| Common Brands | Belviq (brand no longer available) |
|---|---|
|
Drug Class |
Serotonin agonist |
|
Controlled Substance Classification |
Schedule IV |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Discontinued |
Belviq is a prescription weight loss medication. It was prescribed for the treatment of weight loss in adults who were either overweight (BMI ≥ 27 kg/m²) with obesity-related conditions, such as high blood pressure, type 2 diabetes, or high cholesterol, or those with obesity (BMI ≥ 30 kg/m²). The drug was intended to help patients lose weight by working on the brain to produce feelings of fullness, thereby reducing appetite. Belviq is classified under serotonin receptor agonists.
Belviq was approved by the FDA back in 2012 for immediate marketing in conjunction with a reduced-calorie diet and increased physical activity as part of a comprehensive weight management program. However, it was withdrawn from the market by the manufacturer, Eisai, in February 2020 because of safety concerns that could arise from a potential long-term risk of cancer. It was withdrawn based on interim results from an ongoing clinical trial.
When Belviq was available, it was administered usually once in the morning and once in the evening. The standard dose prescribed for the patient was 10 mg.
Dosage: Belviq was normally given in a dosage of 10 mg. The amount taken must always be strictly in accordance with the prescription to avoid taking more than what was recommended.
Administration: The oral tablet form of Belviq could be administered with or without food.
Missed Dose: A patient should be advised to take the missed dose as soon as they remember it except in cases where a dose is almost due, and at that time they should skip it and continue taking their dosages regularly.
It should be noted that Belviq should have been part of a comprehensive weight management program, which included a reduced-calorie diet and regular physical activity.
Belviq’s primary mechanism of action occurs through its selective agonist activity at the 5-HT2C serotonin receptors located within the brain, primarily the areas including hypothalamus that deal with issues of appetite and eating behavior. It enhances the secretion of serotonin by stimulating those receptors, thereby increasing feelings of satiety, hence diminishing the urge to consume more food.
Unlike most other weight loss drugs that are focused on inhibiting fat absorption or suppressing appetite through other mechanisms, Belviq works on the serotonin receptors to control hunger and satiety. The drug does not have a direct effect on the body’s metabolism or fat burning but rather reduces the psychological urge to eat, which aids users in maintaining a calorie deficit and losing weight over time.
Belviq, like any medication, could cause side effects. Some of the most common and serious side effects of Belviq included:
Headache: Many users reported headaches as a common side effect of taking Belviq.
Dizziness: Some people experienced dizziness, especially when standing up quickly.
Fatigue: Patients on Belviq were mostly complaining of fatigue or tiredness.
Nausea: Nausea or gastrointestinal disturbance was reported by some patients.
Low Blood Sugar (Hypoglycemia): Belviq, in combination with other diabetes medications, may cause low blood sugar, which can be associated with symptoms such as sweating, shakiness, confusion, and dizziness.
Heart Valve Problems: There was a suspected risk of valvular heart disease with Belviq, although this was not proven in clinical studies.
Although Belviq was effective for many subjects in losing the weight, there were some very essential warnings that should be read and understood.
Cancer Risk: The FDA mandated that Belviq be marketed with a boxed warning regarding its potential to increase the risk of cancer. A study revealed an increased incidence of cancer in people who were taking lorcaserin, though the exact nature of the relationship between the drug and cancer risk was not well understood. This led to the withdrawal of Belviq from the market.
Pregnancy Category X: Belviq was not recommended for use during pregnancy, as it could harm a developing fetus.
Severe Heart Valve Disease: Patients with a history of heart valve disease or other heart issues were advised against using Belviq due to concerns about potential risks to the heart.
Drug Interactions: Belviq may interact with other medications that raise serotonin levels. Examples include antidepressants, specifically SSRIs, triptans, and other serotonergic drugs. This would elevate the risk of serotonin syndrome.
Serotonergic Drugs: Combining Belviq with other medications that increase serotonin levels, such as SSRIs or SNRIs, may lead to serotonin syndrome, which can cause symptoms like agitation, high body temperature, or muscle rigidity.
