Canasa PAC is intended to be used as a rectal suppository. Here’s how it is typically administered:

1. Preparation:
   • Wash your hands thoroughly before and after using the suppository.
   • Unwrap the suppository from its packaging. It may be helpful to moisten the suppository slightly with water to make insertion easier.
2. Insertion:
   • Lie on your left side with your left leg bent towards your chest (the left lateral position).
   • Gently insert the suppository into the rectum, aiming it towards the back of the rectum.
   • Try to retain the suppository for several hours, ideally overnight, to allow the medication to work effectively.
3. Aftercare:
   • After inserting the suppository, remain in a comfortable position for a period of time to help retain the medication.
   • Wash your hands thoroughly after handling the suppository.

Note: It is important to follow the instructions provided by your healthcare provider or the manufacturer’s guide for the correct use of Canasa PAC. Do not crush, chew, or break the suppository.

Canasa PAC (rectal) contains the active ingredient mesalamine, an anti-inflammatory drug used to treat conditions involving inflammation in the intestines, particularly ulcerative colitis. It is available in a suppository form that is inserted into the rectum. The formulation is designed to deliver the medication directly to the affected area of the lower gastrointestinal tract, where it can reduce inflammation and prevent further damage.

• Mesalamine: The active drug in Canasa belongs to the class of medications known as 5-aminosalicylates. These drugs work by inhibiting the production of inflammatory substances in the colon, particularly prostaglandins and leukotrienes, which contribute to the inflammation and symptoms of ulcerative colitis.

Indication: Canasa is mainly prescribed for the treatment of mild to moderate ulcerative proctitis (inflammation of the rectum), a form of ulcerative colitis that affects only the rectum.

While Canasa PAC is generally well-tolerated, there can be some side effects. Common side effects associated with mesalamine include:

• Rectal discomfort: Some patients may experience irritation or discomfort at the site of insertion.
• Gastrointestinal side effects: These may include nausea, diarrhea, abdominal pain, or flatulence.
• Headache: Some individuals may develop headaches during treatment.
• Allergic reactions: In rare cases, mesalamine can cause an allergic reaction, leading to symptoms like rash, itching, or swelling, particularly around the face or throat.
• Blood disorders: Though uncommon, mesalamine can affect blood cell counts, leading to conditions like leukopenia (low white blood cell count), thrombocytopenia (low platelet count), or anemia.

Serious side effects:

• Kidney problems: Rarely, mesalamine can cause kidney damage, particularly in patients with pre-existing kidney conditions. Kidney function should be monitored during treatment.

Liver issues: Liver toxicity, although rare, can also occur. Patients should have regular liver function tests while on Canasa.

Before using Canasa PAC, there are several important considerations:

• Allergic reactions: Patients who have a history of hypersensitivity to mesalamine, sulfasalazine, or other aminosalicylates should not use Canasa.
• Kidney function: Mesalamine can affect kidney function, so patients with a history of kidney disease should use Canasa with caution. Kidney function should be monitored regularly.
• Liver issues: Patients with liver disease should be monitored closely for signs of liver toxicity while using Canasa.
• Pregnancy and breastfeeding: Canasa is classified as Category B for pregnancy, which means it is generally considered safe for use during pregnancy, but it should only be used if clearly needed. It is unknown if mesalamine passes into breast milk, so consult a healthcare provider before using Canasa while breastfeeding.
• Drug interactions: As mentioned earlier, Canasa can interact with other medications, including blood thinners and other gastrointestinal drugs. Always inform the healthcare provider about all other medications being taken.

• Aminosalicylates (e.g., sulfasalazine): Since Canasa contains mesalamine, which is related to other aminosalicylates, patients should be monitored for potential interactions with these drugs. Concurrent use with sulfasalazine or other aminosalicylates may increase the risk of side effects.
• Blood-thinning medications (anticoagulants): Mesalamine can interact with blood-thinning medications like warfarin, potentially increasing the risk of bleeding.
• Other gastrointestinal medications: Medications that alter the motility or absorption of the gastrointestinal tract may affect the efficacy of Canasa. These should be discussed with a healthcare provider before starting treatment.

