Chlophedianol (Phenylephrine) and Pyrilamine

Common Brands Neo-Chlorphen, Sinutab-P, Phenyletrinyl
Drug Class
Decongestant (Phenylephrine) + Antihistamine (Pyrilamine)
Controlled Substance Classification
Not a controlled medication
Generic Status
Lower-cost generic available
Availability
Prescription and some OTC depending on the country
Shifali Patel, PharmD
Shifali Patel, PharmD
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Medically reviewed by Shifali Patel, PharmD last update on 20/12/2023

Overview

Chlophedianol (Phenylephrine) and Pyrilamine are often combined in over-the-counter medications, especially in formulations aimed at relieving symptoms of common colds, allergies, and upper respiratory tract infections. These combination drugs typically target symptoms like nasal congestion, sneezing, runny nose, and mild cough. This combination works by utilizing the distinct actions of its active ingredients:

  • Chlophedianol: An antihistamine and antitussive (cough suppressant), it works by blocking the effects of histamine (a chemical involved in allergic responses) and helps suppress cough.
  • Phenylephrine: A decongestant that works by constricting the blood vessels in the nasal passages, leading to reduced swelling and congestion.
  • Pyrilamine: Another antihistamine, which helps control allergic reactions, such as sneezing, runny nose, and itching.

These ingredients work together to provide comprehensive relief from multiple cold and allergy symptoms.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

Pregnancy

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