CNS Depressants: Using Belviq with sedatives, alcohol, or other central nervous system depressants can increase the risk of drowsiness, confusion, or difficulty concentrating.
Antidiabetic Medications: Belviq may enhance the effect of antidiabetic drugs, leading to an increased risk of hypoglycemia (low blood sugar), especially when combined with insulin or sulfonylureas.
Blood Pressure Medications: When taken with antihypertensive drugs, Belviq may increase the risk of low blood pressure or dizziness, especially when standing up quickly.
The standard dose for Belviq was 10 mg taken twice a day. Doses above this were not advised. In the treatment of weight loss, Belviq was administered in conjunction with a reduced-calorie diet and exercise.
Dosage adjustments should be discussed with the doctor if a patient is having trouble taking the medication.
Belviq should be only used under a healthcare provider’s advice if another weight-loss drug or appetite suppressant is taken.
Belviq could only be obtained by prescription through a health care professional who had to evaluate a patient’s weight, general health and medical conditions in order to deem Belviq appropriate as a treatment.
Due to concerns regarding cancer risk, as well as the overall safety profile, Belviq was withdrawn from the market in February 2020, and it is no longer available through prescription.
What is Belviq?
Belviq is a prescription medication used to help adults manage weight by decreasing appetite and promoting a sense of fullness.
How does Belviq work?
Belviq works by activating serotonin receptors in the brain, which helps control appetite and reduces food intake.
Who is a suitable candidate for Belviq?
Belviq is intended for adults who are overweight or obese and have health-related conditions, such as type 2 diabetes or high blood pressure.
What is the recommended dosage for Belviq?
The typical starting dose is 10 mg taken twice daily, but it may be adjusted based on individual response and tolerability.
What are the common side effects of Belviq?
Common side effects may include headaches, dizziness, fatigue, nausea, and dry mouth.
Can Belviq be taken with other medications?
It is important to inform your healthcare provider about any other medications you are taking, as Belviq can interact with certain drugs.
Is Belviq a controlled substance?
No, Belviq is not classified as a controlled substance, but it should still be used under a doctor’s supervision.
How long can I take Belviq?
Treatment duration varies; your healthcare provider will determine how long you should take Belviq based on your weight loss goals and health status.
Can I drink alcohol while taking Belviq?
Alcohol should be consumed cautiously, as combining it with Belviq may increase the risk of side effects such as dizziness and drowsiness.
What should I do if I miss a dose of Belviq?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule.
Can Belviq cause dependency?
Belviq is not known to cause physical dependence, but it should be used as part of a comprehensive weight management plan.
Are there serious side effects associated with Belviq?
Serious side effects can include hallucinations, serotonin syndrome, and heart valve problems, so it is crucial to monitor for unusual symptoms.
Is Belviq suitable for everyone?
Belviq may not be suitable for individuals with a history of certain medical conditions, including heart disease or those who are pregnant or breastfeeding.
What should I tell my doctor before starting Belviq?
Inform your doctor about your medical history, particularly any previous heart conditions, mental health issues, or drug allergies.
Does Belviq affect metabolism?
Belviq primarily reduces appetite rather than directly altering metabolism, which can influence weight loss.
What lifestyle changes should I make while taking Belviq?
For optimal results, it’s recommended to combine Belviq with a healthy diet and regular exercise.
Can I stop taking Belviq suddenly?
While it’s generally not necessary to taper off Belviq, you should always consult your healthcare provider before discontinuing any medication.
Where can I find more information about Belviq?
You can find more details from your healthcare provider, pharmacist, or reputable medical websites.
Is Belviq covered by insurance?
Coverage for Belviq may vary based on your insurance plan, so it’s best to check with your provider for specific details.
What should I do if I experience side effects while taking Belviq?
If you experience any concerning side effects, you should contact your healthcare provider for guidance and possible adjustments to your treatment plan.
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