• Typical dose: The usual dosage of Canasa PAC for ulcerative proctitis in adults is 1 suppository (1000 mg of mesalamine) once daily, typically before bedtime.
• Children: The use of Canasa PAC in children should be guided by a healthcare provider. The appropriate dosage depends on the child’s age, weight, and the severity of the condition.
• Adjustment: The dose may be adjusted based on the patient’s response to treatment, and the doctor may recommend a lower or higher dosage depending on individual needs.

Canasa PAC (rectal) is available by prescription only. A healthcare provider will evaluate the patient’s medical condition and determine if Canasa is the right treatment. Patients will need to follow their provider’s instructions carefully and may need regular check-ups to monitor their response to treatment and detect any potential side effects.

1. What is Canasa PAC?

   • Canasa PAC is a rectal suppository medication containing mesalamine, used for the treatment of ulcerative colitis.

2. How does Canasa PAC work?

   • It works by reducing inflammation in the intestinal lining, helping to relieve symptoms of ulcerative colitis.

3. What conditions is Canasa PAC used to treat?

   • It is primarily used to treat mild to moderate ulcerative colitis and may also be used for other inflammatory bowel diseases.

4. How should I use Canasa PAC?

   • Canasa PAC should be used as directed by your healthcare provider, typically inserted rectally once daily, preferably at bedtime.

5. What should I do if I miss a dose of Canasa PAC?

   • If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

6. Are there any side effects of Canasa PAC?

   • Common side effects may include abdominal pain, diarrhea, headache, or rectal discomfort. Serious side effects are rare but can occur.

7. Can Canasa PAC be used during pregnancy?

   • Yes, but you should consult your healthcare provider to weigh the benefits and risks before using it during pregnancy.

8. Is it safe to use Canasa PAC while breastfeeding?

   • It is generally considered safe, but you should discuss it with your doctor to ensure it’s appropriate for your situation.

9. Can I drink alcohol while using Canasa PAC?

   • It’s best to avoid alcohol while on Canasa PAC, as it may increase the risk of gastrointestinal side effects.

10. What should I do if I experience severe side effects?

    • If you experience severe symptoms such as rash, fever, chest pain, or unusual bleeding, seek medical attention immediately.

11. Are there any drug interactions with Canasa PAC?

    • Yes, inform your healthcare provider about all medications you are taking, as some drugs may interact with mesalamine.

12. Can Canasa PAC be used long-term?

    • Yes, many patients use Canasa PAC long-term, but regular follow-ups with your healthcare provider are necessary to monitor your condition.

13. How should Canasa PAC be stored?

    • Store Canasa PAC at room temperature, away from moisture and heat, and keep it out of reach of children.

14. Can Canasa PAC cause allergic reactions?

    • Yes, some people may have an allergic reaction to mesalamine. Symptoms can include rash, itching, or swelling. Seek medical help if you notice these symptoms.

15. What if Canasa PAC doesn’t work for me?

    • If you find that Canasa PAC is not effective in managing your symptoms, consult your healthcare provider about alternative treatments.

16. Can Canasa PAC be used alongside other ulcerative colitis medications?

    • Yes, but only under the guidance of your healthcare provider to avoid potential interactions.

17. What is the recommended dosage for Canasa PAC?

    • The typical dosage for adults is a single 1000 mg suppository inserted rectally once daily at bedtime. Always follow your doctor’s instructions.

18. Can I use Canasa PAC after surgery?

    • Consult your healthcare provider, as they will assess your individual situation regarding surgery and medication use.

19. Does Canasa PAC help in preventing ulcerative colitis flare-ups?

    • Yes, it can help maintain remission and prevent flare-ups when used appropriately.

20. Where can I find more information about Canasa PAC?

    • For more information, consult your healthcare provider or visit the official product website and medication guides.