Common Brands Actos
Drug Class
Controlled Substance Classification
Not a controlled medication
Generic Status
Lower-cost generic available
Prescription only
Robert Chad Hakim, PharmD, BCCCP
Robert Chad Hakim, PharmD, BCCCP
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Medically reviewed by Robert Chad Hakim, PharmD, BCCCPlast update on 20/12/2023


Trazodone is a prescription medicine that is most commonly used to treat depression. It belongs to the serotonin modulator class of medicines, which work by influencing neurotransmitter activity in the brain. Trazodone was developed in Italy in the 1960s and was licensed for medicinal use by the FDA in the United States in 1981. 

Apart from its primary application in the treatment of depression, Trazodone is frequently taken for off-label purposes such as improving sleep or lowering anxiety. 

Because of its effectiveness and generally well-tolerated side effect profile, the medication is a popular choice among healthcare practitioners. However, as with any medication, it is critical for patients to understand its purposes, how it works, potential adverse effects, and drug interactions.



Prescription only

Pregnancy & Lactation