Bryhali is typically applied to the affected areas once a day. It is important to follow the instructions provided by your healthcare provider to ensure the medication is used effectively and safely:

Application: Apply a thin layer of Bryhali cream or ointment on the affected skin area. In general, it should be done once a day. Massage gently to ensure absorption. Apply this medication in the face, groin, and underarms unless directed by your doctor, since these areas have high possibilities of developing side effects.

Amount to use: A very small amount of the cream or ointment is usually enough to treat the area affected by the condition. Overuse of this product promotes the risk for side effects, including thinned out skin.

Contact with the eyes should be avoided, and if your eyes contact Bryhali, just rinse the eye with lots of water immediately.

Always wash your hands after applying the Bryhali to prevent transmitting it to other parts of your body or to others.

Halobetasol propionate, the active ingredient in Bryhali, is a potent corticosteroid. Corticosteroids like halobetasol work by binding to glucocorticoid receptors in the skin cells, which subsequently leads to a decrease in the production of inflammatory substances such as prostaglandins, leukotrienes, and cytokines. These inflammatory molecules are responsible for the redness, swelling, and itching that are characteristic of conditions like psoriasis and eczema.

In addition to anti-inflammatory action, halobetasol propionate suppresses the activity of the skin’s immune cells responsible for plaque formation in psoriasis. Suppression of immune responses by Bryhali leads to a decrease in the size and number of plaques, hence smoothening and relieving irritation on the skin.

Just like with any medication, Bryhali can cause side effects. Due to its potency, one should be aware of a specific adverse effect that could result from prolonged use. Common and serious side effects are:

Skin irritation or burning: Some patients may feel a mild irritation or burning sensation when applying the cream or ointment, especially in the first few applications.

Dry skin: The treated skin area may become dry or cracked, which is a common side effect of topical corticosteroids.

Skin thinning: The use of high-potency corticosteroids like Bryhali for a long time may cause the skin to become thin (atrophy), and the skin becomes more fragile and easily bruised and torn.

If any of these side effects happen, a healthcare provider should be contacted right away.

There are several important warnings and precautions that need to be taken while using Bryhali:

Not to be used for extended periods or over extensive areas of the skin unless directed by a healthcare provider; long-term or excessive use will lead to serious side effects which include skin thinning and absorption into the body.

Avoid eyes and mucous membranes: Apply Bryhali to the affected area but avoid application to the eyes, lips, or mucous membranes. It causes irritation if applied to the mucous membranes.

Children: In general, it is not recommended to use high potency corticosteroids such as Bryhali in children because their skin is more sensitive, and they are at higher risk of systemic absorption and thus side effects like growth suppression.

Pregnancy and breastfeeding: Bryhali is used during pregnancy or breastfeeding only if the potential benefits outweigh the risks. There is limited data regarding the use of halobetasol propionate during pregnancy. Corticosteroids are known to cross the placenta. Consult a healthcare provider before using Bryhali during pregnancy or while nursing.

1. CYP3A4 Inhibitors: Medications like ketoconazole may increase the levels of Bryhali in the blood, potentially leading to an increased risk of side effects such as skin irritation.
2. Corticosteroids: Using Bryhali alongside oral or systemic corticosteroids may increase the risk of systemic corticosteroid side effects, including adrenal suppression.
3. Other Topical Steroids: Combining Bryhali with other topical corticosteroids may increase the likelihood of side effects such as thinning skin or delayed wound healing.
4. Immunosuppressive Medications: Medications that suppress the immune system, such as methotrexate, may increase the risk of infections when used with Bryhali.

Always discuss with your healthcare provider before using Bryhali with other medications to ensure safety and effectiveness.

The usual dose of Bryhali is the thin layer to be applied over the affected areas, once daily. The period of treatment again depends on the condition itself, but in most cases it is prescribed for short-course treatment; this means generally up to 2 weeks. Treatment duration can, however, be altered as per individual response and even the region being treated under the prescription of a health professional.

