Step-by-Step Instructions:

1. Take one tablet each day, around the same time.
   
   
2. Swallow with water. You can take it with or without food.
   
   
3. If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose—don’t take two at once.
   
   
4. Follow your doctor’s advice about whether to take a progestin with Femtrace.
   
   

Femtrace is meant to be taken regularly to keep hormone levels steady. Do not stop taking it unless your doctor tells you to.

During menopause, a woman’s body stops making as much estrogen, which can lead to uncomfortable symptoms and health issues. Femtrace helps by replacing the estrogen your body has lost.

Here’s how it works:

• Reduces hot flashes by helping the body control temperature
  
  
• Improves vaginal health by keeping tissues moist and healthy
  
  
• Helps mood and sleep by balancing hormones
  
  
• Supports bones and helps prevent osteoporosis
  
  

Femtrace delivers estradiol acetate, which the body converts into estradiol, a natural form of estrogen. This helps bring hormone levels closer to normal.

Like all medications, Femtrace may cause side effects. Most are mild, but some can be serious.

Common Side Effects:

• Nausea
  
  
• Breast tenderness
  
  
• Bloating
  
  
• Headache
  
  
• Spotting or irregular bleeding
  
  
• Mood changes
  
  

These usually go away after your body adjusts to the hormone.

Serious Side Effects (seek medical help):

• Blood clots (in legs or lungs)
  
  
• Stroke
  
  
• Heart attack
  
  
• Breast or uterine cancer
  
  
• Liver problems
  
  
• Vision changes
  
  
• High blood pressure
  
  

Call your doctor right away if you have:

• Chest pain or shortness of breath
  
  
• Severe headaches
  
  
• Leg pain or swelling
  
  
• Unusual vaginal bleeding
  
  
• Yellow skin or eyes
  
  

Femtrace is not for everyone. Before starting, tell your doctor about your health history.

Do NOT use Femtrace if you:

• Have or had breast cancer
  
  
• Have liver disease
  
  
• Have a history of blood clots, stroke, or heart attack
  
  
• Are pregnant or think you may be
  
  
• Have unexplained vaginal bleeding
  
  
• Have had uterine or ovarian cancer
  
  

Use with caution if you:

• Smoke (especially over age 35)
  
  
• Have diabetes, high cholesterol, or high blood pressure
  
  
• Have gallbladder disease
  
  
• Have migraines or seizures
  
  
• Have a family history of cancer
  
  

Your doctor may suggest:

• Regular pelvic exams
  
  
• Breast exams or mammograms
  
  
• Blood pressure checks
  
  

Discuss the risks and benefits of hormone therapy before starting Femtrace.

Femtrace may interact with other medications, such as:

• Seizure drugs (like phenytoin, carbamazepine)
  
  
• HIV medications
  
  
• Antibiotics (such as rifampin)
  
  
• Blood thinners (like warfarin)
  
  
• Thyroid medications
  
  

Also, herbal supplements like St. John’s Wort can affect how Femtrace works. Always tell your doctor about all medicines and supplements you are taking.

Femtrace is available in the following doses:

• 0.45 mg
  
  
• 0.625 mg
  
  
• 1.25 mg
  
  

Most doctors start patients at the lowest dose that works for them. The goal is to:

• Use the lowest dose possible
  
  
• For the shortest amount of time
  
  
• To relieve specific symptoms
  
  

Take one tablet daily, and follow up with your doctor regularly to decide:

• Whether to adjust the dose
  
  
• Whether to add a progestin
  
  
• When to stop or continue treatment
  
  

Femtrace is a prescription-only medicine. You will need a doctor to:

• Review your menopause symptoms
  
  
• Check your health history
  
  
• Possibly order blood tests, a pelvic exam, or a mammogram
  
  

Because Femtrace contains hormones, it’s important to:

• Not share it with others
  
  
• Check in regularly with your doctor
  
  
• Update your doctor if your health changes
  
  

Your doctor may prescribe a monthly, 3-month, or yearly supply, depending on your needs and insurance.

• What is Femring used for?
  It is a vaginal estrogen ring used to treat moderate to severe menopausal symptoms, including:

  • Hot flashes and night sweats (vasomotor symptoms)

  • Vaginal dryness, itching, and burning associated with menopause

• What is the active ingredient?
  Estradiol acetate, a form of estrogen hormone.

• How does Femring work?
  The ring releases a steady dose of estrogen through the vaginal wall into the bloodstream, helping restore hormonal balance and relieve menopausal symptoms.

• How is Femring used?

  • It is a soft, flexible vaginal ring inserted into the vagina by hand.

  • The ring stays in place continuously for 90 days (3 months) and is then replaced with a new one.

• What strengths are available?

  • Femring 0.05 mg/day

  • Femring 0.10 mg/day
    Both provide systemic estrogen therapy.

• Is Femring a local or systemic therapy?
  Systemic — unlike low-dose local rings (like Estring), Femring releases enough estrogen to treat whole-body symptoms such as hot flashes.

• What are the common side effects?
  Headache, breast tenderness, nausea, bloating, vaginal discharge, and mild irritation at the site of insertion.

• Are there serious side effects?
  Yes — Femring carries boxed warnings for risks associated with systemic estrogen therapy, including:

  • Stroke and blood clots

  • Heart attack

  • Breast cancer

  • Endometrial cancer (if uterus is present and no progestin is used)

  • Dementia in older women

• Who should not use Femring?

  • Women with breast or uterine cancer

  • Those with blood clots, stroke, or heart disease history

  • Liver disease or undiagnosed vaginal bleeding

  • Women who are pregnant or may become pregnant

• Can Femring be used after hysterectomy?
  Yes — women without a uterus can safely use estrogen-only therapy without progestin.

• Can I remove Femring for cleaning?
  Yes — it can be removed, rinsed with lukewarm water, and reinserted immediately.

• Can I have sex while using Femring?
  Yes — most partners do not feel it, though it can be removed temporarily if uncomfortable.

• Can Femring fall out?
  Rarely — if it does, rinse and reinsert promptly.

• Does Femring affect menstruation?
  It may cause light spotting in the first months, but regular periods do not occur in postmenopausal women.

• Can Femring prevent osteoporosis?
  It helps reduce bone loss but is not the first-line treatment for osteoporosis prevention.

• Can Femring be used during pregnancy?
  No — it is contraindicated during pregnancy.

• Can I use Femring while breastfeeding?
  Not recommended — estrogen may reduce milk production.

• Does Femring interact with other medications?
  Yes — it may interact with drugs that affect estrogen metabolism, including:

  • Rifampin

  • Carbamazepine

  • Phenytoin

  • St. John’s wort

• What’s the difference between Femring and Estring?

  • Femring: Systemic estrogen for hot flashes and vaginal symptoms.

  • Estring: Local estrogen for vaginal dryness only.

• How should Femring be stored?
  Store at room temperature (20°C–25°C / 68°F–77°F), away from direct heat and sunlight.

• Is there a generic available?
  No — Femring is currently available as brand only.

• Where can I get Femring?
  Available by prescription only from pharmacies.