
  

Less Common But Serious Side Effects:

• Blood clots (leg pain, chest pain, difficulty breathing)
  
  
• Severe allergic reactions (rash, swelling, itching)
  
  
• Depression or mood changes
  
  
• Vaginal irritation or burning sensation
  
  
• Unusual vaginal bleeding
  
  

Call your doctor right away if you notice heavy bleeding, shortness of breath, or other serious symptoms.

Before using FIRST-Progesterone VGS 200, tell your doctor if you:

• Have a history of blood clots, stroke, or heart disease
  
  
• Have liver problems
  
  
• Have breast cancer or other hormone-related cancer
  
  
• Have abnormal vaginal bleeding
  
  
• Are pregnant, planning pregnancy, or breastfeeding
  
  
• Are allergic to progesterone or peanut oil (used in some progesterone products)
  
  

Warnings:

• Do not use if you are allergic to progesterone or any of the ingredients.
  
  
• Avoid if you’ve had serious clotting problems unless your doctor says it’s okay.
  
  
• Avoid alcohol and smoking—they increase the risk of hormone side effects.
  
  
• Always follow dosage instructions carefully.
  
  
• Let your doctor know if you have mental health concerns like depression.
  
  

Regular check-ups and blood tests may be needed to monitor hormone levels and pregnancy progress.

Tell your doctor if you are taking:

• Other hormonal medicines
  
  
• Vaginal creams or antifungal treatments
  
  
• Herbal products like St. John’s Wort
  
  
• Medicines that affect liver enzymes (e.g. some seizure medications)
  
  

Avoid using other vaginal products at the same time without medical advice, as they may affect absorption.

The dosage is carefully chosen by your doctor based on your health and reason for use.

Common Regimens:

• For IVF / fertility support:
  
  
  • 200 mg vaginally once or twice daily
    
    
  • Start after embryo transfer or ovulation
    
    
  • Continue until 10–12 weeks of pregnancy
    
    
• For irregular cycles or hormone therapy:
  
  
  • 200 mg once daily, for 10–14 days each cycle
    
    
  • Often combined with estrogen therapy
    
    

General Advice:

• Always take the medicine at the same time every day
  
  
• Don’t skip doses—it may reduce its effectiveness
  
  
• If you miss a dose and it’s close to the next one, skip the missed dose
  
  
• Never take extra without talking to your doctor
  
  

Taking the correct dose at the right time is very important, especially for fertility or pregnancy support.

FIRST-Progesterone VGS 200 is a prescription-only medicine, meaning:

• It must be prescribed by a licensed doctor
  
  
• It’s often managed by fertility specialists, OB/GYNs, or hormone doctors
  
  
• It is not available over-the-counter
  
  
• You must use it under medical supervision
  
  

You may need regular:

• Ultrasounds
  
  
• Blood hormone tests
  
  
• Pregnancy tests
  
  

This helps doctors track your progress and adjust your dose if needed.

In many cases, this medicine is covered by insurance, especially for IVF or hormone therapy. Ask your doctor or pharmacist about any financial support programs that may help.

• What is FIRST-Progesterone VGS 200 used for?
  It is used to replace or supplement natural progesterone in women with hormone deficiency.
  Common indications include:

  • Supporting early pregnancy (after ovulation induction, IVF, or IUI)

  • Treating secondary amenorrhea (absence of menstrual periods)

  • Correcting luteal-phase defects

  • Balancing estrogen during hormone-replacement therapy (HRT)

• What is the brand name?
  FIRST-Progesterone VGS 200® (by CutisPharma).

• What is the active ingredient?
  Progesterone USP (micronized) — a bio-identical form of the natural female hormone progesterone.

• How does it work?

  • Prepares and stabilizes the uterine lining (endometrium) for implantation.

  • Maintains early pregnancy by supporting the corpus luteum phase.

  • Helps regulate the menstrual cycle and counteracts excess estrogen effects.

• What type of medication is it?
  A vaginal progesterone suppository (hormone-replacement / fertility support therapy).

• How is it administered?

  • Insert one vaginal suppository (200 mg) deep into the vagina, usually once or twice daily as directed.

  • Wash hands before and after insertion.

  • Preferably administered at bedtime to minimize leakage.

• What forms and strengths are available?

  • 100 mg and 200 mg vaginal suppositories under the FIRST-Progesterone VGS line.

• How long does it take to work?

  • Hormonal effect begins within a few days.

  • Used continuously through the luteal phase or first trimester in fertility therapy, as directed by a clinician.

• What are the common side effects?

  • Vaginal discharge or mild irritation

  • Breast tenderness or swelling

  • Drowsiness or dizziness

  • Headache or bloating

  • Mood changes

• Are there serious side effects?
  Rare, but possible:

  • Blood clots (DVT, PE) — leg swelling, chest pain, shortness of breath

  • Severe headache or vision changes

  • Depression or severe mood changes

  • Allergic reaction (rash, itching, swelling)

• Who should not use it?

  • Women with breast or uterine cancer

  • Unexplained vaginal bleeding

  • History of blood clots or stroke

  • Severe liver disease

  • Known allergy to progesterone

• Can it be used during pregnancy?
  Yes — commonly prescribed to support early pregnancy, especially after fertility treatments or recurrent miscarriages.

• Can it be used while breastfeeding?
  Usually considered safe in low doses, but discuss with your doctor — small amounts may pass into breast milk.

• Does it interact with other medications?

  • Minimal systemic interactions.

  • Avoid concurrent use of other vaginal products (creams, gels, douches) that can alter absorption.

  • Always inform your provider about any hormone therapies or anticoagulants.

• Can it cause drowsiness?
  Yes — mild sedation is possible; bedtime use is recommended.

• How should it be stored?

  • Keep at controlled room temperature (20 °C–25 °C / 68 °F–77 °F).

  • Protect from heat and moisture.

  • Do not freeze.

• Is there a generic available?

  • Progesterone suppositories are available generically.

  • FIRST-Progesterone VGS 200® is a brand-compounded pharmacy formulation by CutisPharma.

• Where can I get it?
  Available by prescription only, dispensed by pharmacies that prepare and supply FIRST-brand compounded vaginal suppositories.