Due to the high potency of Bryhali, it is generally not recommended over large areas or for extended periods of time to avoid systemic side effects.

Bryhali is a prescription drug. It can only be accessed with a prescription from a doctor. A healthcare provider will assess the patient’s condition and determine if Bryhali is an appropriate treatment option. Regular follow-up appointments may be necessary to monitor the patient’s response to treatment and to address any potential side effects.

1. What is Bryhali used for?
   Bryhali is a medication used to treat moderate to severe plaque psoriasis in adults and is designed to improve skin conditions by reducing inflammation.

2. How does Bryhali work?
   Bryhali is an interleukin-23 (IL-23) inhibitor. It works by targeting and inhibiting specific proteins involved in the inflammatory process of psoriasis, helping to reduce symptoms.

3. What is the recommended dosage of Bryhali?
   The typical dosing regimen for Bryhali is an initial dose followed by maintenance doses, usually administered every 12 weeks after the loading doses, but your healthcare provider will determine the exact dosage.

4. How is Bryhali administered?
   Bryhali is administered as a subcutaneous injection (under the skin), typically in the thigh, abdomen, or upper arm.

5. Can Bryhali be used in combination with other treatments?
   Yes, Bryhali can be used with other psoriasis treatments, including phototherapy and topical medications, but consult your healthcare provider about any potential interactions.

6. What are the common side effects of Bryhali?
   Common side effects may include injection site reactions, headache, and mild respiratory infections. Most side effects are not serious, but you should report any that persist.

7. Are there serious side effects associated with Bryhali?
   Serious side effects can include allergic reactions, infections (due to immune suppression), and severe skin reactions. It’s important to notify your healthcare provider if you notice any concerning symptoms.

8. Can Bryhali be taken during pregnancy or breastfeeding?
   The safety of Bryhali during pregnancy and breastfeeding isn’t fully established. Discuss potential risks and alternatives with your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding.

9. How long does it take to see results from Bryhali?
   Many patients may notice improvement in their psoriasis symptoms within a few weeks, but full effects might take several months to become apparent.

10. What should I do if I miss a dose of Bryhali?
    If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and return to your regular schedule. Do not double the dose.

11. How should Bryhali be stored?
    Bryhali should be stored in the refrigerator but can be kept at room temperature for up to 30 days if not used. Protect it from light.

12. Is Bryhali safe for elderly patients?
    Bryhali can be prescribed to elderly patients, but they may be more prone to side effects. Dosing and monitoring should be adjusted accordingly based on the individual’s health status.

13. What should I inform my doctor before starting Bryhali?
    Inform your doctor about your medical history, including any previous infections, allergies, and other medications you are currently taking to assess your suitability for Bryhali.

14. Does Bryhali affect the immune system?
    Yes, Bryhali may affect the immune system as it blocks a key inflammatory pathway, which can increase the risk of infections. Regular monitoring may be necessary during treatment.

15. Can I drink alcohol while taking Bryhali?
    While there are no specific contraindications regarding alcohol, it’s advised to limit alcohol consumption as it could affect your overall health and well-being.

16. Will I need regular monitoring while on Bryhali?
    Yes, your healthcare provider will likely schedule regular follow-ups to monitor your response to treatment and check for potential side effects.

17. Are there any contraindications for using Bryhali?
    Bryhali should not be used in patients with a known hypersensitivity to briakinumab or any of its components. Your doctor will screen for these and other potential contraindications.

18. Can Bryhali affect my ability to drive or operate machinery?
    Bryhali generally does not impair coordination or judgment. However, you should assess how you feel after your injections before driving or operating machinery.

19. Is Bryhali covered by the insurance?
    Insurance coverage for Bryhali varies by plan. It is advisable to check with your insurance provider regarding coverage details and any necessary pre-authorization.

20. Where can I find more information about Bryhali?
    For more information, consult the patient information leaflet provided with your medication, visit the manufacturer’s website, or speak with your healthcare provider for personalized advice.