Typically, Artiss Duploject is employed in the surgical environment by a trained medical professional. This is a brief description of how it is used:
- Preparation of the surgical site entails washing its surface and making it clean and infection free.
- Activation of Duploject Syringe – The dual chambered syringe is activated to allow combination of fibrinogen and thrombin. There is a provision in the double barrel syringe that ensures accordance in expressing the components
- Application Using the syringe, the healthcare provider dispenses the mixture of fibrinogen and thrombin onto the wound/scalpel site. The components upon reaching the tissue surfaces of the patient will form a clot soonest possible.
4. Clot Formation As a result of this, a fibrin clot is formed which a tissue thrombin glue activated the fibrinogen. This usually takes few seconds to a minute for complete adhesion.
The Artiss Duploject system relies on the inherent clotting processes of the body. A mixture of fibrinogen and thrombin, when brought into contact with a wound or surgical site, allows thrombin to expedite the transformation of fibrinogen to fibrin, thus producing a firm structure known as a clot.
The fibrin clot performs multiple functions:
- Hemostasis: As a natural response to bleeding, this type of clot helps to seal off damaged blood vessels in the area of trauma.
- Tissue Adhesion: The clot also forms connection with the surrounding tissue, reinforcing and controlling the outflow from the surgical area.
- Wound Healing: A fibrin matrix is also present, which serves to assist in the migration of cells into the particular area requiring repair.
With the usage of the Duploject delivery system the surgical team is able to deliver the exact required amount of fibrinogen and thrombin at the operation site which allows an effective and uniform clotting process.
Despite the general safety profile of Artiss Duploject, as with every medicinal product, there may be some side effects. Such effects are usually infrequent but include:
- Infection: There is a possibility of an infection occurring at the site of wound in case of contamination of the product or incorrect usage of the product.
- Tissue Death: Rarely, inappropriately inc luded or too much of a substance may cause tissue death, particularly when a tissue adhesive serum is applied in the wrong kinds or too much tissue, in the wrong kinds.
• Reactions at the local level: Pain, swelling or tenderness may occur in some patients at the application area.
The use of Artiss Duploject should be restricted to selected healthcare applications, and the following warnings and precautions need to be taken into account by all practitioners:
- Allergy History: The use of Artiss Duploject is contraindicated in patients with a history of allergy to any human blood product, including but not limited to, fibrinogen or thrombin.
- Not for Large Body Cavities: Patients are advised not to use Artiss Duploject on large body cavities (such as the chest and abdominal) or in areas that can accommodate large quantities of fluids.
• Infected Wounds: The use of Artiss Duploject is contraindicated in infected or septic tissues. It is to be used only on clean, properly prepared tissues.
Anticoagulants: Artiss Duploject may share its effects with anticoagulant medications like warfarin, heparin, and direct oral anticoagulants. These increase the likelihood of bleeding which is a potential factor regarding the effectiveness of Artiss Duploject in sealing tissues and bleeding during surgery.
Antiplatelet agents: Antiaggregants such as aspirin and clopidogrel intend to affect the clotting process, and at the same time, may interact with the effectiveness of Artiss Duploject, resulting in overly excessive bleeding during and after surgery.
Other Fibrinogen or Thrombin-based Products: Co-administration of Artiss Duploject with other fibrinogen or thrombin-derived hemostatic agents could lead to unpredictable coagulation action or excessive clotting complications.
Allergic reactions to Artiss Duploject: Artiss Duploject contains human-derived proteins. Therefore, patients previously known for an allergic reaction to fibrinogen or thrombin would also experience allergic reactions complicating its use.
It is important that healthcare providers be told about all the medications patients take before surgery for proper precautions against harmful interactions to be able to keep Artiss Duploject as safe and effective as possible.
Dosage for Artiss Duploject varies with the size of the wound or surgical area. The dual chamber syringe is intended for one-time use and the correct volume of the product should be applied straight to the site.
As it is or may be used in an operating room environment, the dosage is dependent on the operating surgeon and the type of surgery and tissue in question. There are no particular “normal” adverse effects dosage schematics, owing to the use of Artiss Duploject being fully dependent upon the variables presented by the surgical patient.
Artiss Duploject is a licensed medicine which means that it can only be dispensed and administered by qualified healthcare professionals in either a clinical or surgical environment.
It cannot be bought over the counter and must be used only under the supervision of a trained and qualified person as it relates to its usage.