Common Brands Actos
Drug Class
Controlled Substance Classification
Not a controlled medication
Generic Status
Lower-cost generic available
Prescription only
Robert Chad Hakim, PharmD, BCCCP
Robert Chad Hakim, PharmD, BCCCP
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Medically reviewed by Robert Chad Hakim, PharmD, BCCCP last update on 20/12/2023


Glipizide is a widely prescribed medication belonging to the sulfonylurea class, commonly used in the management of Type 2 diabetes mellitus. As an oral hypoglycemic agent, Glipizide works by stimulating the release of insulin from the pancreas, facilitating glucose uptake by cells, and reducing blood sugar levels.

Mechanism of Action

The primary mechanism of action involves binding to specific receptors on the pancreatic beta cells, leading to increased insulin secretion. This, in turn, enhances the utilization of glucose by peripheral tissues, helping to regulate blood glucose levels.

Types and Formulations

Glipizide is available in various formulations, including immediate-release and extended-release tablets. The immediate-release form is typically taken before meals, while the extended-release version is designed to provide a more sustained effect, requiring less frequent dosing.

Medical Conditions Treated by Glipizide

Type 2 Diabetes Mellitus

Glipizide plays a crucial role in the management of Type 2 diabetes, a chronic condition characterized by insulin resistance and impaired insulin secretion. By promoting insulin release and improving insulin sensitivity, Glipizide helps control blood sugar levels, preventing complications associated with uncontrolled diabetes.

Role in Glycemic Control

The medication is often prescribed as part of a comprehensive treatment plan, which may include lifestyle modifications, dietary changes, and other antidiabetic medications. Its effectiveness in lowering blood glucose levels makes it a valuable tool in achieving glycemic control.



Prescription only

Pregnancy & Lactation