Daliresp comes in tablet form and should be taken as prescribed. Here’s how to use it:

• Take Exactly as Prescribed: It is essential to follow your doctor’s instructions carefully. Never take more than the prescribed amount.
• Take Once a Day: Daliresp is typically taken once daily. Try to take it at the same time every day to help remember.
• With or Without Food: You can take Daliresp with or without food. However, it is important to swallow the tablet whole without crushing or chewing it.
• Missed Dose: If you miss a dose, take it as soon as you remember, unless it’s close to the time for your next dose. In that case, skip the missed dose and take your next dose as usual. Never take two doses to make up for a missed one.

Always follow your doctor’s instructions for how to take Daliresp.

Daliresp works by targeting a specific enzyme, phosphodiesterase-4 (PDE4), which is involved in inflammation in the lungs. In people with COPD, inflammation in the airways can cause symptoms like coughing, wheezing, and shortness of breath. Here’s how Daliresp works:

• Inhibiting PDE4: By inhibiting PDE4, Daliresp reduces the breakdown of certain substances in the lungs that promote inflammation. This action helps decrease swelling and mucus production in the airways, making breathing easier.
• Reducing Airway Inflammation: The reduction of inflammation in the lungs helps keep the airways open and improves airflow, which makes it easier to breathe and reduces the frequency of COPD flare-ups.
• Preventing COPD Flare-ups: By managing inflammation, Daliresp helps reduce the risk of sudden worsening of COPD symptoms (called flare-ups), which can lead to hospitalization and other complications.

Although Daliresp does not cure COPD, it helps control the symptoms and prevent the condition from getting worse over time.

Like all medications, Daliresp can cause side effects, although not everyone will experience them. Some common side effects include:

• Diarrhea: A common side effect, especially when starting the medication.
• Headache: Some people may experience headaches, particularly during the first few weeks of treatment.
• Nausea: Mild nausea can occur, especially when starting the medication.
• Loss of Appetite: Some people may lose their appetite while using Daliresp.

Serious side effects, although rare, can include:

• Mood Changes: Daliresp may cause changes in mood, including depression or anxiety. In some cases, suicidal thoughts have been reported, so it’s important to monitor for any unusual mood changes.
• Liver Problems: Since Daliresp is processed by the liver, it can cause liver problems in rare cases. Your doctor may monitor liver function during treatment.
• Severe Allergic Reactions: Though rare, some individuals may experience severe allergic reactions, including rash, itching, swelling, or difficulty breathing.

If you experience any of these serious side effects, contact your healthcare provider immediately.

Before starting Daliresp, consider the following:

• Mental Health Concerns: Daliresp may cause mood changes, including depression and thoughts of suicide. If you have a history of mental health problems, discuss this with your doctor before starting the medication.
• Liver Problems: If you have liver issues, your doctor may adjust the dose or suggest alternative treatment options. Regular monitoring of liver function may be necessary.
• Pregnancy and Breastfeeding: The safety of Daliresp during pregnancy and breastfeeding has not been fully studied. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Other Health Conditions: Inform your doctor if you have any other medical conditions, such as kidney disease or infections, as these may affect how Daliresp works.

Daliresp can interact with other medications, so it’s important to inform your doctor about all the drugs you are taking. Some key interactions include:

• Liver Enzyme Inhibitors: Medications that affect liver enzymes, such as ketoconazole (an antifungal), can increase the levels of Daliresp in the body, potentially increasing the risk of side effects.
• Other Medications for COPD: Daliresp is often taken alongside other medications for COPD, such as bronchodilators (e.g., albuterol). Be sure to follow your doctor’s instructions carefully to ensure proper management of your condition.
• CYP450 Enzyme System: Daliresp is metabolized in the liver by certain enzymes. Other medications that affect this enzyme system may change how Daliresp works or increase the likelihood of side effects.

Always discuss your complete medication list with your healthcare provider to avoid potential interactions.

The recommended dosage for Daliresp is 500 mcg once daily. Be sure to follow the dosage instructions carefully, and never take more than the prescribed amount.

If you miss a dose, take it as soon as you remember, but if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Daliresp is available only with a prescription from your healthcare provider. Your doctor will assess your COPD and decide if this medication is right for you. They will monitor your progress and adjust the dosage if necessary.

If you have any concerns about using Daliresp, consult your doctor for more information and guidance.

1. What is Daliresp used for?
   Daliresp is used to reduce the risk of COPD flare-ups in people with severe chronic obstructive pulmonary disease, especially those with chronic bronchitis.

2. How does Daliresp work?
   It works by decreasing inflammation in the lungs through inhibition of the PDE4 enzyme.

3. Is Daliresp a rescue inhaler?
   No, Daliresp is not a rescue medication. It is a long-term oral treatment used to prevent COPD exacerbations.

4. How should I take Daliresp?
   It is taken by mouth once daily, with or without food, as prescribed by your doctor.

5. Can Daliresp be taken with other COPD medications?
   Yes, it is often used in combination with bronchodilators or inhaled corticosteroids.

6. How long does it take Daliresp to start working?
   It may take several weeks to notice its full effect. It is meant for long-term use, not immediate relief.

7. Does Daliresp cure COPD?
   No, it does not cure COPD, but it helps manage the condition and reduce flare-ups.

8. Are there any major side effects of Daliresp?
   Yes, possible side effects include weight loss, diarrhea, nausea, headache, and psychiatric symptoms like anxiety or depression.

9. Is Daliresp a steroid?
   No, Daliresp is not a steroid. It is a phosphodiesterase-4 (PDE4) inhibitor.

10. Can Daliresp affect mental health?
    Yes, it can cause mood changes, including anxiety, depression, or suicidal thoughts in some individuals.

Usage & Safety FAQs

11. Who should not take Daliresp?
    People with severe liver disease or a history of depression or suicidal thoughts should consult their doctor before taking it.

12. Can Daliresp cause weight loss?
    Yes, unexplained weight loss is a known side effect, and your weight should be monitored regularly.

13. Is it safe to drink alcohol while taking Daliresp?
    Alcohol may increase the risk of side effects and should be consumed cautiously or avoided.

14. Can pregnant women take Daliresp?
    Daliresp is not recommended during pregnancy unless clearly needed. Consult your doctor.

15. What happens if I miss a dose?
    Take the missed dose as soon as you remember unless it’s close to the time for your next dose. Do not double up.

Technical & Drug Info FAQs

16. What is the generic name of Daliresp?
    The generic name is roflumilast.

17. Is Daliresp available as a generic?
    Yes, generic roflumilast is available.

18. What class of drug is Daliresp?
    It belongs to the class of Phosphodiesterase-4 (PDE4) inhibitors.

19. Is Daliresp a controlled substance?
    No, Daliresp is not a controlled substance.

20. Is Daliresp available in the U.S.?
    Yes, Daliresp is available by prescription in the United States.