| Common Brands | Dovonex, Sorilux |
|---|---|
|
Drug Class |
Antipsoriatic (Vitamin D analog) |
|
Controlled Substance Classification |
Not a controlled medication |
|
Generic Status |
Lower-cost generic available |
|
Availability |
Prescription only |
Calcipotriene, also known as calcipotriene topical, is a synthetic vitamin D3 derivative that is primarily used in the treatment of psoriasis, which is a chronic autoimmune condition characterized by the rapid overproduction of skin cells that causes scaling, redness, and inflammation. It slows down the excessive proliferation of skin cells and diminishes inflammation, thus providing relief from the symptoms of psoriasis.
This drug is applied directly to the skin in the form of creams, ointments, or solutions. Calcipotriene is a part of a broader class of drugs known as topical treatments for psoriasis and works by mimicking the effects of natural vitamin D, which plays a crucial role in skin cell growth and differentiation.
Calcipotriene topical is usually applied to the areas of the skin that have been affected once or twice daily. Specific usage directions may vary depending on the intensity of psoriasis and form of calcipotriene prescribed. Below is a general guide:
Application Instructions:
Clean and dry the affected area of the skin before applying the medicine.
Apply a thin layer of calcipotriene cream, ointment, or solution directly to the psoriasis plaques.
Apply the product gently, without touching healthy skin, as it is only for the areas that are affected.
Do not apply the treatment on sensitive areas such as the face, groin, and armpits unless told to do so by a healthcare provider.
The mechanism of action of calcipotriene topical is based on its ability to regulate skin cell turnover. Here’s how it works:
Vitamin D Receptor Binding: Calcipotriene is a vitamin D analog, meaning that it mimics the action of natural vitamin D. Applied topically, it binds to vitamin D receptors on skin cells (keratinocytes).
Inhibition of Cell Proliferation: By binding on these receptors, calcipotriene inhibits the rapid proliferation (growth) of skin cells; a hallmark of psoriasis. This slows down an excessive formation of scaly plaques and reduces the inflammation.
Normalizing Differentiation of Skin: Medication also helps regulate a process of differentiation of a skin cell, encouraging them to become normal skin rather than immature, rapidly proliferating cells seen in lesional psoriasis.
Though calcipotriene is generally well-tolerated, it may cause side effects, especially with prolonged use or overuse. Some common and less common side effects include:
Skin Irritation: Redness, itching, or burning sensation at the site of application is a common side effect, particularly when first starting treatment.
Dry Skin: The skin may become dry or cracked with prolonged use, and moisturizing may be required.
Photosensitivity: Some patients may become sensitive to the sun during treatment with calcipotriene, thus putting them at a higher risk of developing sunburn.
Hypercalcemia: High consumption of calcipotriene may cause elevated calcium levels in the blood (hypercalcemia). It is characterized by signs such as nausea, vomiting, weakness, or renal failure.
There are certain precautions associated with the use of topical calcipotriene:
Avoid Overuse: Overuse of calcipotriene increases the risk of side effects including hypercalcemia or irritation of the skin.
Sensitive Areas: Avoid applying the medication to sensitive areas like the face, armpits, groin, or genitals, unless directed by a healthcare provider. The skin in these areas is more likely to absorb the medication, increasing the risk of side effects.
Sun Exposure: Prolonged exposure to sunlight should be limited, as calcipotriene can increase sensitivity to the sun, leading to a higher risk of sunburn.
Children: Calcipotriene use in children under 12 years should be under the care of a healthcare provider because it has not been well studied for safety and efficacy in children younger than that.
Corticosteroids: When used with corticosteroids, calcipotriene may increase the risk of skin irritation, so careful monitoring is necessary.
Tazarotene: Combining calcipotriene with tazarotene, a topical retinoid, can increase skin dryness or irritation, requiring dose adjustments.
Other Vitamin D Analogues: Concurrent use with other vitamin D analogs could increase the risk of hypercalcemia (elevated calcium levels), leading to potential toxicity.
Topical Antifungals: Topical antifungals generally don’t interfere with calcipotriene, but should be used cautiously to prevent excessive irritation.
The dose of topical calcipotriene to be used would depend on the severity of the disease and the individual patient’s circumstances. General recommendations include:
Adults: Apply a thin layer to the affected area once or twice a day. Total weekly application should not exceed 100 g.
Children: For patients under 12 years old, a healthcare provider would determine the appropriate dose.
For best results, follow the instructions provided by the healthcare provider, and do not exceed the recommended dosage or duration of use.
Calcipotriene topical is a prescription drug. A doctor will determine the appropriate treatment based on the severity of the psoriasis and the patient’s
Medical history. It may be prescribed with other treatments, such as corticosteroids or phototherapy, to give more complete relief.
Because calcipotriene is a topical treatment, it carries fewer risks of systemic side effects than oral medications, but it is still necessary to monitor its use to avoid overuse and ensure that the medication is working.
What is Calcipotriene Topical?
How does Calcipotriene work on the skin?
What conditions is Calcipotriene Topical used to treat?
Who might benefit from using Calcipotriene Topical?
How is Calcipotriene Topical applied?
What is the recommended frequency of application?
What are common side effects of Calcipotriene Topical?
Are there any serious side effects associated with Calcipotriene?
Who should avoid using Calcipotriene Topical?
What precautions should be taken before using Calcipotriene?
Can Calcipotriene Topical interact with other medications?
Is it safe to use Calcipotriene with other psoriasis treatments?
Should Calcipotriene be used with sunscreen?
How long does it take for Calcipotriene to show results?
Where can I find more information about Calcipotriene?
What should I do if I miss a dose of Calcipotriene?
What resources are available for patients using Calcipotriene?
What should I do if I have concerns about using Calcipotriene Topical?
Is Calcipotriene Topical safe for pregnant or breastfeeding women?
Is Calcipotriene suitable for children?
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